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The association of GSTT1 deletion polymorphism with lung cancer risk among Chinese population: evidence based on a cumulative meta-analysis.

Wang Y, Yang H, Wang H - Onco Targets Ther (2015)

Bottom Line: To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched.The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

View Article: PubMed Central - PubMed

Affiliation: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, People's Republic of China.

ABSTRACT

Objective: Previous studies investigating the relationship between glutathione S-transferase T1 (GSTT1) gene deletion polymorphism and lung cancer risk among Chinese population produced inconsistent results. To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.

Methods: The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched. The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

Results: Overall, we found an increased lung cancer risk among subjects carrying GSTT1 genotype compared with those carrying present genotype (OR =1.31, 95% CI: 1.12-1.52) on the basis of 20 studies with 3,351 cases and 4,683 controls. We also observed an increased risk of lung cancer among subjects carrying GSTT1 genotype compared with those carrying present genotype in stratified analyses (OR =1.31, 95% CI: 1.11-1.55 for healthy subjects-based control; OR =2.29, 95% CI: 1.84-2.85 for squamous cell carcinoma and OR =1.47, 95% CI: 1.22-1.77 for adenocarcinoma, respectively).

Conclusion: This meta-analysis suggested that GSTT1 deletion polymorphism might contribute to lung cancer risk among Chinese population.

No MeSH data available.


Related in: MedlinePlus

Funnel plot analysis to detect publication bias for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations: GSTT1, glutathione S-transferase T1; OR, odds ratio; SE, standard error of mean.
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f3-ott-8-2875: Funnel plot analysis to detect publication bias for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations: GSTT1, glutathione S-transferase T1; OR, odds ratio; SE, standard error of mean.

Mentions: Publication bias was examined by using funnel plot analysis. The shape of the funnel plot seemed to be approximately symmetrical (Figure 3). Both Egger’s test and Begg’s test suggested that publication bias might have few effects on the summary estimates, except for the subgroup analysis of squamous cell carcinoma, owing to P-value being equal to 0.024 in Begg’s test.


The association of GSTT1 deletion polymorphism with lung cancer risk among Chinese population: evidence based on a cumulative meta-analysis.

Wang Y, Yang H, Wang H - Onco Targets Ther (2015)

Funnel plot analysis to detect publication bias for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations: GSTT1, glutathione S-transferase T1; OR, odds ratio; SE, standard error of mean.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608590&req=5

f3-ott-8-2875: Funnel plot analysis to detect publication bias for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations: GSTT1, glutathione S-transferase T1; OR, odds ratio; SE, standard error of mean.
Mentions: Publication bias was examined by using funnel plot analysis. The shape of the funnel plot seemed to be approximately symmetrical (Figure 3). Both Egger’s test and Begg’s test suggested that publication bias might have few effects on the summary estimates, except for the subgroup analysis of squamous cell carcinoma, owing to P-value being equal to 0.024 in Begg’s test.

Bottom Line: To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched.The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

View Article: PubMed Central - PubMed

Affiliation: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, People's Republic of China.

ABSTRACT

Objective: Previous studies investigating the relationship between glutathione S-transferase T1 (GSTT1) gene deletion polymorphism and lung cancer risk among Chinese population produced inconsistent results. To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.

Methods: The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched. The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

Results: Overall, we found an increased lung cancer risk among subjects carrying GSTT1 genotype compared with those carrying present genotype (OR =1.31, 95% CI: 1.12-1.52) on the basis of 20 studies with 3,351 cases and 4,683 controls. We also observed an increased risk of lung cancer among subjects carrying GSTT1 genotype compared with those carrying present genotype in stratified analyses (OR =1.31, 95% CI: 1.11-1.55 for healthy subjects-based control; OR =2.29, 95% CI: 1.84-2.85 for squamous cell carcinoma and OR =1.47, 95% CI: 1.22-1.77 for adenocarcinoma, respectively).

Conclusion: This meta-analysis suggested that GSTT1 deletion polymorphism might contribute to lung cancer risk among Chinese population.

No MeSH data available.


Related in: MedlinePlus