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Fear of pain potentiates nocebo hyperalgesia.

Aslaksen PM, Lyby PS - J Pain Res (2015)

Bottom Line: The results revealed that pain and stress levels were significantly higher in the Nocebo group after nocebo treatment.There were no significant associations between any of the personality factors and the nocebo hyperalgesic effect.Furthermore, measurement of traits that are specific to pain experience is probably better suited for prediction of nocebo hyperalgesic responses compared to broad measures of personality.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Research Group for Cognitive Neuroscience, The Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

ABSTRACT
Nocebo hyperalgesia has received sparse experimental attention compared to placebo analgesia. The aim of the present study was to investigate if personality traits and fear of pain could predict experimental nocebo hyperalgesia. One hundred and eleven healthy volunteers (76 females) participated in an experimental study in which personality traits and fear of pain were measured prior to induction of thermal heat pain. Personality traits were measured by the Big-Five Inventory-10. Fear of pain was measured by the Fear of Pain Questionnaire III. Heat pain was induced by a PC-controlled thermode. Pain was measured by a computerized visual analog scale. Stress levels during the experiment were measured by numerical rating scales. The participants were randomized to a Nocebo group or to a no-treatment Natural History group. The results revealed that pain and stress levels were significantly higher in the Nocebo group after nocebo treatment. Mediation analysis showed that higher levels of the Fear of Pain Questionnaire III factor "fear of medical pain" significantly increased stress levels after nocebo treatment and that higher stress levels were associated with increased nocebo hyperalgesic responses. There were no significant associations between any of the personality factors and the nocebo hyperalgesic effect. The results from the present study suggest that dispositional fear of pain might be a useful predictor for nocebo hyperalgesia and emotional states concomitant with expectations of increased pain. Furthermore, measurement of traits that are specific to pain experience is probably better suited for prediction of nocebo hyperalgesic responses compared to broad measures of personality.

No MeSH data available.


Related in: MedlinePlus

Overview of the experimental procedure.
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f1-jpr-8-703: Overview of the experimental procedure.

Mentions: Following a 20-minute application period, subjective stress was measured. Subsequently, the thermode was again attached to the forearm 1 cm below the site of the thermode stimulation in the pretest to avoid possible lesion-related hyperalgesia, and the experimenter initiated the last two pain stimulations (posttests). The interval between the posttests was 2 minutes. After the last posttest, the final subjective stress measurement was obtained. The experimental procedure had a total duration of ~45 minutes. Figure 1 shows an overview of the procedure.


Fear of pain potentiates nocebo hyperalgesia.

Aslaksen PM, Lyby PS - J Pain Res (2015)

Overview of the experimental procedure.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608595&req=5

f1-jpr-8-703: Overview of the experimental procedure.
Mentions: Following a 20-minute application period, subjective stress was measured. Subsequently, the thermode was again attached to the forearm 1 cm below the site of the thermode stimulation in the pretest to avoid possible lesion-related hyperalgesia, and the experimenter initiated the last two pain stimulations (posttests). The interval between the posttests was 2 minutes. After the last posttest, the final subjective stress measurement was obtained. The experimental procedure had a total duration of ~45 minutes. Figure 1 shows an overview of the procedure.

Bottom Line: The results revealed that pain and stress levels were significantly higher in the Nocebo group after nocebo treatment.There were no significant associations between any of the personality factors and the nocebo hyperalgesic effect.Furthermore, measurement of traits that are specific to pain experience is probably better suited for prediction of nocebo hyperalgesic responses compared to broad measures of personality.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychology, Research Group for Cognitive Neuroscience, The Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.

ABSTRACT
Nocebo hyperalgesia has received sparse experimental attention compared to placebo analgesia. The aim of the present study was to investigate if personality traits and fear of pain could predict experimental nocebo hyperalgesia. One hundred and eleven healthy volunteers (76 females) participated in an experimental study in which personality traits and fear of pain were measured prior to induction of thermal heat pain. Personality traits were measured by the Big-Five Inventory-10. Fear of pain was measured by the Fear of Pain Questionnaire III. Heat pain was induced by a PC-controlled thermode. Pain was measured by a computerized visual analog scale. Stress levels during the experiment were measured by numerical rating scales. The participants were randomized to a Nocebo group or to a no-treatment Natural History group. The results revealed that pain and stress levels were significantly higher in the Nocebo group after nocebo treatment. Mediation analysis showed that higher levels of the Fear of Pain Questionnaire III factor "fear of medical pain" significantly increased stress levels after nocebo treatment and that higher stress levels were associated with increased nocebo hyperalgesic responses. There were no significant associations between any of the personality factors and the nocebo hyperalgesic effect. The results from the present study suggest that dispositional fear of pain might be a useful predictor for nocebo hyperalgesia and emotional states concomitant with expectations of increased pain. Furthermore, measurement of traits that are specific to pain experience is probably better suited for prediction of nocebo hyperalgesic responses compared to broad measures of personality.

No MeSH data available.


Related in: MedlinePlus