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A Brief Dementia Test with Subjective and Objective Measures.

Tew CW, Ng TP, Cheong CY, Yap P - Dement Geriatr Cogn Dis Extra (2015)

Bottom Line: The development of an effective brief dementia test will help in the early identification of dementia.This study investigates the diagnostic utility of a brief cognitive test for dementia which combines a short subjective informant-rated questionnaire (AD8) with an objective cognitive measure (Mini-Mental State Examination, MMSE) or its subcomponents.Subjects with mild dementia (Clinical Dementia Rating Scale score ≤1) were matched with community-dwelling, cognitively intact controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.

ABSTRACT

Background: The development of an effective brief dementia test will help in the early identification of dementia.

Aim: This study investigates the diagnostic utility of a brief cognitive test for dementia which combines a short subjective informant-rated questionnaire (AD8) with an objective cognitive measure (Mini-Mental State Examination, MMSE) or its subcomponents.

Methods: Subjects with mild dementia (Clinical Dementia Rating Scale score ≤1) were matched with community-dwelling, cognitively intact controls. MMSE and Clinical Dementia Rating Scale were administered to all subjects, while AD8 was completed by a reliable informant. Receiver operating characteristics analysis determined the diagnostic accuracies of AD8, MMSE, and AD8 combined with MMSE (AD8+MMSE). Stepwise logistic regression identified the subcomponents of MMSE which, combined with AD8, best discriminated dementia patients from controls.

Results: The AD8 (area under the curve [AUC] = 0.92, 95% confidence interval [CI] 0.89-0.95) was superior to the MMSE (AUC = 0.87, 95% CI 0.83-0.92) in discriminating mild dementia patients from controls, and AD8+MMSE (AUC = 0.95, 0.92-0.98) increased its superior discrimination over MMSE alone. AD8 combined with three-item recall and intersecting pentagon copy (AUC = 0.95, 95% CI 0.92-0.97) performed as well as AD8 combined with full MMSE.

Conclusion: AD8 combined with the MMSE subcomponents three-item recall and intersecting pentagon copy has excellent diagnostic utility and is a promising brief cognitive test for early dementia.

No MeSH data available.


Related in: MedlinePlus

ROC comparing the utility of AD8, MMSE, AD8+MMSE, AD8+Recall and AD8+Recall+Copy in discriminating mild dementia from no dementia.
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Figure 1: ROC comparing the utility of AD8, MMSE, AD8+MMSE, AD8+Recall and AD8+Recall+Copy in discriminating mild dementia from no dementia.

Mentions: ROC were generated for AD8 alone, MMSE alone, AD8+MMSE, AD8+Recall and AD8+Recall+Copy (fig. 1). The area under the curve (AUC) for each model is reported in table 3. AD8 showed excellent diagnostic performance in differentiating mild dementia from no dementia with an AUC of 0.92 (95% CI 0.89-0.95) and was superior to MMSE (AUC = 0.87, 95% CI 0.83-0.92). The combined AD8+MMSE, with an AUC of 0.95 (95% CI 0.92-0.98) increased its superior discrimination over MMSE alone. The briefer versions of AD8+Recall (AUC = 0.94, 95% CI 0.91-0.97) and AD8+Recall+Copy (AUC = 0.95, 95% CI 0.92-0.97) performed comparably with the combination of AD8 and full MMSE.


A Brief Dementia Test with Subjective and Objective Measures.

Tew CW, Ng TP, Cheong CY, Yap P - Dement Geriatr Cogn Dis Extra (2015)

ROC comparing the utility of AD8, MMSE, AD8+MMSE, AD8+Recall and AD8+Recall+Copy in discriminating mild dementia from no dementia.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608606&req=5

Figure 1: ROC comparing the utility of AD8, MMSE, AD8+MMSE, AD8+Recall and AD8+Recall+Copy in discriminating mild dementia from no dementia.
Mentions: ROC were generated for AD8 alone, MMSE alone, AD8+MMSE, AD8+Recall and AD8+Recall+Copy (fig. 1). The area under the curve (AUC) for each model is reported in table 3. AD8 showed excellent diagnostic performance in differentiating mild dementia from no dementia with an AUC of 0.92 (95% CI 0.89-0.95) and was superior to MMSE (AUC = 0.87, 95% CI 0.83-0.92). The combined AD8+MMSE, with an AUC of 0.95 (95% CI 0.92-0.98) increased its superior discrimination over MMSE alone. The briefer versions of AD8+Recall (AUC = 0.94, 95% CI 0.91-0.97) and AD8+Recall+Copy (AUC = 0.95, 95% CI 0.92-0.97) performed comparably with the combination of AD8 and full MMSE.

Bottom Line: The development of an effective brief dementia test will help in the early identification of dementia.This study investigates the diagnostic utility of a brief cognitive test for dementia which combines a short subjective informant-rated questionnaire (AD8) with an objective cognitive measure (Mini-Mental State Examination, MMSE) or its subcomponents.Subjects with mild dementia (Clinical Dementia Rating Scale score ≤1) were matched with community-dwelling, cognitively intact controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore, Singapore.

ABSTRACT

Background: The development of an effective brief dementia test will help in the early identification of dementia.

Aim: This study investigates the diagnostic utility of a brief cognitive test for dementia which combines a short subjective informant-rated questionnaire (AD8) with an objective cognitive measure (Mini-Mental State Examination, MMSE) or its subcomponents.

Methods: Subjects with mild dementia (Clinical Dementia Rating Scale score ≤1) were matched with community-dwelling, cognitively intact controls. MMSE and Clinical Dementia Rating Scale were administered to all subjects, while AD8 was completed by a reliable informant. Receiver operating characteristics analysis determined the diagnostic accuracies of AD8, MMSE, and AD8 combined with MMSE (AD8+MMSE). Stepwise logistic regression identified the subcomponents of MMSE which, combined with AD8, best discriminated dementia patients from controls.

Results: The AD8 (area under the curve [AUC] = 0.92, 95% confidence interval [CI] 0.89-0.95) was superior to the MMSE (AUC = 0.87, 95% CI 0.83-0.92) in discriminating mild dementia patients from controls, and AD8+MMSE (AUC = 0.95, 0.92-0.98) increased its superior discrimination over MMSE alone. AD8 combined with three-item recall and intersecting pentagon copy (AUC = 0.95, 95% CI 0.92-0.97) performed as well as AD8 combined with full MMSE.

Conclusion: AD8 combined with the MMSE subcomponents three-item recall and intersecting pentagon copy has excellent diagnostic utility and is a promising brief cognitive test for early dementia.

No MeSH data available.


Related in: MedlinePlus