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Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study.

Lin H, Li Q, Liu X, Ma H, Xia M, Wang D, Li X, Wu J, Zhao N, Pan B, Gao X - PLoS ONE (2015)

Bottom Line: A total of 4,305 people aged 45 years and above without excessive drinking were enrolled.The LFC was positively correlated with SUA (r = 0.130, P < 0.001) and an independent factor for SUA (standardized β = 0.054, P < 0.001).The OR for the presence of hypreuricemia was 1.175 (95% CI 1.048-1.318; P < 0.001) with a 1 SD increase in the log LFC.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China; Research center on aging and medicine, Fudan University, Shanghai, China.

ABSTRACT

Background and aims: Although many studies have indicated a relationship between nonalcoholic fatty liver disease (NAFLD) and hyperuricemia, a few studies specifically examining the effects of the severity of liver fat content (LFC) on serum uric acid (SUA) and the presence of hyperuricemia because of the limitation of the examination methods for NAFLD. In this study, we investigate the relationship between the NAFLD and SUA levels in the Chinese population using standardized quantitative ultrasound.

Methods: A community-based study was conducted from May 2010 to December 2012. A total of 4,305 people aged 45 years and above without excessive drinking were enrolled. A standard interview and anthropometric and laboratory blood parameters were collected for each person. The standardized ultrasound hepatic/renal ratio and hepatic attenuation rate was used to quantify LFC.

Results: The prevalence of NAFLD and hyperuricemia was 33.1% and 17.1%, respectively. A total of 23.5% of the NAFLD subjects had hyperuricemia, and their SUA was higher than that of non-NAFLD subjects (327.2 ± 76.8 vs 301.9 ± 77.4 μmol/L, P < 0.001). The LFC was positively correlated with SUA (r = 0.130, P < 0.001) and an independent factor for SUA (standardized β = 0.054, P < 0.001). The OR for the presence of hypreuricemia was 1.175 (95% CI 1.048-1.318; P < 0.001) with a 1 SD increase in the log LFC. LFC greater than 10% was related to elevated SUA and an increased presence of hyperuricemia.

Conclusions: LFC accumulation was associated with an increase in the prevalence of hyperuricemia and elevated SUA in our community-based population. LFC greater than 10% is related to the risk for hyperuricemia.

No MeSH data available.


Related in: MedlinePlus

Prevalence of hyperuricemia with increases in the LFC.In total, the prevalence of hyperuricemia was 13.7%, 14.3%, 24.2%, 24.9% and 23.6%, respectively with each additional 5% of stratified LFC from <5% to > = 20%. In male, the prevalence was 17.4%, 16.8%, 24.5%, 26.1% and 23.0%, respectively; in female, the prevalence was 11.7%, 13.2%, 24.1%, 24.4% and 24.0%, respectively. ※: compared with LFC<5%, P<0.05
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pone.0140379.g001: Prevalence of hyperuricemia with increases in the LFC.In total, the prevalence of hyperuricemia was 13.7%, 14.3%, 24.2%, 24.9% and 23.6%, respectively with each additional 5% of stratified LFC from <5% to > = 20%. In male, the prevalence was 17.4%, 16.8%, 24.5%, 26.1% and 23.0%, respectively; in female, the prevalence was 11.7%, 13.2%, 24.1%, 24.4% and 24.0%, respectively. ※: compared with LFC<5%, P<0.05

Mentions: The prevalence of hyperuricemia increased with each additional 5% of stratified LFC (Fig 1). There was no significant difference between LFC <5% and LFC 5~10%, but the prevalence of hyperuricemia significantly increased when the LFC was greater than 10% compared with LFC<5%, and there was no difference in this correlation for either males of females. Compared with the LFC<5% group, the OR (95% CI) for the presence of hyperuricemia associated with the LFC 10~15%, 15~20% and greater than 20% groups was 1.138 (1.085–1.194), 1.148 (1.083–1.218) and 1.130 (1.055–1.209), respectively, for the total population, and 1.163 (1.099–1.231), 1.168 (1.091–1.251) and 1.162 (1.067–1.266), respectively, for females alone (Table 5). Multiple logistic regression analysis demonstrated that LFC was an independent factor for hyperuricemia in the total and female population. For a 1 SD increase in the Log LFC, the risk for the occurrence of hyperuricemia was 1.175 (95% CI 1.048–1.318) for the total population and 1.210 (95% CI 1.027–1.426) for females alone. (Fig 2).


Liver Fat Content Is Associated with Elevated Serum Uric Acid in the Chinese Middle-Aged and Elderly Populations: Shanghai Changfeng Study.

