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Body Fat Patterning, Hepatic Fat and Pancreatic Volume of Non-Obese Asian Indians with Type 2 Diabetes in North India: A Case-Control Study.

Misra A, Anoop S, Gulati S, Mani K, Bhatt SP, Pandey RM - PLoS ONE (2015)

Bottom Line: BMI, waist & hip circumferences, skinfold thickness at 8 sites, body fat, lean mass and detailed abdominal fat evaluation [total abdominal fat, total subcutaneous fat (superficial, deep, anterior, and posterior), total intra-abdominal fat (intra-peritoneal, retroperitoneal)], liver span, grades of fatty liver and pancreatic volume were compared.Specifically, the following volumes were higher in cases as compared to controls; total abdominal fat (19.4%), total intra-abdominal fat (49.7%), intra-peritoneal fat (47.7%), retroperitoneal fat (70.7%), pancreatic volume (26.6%), pancreatic volume index (21.3%) and liver span (10.8%).Importantly, increased pancreatic volume in patients was highly correlated with multiple measures of abdominal obesity and liver fat.

View Article: PubMed Central - PubMed

Affiliation: Centre of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi, India; Fortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, Nehru place, New Delhi, India; Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India.

ABSTRACT

Objective: To evaluate body fat patterning and phenotype including hepatic fat and pancreatic volume of non-obese (BMI: < 25 kg/m2) Asian Indians with type 2 diabetes residing in North India.

Methods: Non-obese patients with type 2 diabetes (n = 93) and non-obese, normo-glycemic subjects (n = 40) were recruited. BMI, waist & hip circumferences, skinfold thickness at 8 sites, body fat, lean mass and detailed abdominal fat evaluation [total abdominal fat, total subcutaneous fat (superficial, deep, anterior, and posterior), total intra-abdominal fat (intra-peritoneal, retroperitoneal)], liver span, grades of fatty liver and pancreatic volume were compared.

Results: Waist circumference, subscapular skinfolds and total truncal fat (on DEXA) were higher whereas calf, total peripheral skinfolds and total leg fat (on DEXA) lower in patients. Specifically, the following volumes were higher in cases as compared to controls; total abdominal fat (19.4%), total intra-abdominal fat (49.7%), intra-peritoneal fat (47.7%), retroperitoneal fat (70.7%), pancreatic volume (26.6%), pancreatic volume index (21.3%) and liver span (10.8%). In cases, significant positive correlations were observed for pancreatic volume with BMI, waist and hip circumferences, W-HR, subscapular, abdominal and total truncal skinfolds, truncal, total subcutaneous, total intra-abdominal, intra-peritoneal, retroperitoneal fat depots, liver span and fatty liver.

Conclusions: In non-obese Asian Indians with type 2 diabetes, subcutaneous and intra-abdominal obesity, including fatty liver, and pancreatic volume were higher and peripheral subcutaneous adiposity was lower than BMI matched non-diabetic subjects. Importantly, increased pancreatic volume in patients was highly correlated with multiple measures of abdominal obesity and liver fat.

No MeSH data available.


Related in: MedlinePlus

Abdominal fat depots, pancreatic volume & liver span measured by MRI (1.5 Tesla) in cases (n = 93, shown in black bars) & controls (n = 40, shown in box filled with crossed lines).
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pone.0140447.g002: Abdominal fat depots, pancreatic volume & liver span measured by MRI (1.5 Tesla) in cases (n = 93, shown in black bars) & controls (n = 40, shown in box filled with crossed lines).

Mentions: Volumes of abdominal fat measures were significantly higher in cases as compared to controls; total abdominal fat (19.4%; p < 0.05), total intra-abdominal fat (49.7%; p< 0.001), intra-peritoneal fat (47.7%; p< 0.001) and retroperitoneal fat (70.7%; p<0.001). Further, in cases, significantly higher mean values were observed for pancreatic volume (26.6%; p < 0.001), pancreatic volume index (21.3%; p< 0.01) & liver span (10.8%; p < 0.001), as compared to controls, even after adjustment for age (Figs 2 and 3, S4 Table).


Body Fat Patterning, Hepatic Fat and Pancreatic Volume of Non-Obese Asian Indians with Type 2 Diabetes in North India: A Case-Control Study.

