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Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.

Lu J, Zhao Q, Zhai YJ, He HR, Yang LH, Gao F, Zhou RS, Zheng J, Ma XC - Onco Targets Ther (2015)

Bottom Line: Finally, T3801C was associated with an increased risk of AML in Asians under the dominant model.In conclusion, the results suggest that Asians carrying the T3801C C allele might have an increased risk of AML and that Caucasians with the A2455G GG genotype might have an increased risk of ALL.Further investigations are needed to confirm these associations.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Center, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

ABSTRACT
The associations between CYP1A1 polymorphisms and risk of leukemia have been studied extensively, but the results have been inconsistent. Therefore, in this study, we performed a meta-analysis to clarify associations of three CYP1A1 polymorphisms (T3801C, A2455G, and C4887A) with the risks of acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). Medline, EMBASE, and China National Knowledge Infrastructure databases were searched to collect relevant studies published up to April 20, 2015. The extracted data were analyzed statistically, and pooled odds ratios with 95% confidence intervals were calculated to quantify the associations. Overall, 26 publications were included. Finally, T3801C was associated with an increased risk of AML in Asians under the dominant model. For A2455G, the risk of ALL was increased among Caucasians in the recessive model and the allele-contrast model; A2455G was also associated with an increased risk of CML among Caucasians under the recessive model, dominant model, and allele-contrast model. For C4887A, few of the included studies produced data. In conclusion, the results suggest that Asians carrying the T3801C C allele might have an increased risk of AML and that Caucasians with the A2455G GG genotype might have an increased risk of ALL. Further investigations are needed to confirm these associations.

No MeSH data available.


Related in: MedlinePlus

Meta-analysis of the association between CYP1A1 A2455G gene polymorphism and ALL risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.Abbreviations: CML, chronic myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; ALL, acute lymphoblastic leukemia.
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f3-ott-8-2883: Meta-analysis of the association between CYP1A1 A2455G gene polymorphism and ALL risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.Abbreviations: CML, chronic myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; ALL, acute lymphoblastic leukemia.

Mentions: In subgroup analysis according to race, the risk of leukemia was higher in Caucasians under the recessive model (P=0.002, OR =2.23, 95% CI =1.36–3.68) and the allele-contrast model (P=0.010, OR =1.31, 95% CI =1.07–1.61), but not under the dominant model (P=0.12, OR =1.22, 95% CI =0.95–1.58) (Figure 3).


Genetic polymorphisms of CYP1A1 and risk of leukemia: a meta-analysis.

Lu J, Zhao Q, Zhai YJ, He HR, Yang LH, Gao F, Zhou RS, Zheng J, Ma XC - Onco Targets Ther (2015)

Meta-analysis of the association between CYP1A1 A2455G gene polymorphism and ALL risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.Abbreviations: CML, chronic myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; ALL, acute lymphoblastic leukemia.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608596&req=5

f3-ott-8-2883: Meta-analysis of the association between CYP1A1 A2455G gene polymorphism and ALL risk under three models: (A) recessive, (B) dominant, and (C) allele contrast.Abbreviations: CML, chronic myeloid leukemia; CI, confidence interval; M–H, Mantel–Haenszel type; OR, odds ratio; ALL, acute lymphoblastic leukemia.
Mentions: In subgroup analysis according to race, the risk of leukemia was higher in Caucasians under the recessive model (P=0.002, OR =2.23, 95% CI =1.36–3.68) and the allele-contrast model (P=0.010, OR =1.31, 95% CI =1.07–1.61), but not under the dominant model (P=0.12, OR =1.22, 95% CI =0.95–1.58) (Figure 3).

Bottom Line: Finally, T3801C was associated with an increased risk of AML in Asians under the dominant model.In conclusion, the results suggest that Asians carrying the T3801C C allele might have an increased risk of AML and that Caucasians with the A2455G GG genotype might have an increased risk of ALL.Further investigations are needed to confirm these associations.

View Article: PubMed Central - PubMed

Affiliation: Clinical Research Center, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

ABSTRACT
The associations between CYP1A1 polymorphisms and risk of leukemia have been studied extensively, but the results have been inconsistent. Therefore, in this study, we performed a meta-analysis to clarify associations of three CYP1A1 polymorphisms (T3801C, A2455G, and C4887A) with the risks of acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML). Medline, EMBASE, and China National Knowledge Infrastructure databases were searched to collect relevant studies published up to April 20, 2015. The extracted data were analyzed statistically, and pooled odds ratios with 95% confidence intervals were calculated to quantify the associations. Overall, 26 publications were included. Finally, T3801C was associated with an increased risk of AML in Asians under the dominant model. For A2455G, the risk of ALL was increased among Caucasians in the recessive model and the allele-contrast model; A2455G was also associated with an increased risk of CML among Caucasians under the recessive model, dominant model, and allele-contrast model. For C4887A, few of the included studies produced data. In conclusion, the results suggest that Asians carrying the T3801C C allele might have an increased risk of AML and that Caucasians with the A2455G GG genotype might have an increased risk of ALL. Further investigations are needed to confirm these associations.

No MeSH data available.


Related in: MedlinePlus