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The association of GSTT1 deletion polymorphism with lung cancer risk among Chinese population: evidence based on a cumulative meta-analysis.

Wang Y, Yang H, Wang H - Onco Targets Ther (2015)

Bottom Line: To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched.The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

View Article: PubMed Central - PubMed

Affiliation: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, People's Republic of China.

ABSTRACT

Objective: Previous studies investigating the relationship between glutathione S-transferase T1 (GSTT1) gene deletion polymorphism and lung cancer risk among Chinese population produced inconsistent results. To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.

Methods: The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched. The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

Results: Overall, we found an increased lung cancer risk among subjects carrying GSTT1 genotype compared with those carrying present genotype (OR =1.31, 95% CI: 1.12-1.52) on the basis of 20 studies with 3,351 cases and 4,683 controls. We also observed an increased risk of lung cancer among subjects carrying GSTT1 genotype compared with those carrying present genotype in stratified analyses (OR =1.31, 95% CI: 1.11-1.55 for healthy subjects-based control; OR =2.29, 95% CI: 1.84-2.85 for squamous cell carcinoma and OR =1.47, 95% CI: 1.22-1.77 for adenocarcinoma, respectively).

Conclusion: This meta-analysis suggested that GSTT1 deletion polymorphism might contribute to lung cancer risk among Chinese population.

No MeSH data available.


Related in: MedlinePlus

Forest plot of OR for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations:GSTT1, glutathione S-transferase T1; OR, odds ratio; CI, confidence interval; M–H, Mantel–Haenszel test.
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f1-ott-8-2875: Forest plot of OR for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations:GSTT1, glutathione S-transferase T1; OR, odds ratio; CI, confidence interval; M–H, Mantel–Haenszel test.

Mentions: Table 2 listed the summary ORs of the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population on the basis of 3,351 cases and 4,683 controls. Overall, there was a statistically significant correlation of GSTT1 genotype with an increased lung cancer risk among Chinese population, and the summary OR was 1.31 (95% CI: 1.12–1.52; Figure 1). The cumulative meta-analysis accumulated the studies according to the year of publications, which may determine whether new studies are needed or not. Our results showed that there was still a significant association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population; the cumulative OR was 1.31 with 95% CI: 1.12–1.52 (Figure 2).


The association of GSTT1 deletion polymorphism with lung cancer risk among Chinese population: evidence based on a cumulative meta-analysis.

Wang Y, Yang H, Wang H - Onco Targets Ther (2015)

Forest plot of OR for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations:GSTT1, glutathione S-transferase T1; OR, odds ratio; CI, confidence interval; M–H, Mantel–Haenszel test.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608590&req=5

f1-ott-8-2875: Forest plot of OR for GSTT1 deletion polymorphism associated with lung cancer risk among Chinese population.Abbreviations:GSTT1, glutathione S-transferase T1; OR, odds ratio; CI, confidence interval; M–H, Mantel–Haenszel test.
Mentions: Table 2 listed the summary ORs of the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population on the basis of 3,351 cases and 4,683 controls. Overall, there was a statistically significant correlation of GSTT1 genotype with an increased lung cancer risk among Chinese population, and the summary OR was 1.31 (95% CI: 1.12–1.52; Figure 1). The cumulative meta-analysis accumulated the studies according to the year of publications, which may determine whether new studies are needed or not. Our results showed that there was still a significant association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population; the cumulative OR was 1.31 with 95% CI: 1.12–1.52 (Figure 2).

Bottom Line: To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched.The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

View Article: PubMed Central - PubMed

Affiliation: Department of Toxicology, Henan Center for Disease Control and Prevention, Zhengzhou, People's Republic of China.

ABSTRACT

Objective: Previous studies investigating the relationship between glutathione S-transferase T1 (GSTT1) gene deletion polymorphism and lung cancer risk among Chinese population produced inconsistent results. To obtain a precise conclusion, we performed this meta-analysis to evaluate the association between GSTT1 deletion polymorphism and lung cancer risk among Chinese population.

Methods: The databases of Medline/PubMed, Embase, Web of Science, Wanfang Med Online, and Chinese National Knowledge Infrastructure were searched. The strength of the association was assessed by odds ratio (OR) with 95% confidence intervals (95% CI).

Results: Overall, we found an increased lung cancer risk among subjects carrying GSTT1 genotype compared with those carrying present genotype (OR =1.31, 95% CI: 1.12-1.52) on the basis of 20 studies with 3,351 cases and 4,683 controls. We also observed an increased risk of lung cancer among subjects carrying GSTT1 genotype compared with those carrying present genotype in stratified analyses (OR =1.31, 95% CI: 1.11-1.55 for healthy subjects-based control; OR =2.29, 95% CI: 1.84-2.85 for squamous cell carcinoma and OR =1.47, 95% CI: 1.22-1.77 for adenocarcinoma, respectively).

Conclusion: This meta-analysis suggested that GSTT1 deletion polymorphism might contribute to lung cancer risk among Chinese population.

No MeSH data available.


Related in: MedlinePlus