Misra A, Anoop S, Gulati S, Mani K, Bhatt SP, Pandey RM - PLoS ONE (2015)

Abdominal fat depots, pancreatic volume & liver span measured by MRI (1.5 Tesla) in cases (n = 93, shown in black bars) & controls (n = 40, shown in box filled with crossed lines).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608569&req=5

pone.0140447.g002: Abdominal fat depots, pancreatic volume & liver span measured by MRI (1.5 Tesla) in cases (n = 93, shown in black bars) & controls (n = 40, shown in box filled with crossed lines).
Mentions: Volumes of abdominal fat measures were significantly higher in cases as compared to controls; total abdominal fat (19.4%; p < 0.05), total intra-abdominal fat (49.7%; p< 0.001), intra-peritoneal fat (47.7%; p< 0.001) and retroperitoneal fat (70.7%; p<0.001). Further, in cases, significantly higher mean values were observed for pancreatic volume (26.6%; p < 0.001), pancreatic volume index (21.3%; p< 0.01) & liver span (10.8%; p < 0.001), as compared to controls, even after adjustment for age (Figs 2 and 3, S4 Table).

Bottom Line: BMI, waist & hip circumferences, skinfold thickness at 8 sites, body fat, lean mass and detailed abdominal fat evaluation [total abdominal fat, total subcutaneous fat (superficial, deep, anterior, and posterior), total intra-abdominal fat (intra-peritoneal, retroperitoneal)], liver span, grades of fatty liver and pancreatic volume were compared.Specifically, the following volumes were higher in cases as compared to controls; total abdominal fat (19.4%), total intra-abdominal fat (49.7%), intra-peritoneal fat (47.7%), retroperitoneal fat (70.7%), pancreatic volume (26.6%), pancreatic volume index (21.3%) and liver span (10.8%).Importantly, increased pancreatic volume in patients was highly correlated with multiple measures of abdominal obesity and liver fat.

View Article: PubMed Central - PubMed

Affiliation: Centre of Nutrition & Metabolic Research (C-NET), National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Diabetes Foundation (India), SDA, New Delhi, India; Fortis C-DOC Centre of Excellence for Diabetes, Metabolic Diseases and Endocrinology, Chirag Enclave, Nehru place, New Delhi, India; Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India.

ABSTRACT

Objective: To evaluate body fat patterning and phenotype including hepatic fat and pancreatic volume of non-obese (BMI: < 25 kg/m2) Asian Indians with type 2 diabetes residing in North India.

Methods: Non-obese patients with type 2 diabetes (n = 93) and non-obese, normo-glycemic subjects (n = 40) were recruited. BMI, waist & hip circumferences, skinfold thickness at 8 sites, body fat, lean mass and detailed abdominal fat evaluation [total abdominal fat, total subcutaneous fat (superficial, deep, anterior, and posterior), total intra-abdominal fat (intra-peritoneal, retroperitoneal)], liver span, grades of fatty liver and pancreatic volume were compared.

Results: Waist circumference, subscapular skinfolds and total truncal fat (on DEXA) were higher whereas calf, total peripheral skinfolds and total leg fat (on DEXA) lower in patients. Specifically, the following volumes were higher in cases as compared to controls; total abdominal fat (19.4%), total intra-abdominal fat (49.7%), intra-peritoneal fat (47.7%), retroperitoneal fat (70.7%), pancreatic volume (26.6%), pancreatic volume index (21.3%) and liver span (10.8%). In cases, significant positive correlations were observed for pancreatic volume with BMI, waist and hip circumferences, W-HR, subscapular, abdominal and total truncal skinfolds, truncal, total subcutaneous, total intra-abdominal, intra-peritoneal, retroperitoneal fat depots, liver span and fatty liver.

Conclusions: In non-obese Asian Indians with type 2 diabetes, subcutaneous and intra-abdominal obesity, including fatty liver, and pancreatic volume were higher and peripheral subcutaneous adiposity was lower than BMI matched non-diabetic subjects. Importantly, increased pancreatic volume in patients was highly correlated with multiple measures of abdominal obesity and liver fat.

No MeSH data available.


Related in: MedlinePlus