Lin H, Li Q, Liu X, Ma H, Xia M, Wang D, Li X, Wu J, Zhao N, Pan B, Gao X - PLoS ONE (2015)

Prevalence of hyperuricemia with increases in the LFC.In total, the prevalence of hyperuricemia was 13.7%, 14.3%, 24.2%, 24.9% and 23.6%, respectively with each additional 5% of stratified LFC from <5% to > = 20%. In male, the prevalence was 17.4%, 16.8%, 24.5%, 26.1% and 23.0%, respectively; in female, the prevalence was 11.7%, 13.2%, 24.1%, 24.4% and 24.0%, respectively. ※: compared with LFC<5%, P<0.05
© Copyright Policy
Related In: Results  -  Collection

License
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getmorefigures.php?uid=PMC4608581&req=5

pone.0140379.g001: Prevalence of hyperuricemia with increases in the LFC.In total, the prevalence of hyperuricemia was 13.7%, 14.3%, 24.2%, 24.9% and 23.6%, respectively with each additional 5% of stratified LFC from <5% to > = 20%. In male, the prevalence was 17.4%, 16.8%, 24.5%, 26.1% and 23.0%, respectively; in female, the prevalence was 11.7%, 13.2%, 24.1%, 24.4% and 24.0%, respectively. ※: compared with LFC<5%, P<0.05
Mentions: The prevalence of hyperuricemia increased with each additional 5% of stratified LFC (Fig 1). There was no significant difference between LFC <5% and LFC 5~10%, but the prevalence of hyperuricemia significantly increased when the LFC was greater than 10% compared with LFC<5%, and there was no difference in this correlation for either males of females. Compared with the LFC<5% group, the OR (95% CI) for the presence of hyperuricemia associated with the LFC 10~15%, 15~20% and greater than 20% groups was 1.138 (1.085–1.194), 1.148 (1.083–1.218) and 1.130 (1.055–1.209), respectively, for the total population, and 1.163 (1.099–1.231), 1.168 (1.091–1.251) and 1.162 (1.067–1.266), respectively, for females alone (Table 5). Multiple logistic regression analysis demonstrated that LFC was an independent factor for hyperuricemia in the total and female population. For a 1 SD increase in the Log LFC, the risk for the occurrence of hyperuricemia was 1.175 (95% CI 1.048–1.318) for the total population and 1.210 (95% CI 1.027–1.426) for females alone. (Fig 2).

Bottom Line: A total of 4,305 people aged 45 years and above without excessive drinking were enrolled.The LFC was positively correlated with SUA (r = 0.130, P < 0.001) and an independent factor for SUA (standardized β = 0.054, P < 0.001).The OR for the presence of hypreuricemia was 1.175 (95% CI 1.048-1.318; P < 0.001) with a 1 SD increase in the log LFC.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China; Research center on aging and medicine, Fudan University, Shanghai, China.

ABSTRACT

Background and aims: Although many studies have indicated a relationship between nonalcoholic fatty liver disease (NAFLD) and hyperuricemia, a few studies specifically examining the effects of the severity of liver fat content (LFC) on serum uric acid (SUA) and the presence of hyperuricemia because of the limitation of the examination methods for NAFLD. In this study, we investigate the relationship between the NAFLD and SUA levels in the Chinese population using standardized quantitative ultrasound.

Methods: A community-based study was conducted from May 2010 to December 2012. A total of 4,305 people aged 45 years and above without excessive drinking were enrolled. A standard interview and anthropometric and laboratory blood parameters were collected for each person. The standardized ultrasound hepatic/renal ratio and hepatic attenuation rate was used to quantify LFC.

Results: The prevalence of NAFLD and hyperuricemia was 33.1% and 17.1%, respectively. A total of 23.5% of the NAFLD subjects had hyperuricemia, and their SUA was higher than that of non-NAFLD subjects (327.2 ± 76.8 vs 301.9 ± 77.4 μmol/L, P < 0.001). The LFC was positively correlated with SUA (r = 0.130, P < 0.001) and an independent factor for SUA (standardized β = 0.054, P < 0.001). The OR for the presence of hypreuricemia was 1.175 (95% CI 1.048-1.318; P < 0.001) with a 1 SD increase in the log LFC. LFC greater than 10% was related to elevated SUA and an increased presence of hyperuricemia.

Conclusions: LFC accumulation was associated with an increase in the prevalence of hyperuricemia and elevated SUA in our community-based population. LFC greater than 10% is related to the risk for hyperuricemia.

No MeSH data available.


Related in: MedlinePlus