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No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke.

Geurts M, van der Worp HB, Horsch AD, Kappelle LJ, Biessels GJ, Velthuis BK, DUST investigato - PLoS ONE (2015)

Bottom Line: There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1°Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70).Results for patients treated or not treated with alteplase were essentially the same.Our findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

ABSTRACT

Background: Recanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.

Methods: We included 278 patients with acute ischaemic stroke within nine hours after symptom onset, who had an intracranial arterial occlusion on admission CT angiography, in 13 participating centres. We calculated the relation per every 0.1°Celsius increase in admission body temperature and recanalization at three days.

Results: Recanalization occurred in 80% of occluded arteries. There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1°Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70). Results for patients treated or not treated with alteplase were essentially the same.

Conclusions: Our findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

No MeSH data available.


Related in: MedlinePlus

Odds ratios for the relation between body temperature on admission and recanalization.
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pone.0140777.g001: Odds ratios for the relation between body temperature on admission and recanalization.

Mentions: Body temperature on admission was not associated with recanalization (OR per 0.1°C, 0.98; 95%CI, 0.93–1.03; P = 0.39; adjusted OR (aOR) per 0.1°C, 0.99; 95%CI, 0.94–1.05; P = 0.70) (Table 2, Fig 1), nor with poor outcome (OR per 0.1°C, 0.97; 95%CI, 0.93–1.01; P = 0.09).


No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke.

Geurts M, van der Worp HB, Horsch AD, Kappelle LJ, Biessels GJ, Velthuis BK, DUST investigato - PLoS ONE (2015)

Odds ratios for the relation between body temperature on admission and recanalization.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608560&req=5

pone.0140777.g001: Odds ratios for the relation between body temperature on admission and recanalization.
Mentions: Body temperature on admission was not associated with recanalization (OR per 0.1°C, 0.98; 95%CI, 0.93–1.03; P = 0.39; adjusted OR (aOR) per 0.1°C, 0.99; 95%CI, 0.94–1.05; P = 0.70) (Table 2, Fig 1), nor with poor outcome (OR per 0.1°C, 0.97; 95%CI, 0.93–1.01; P = 0.09).

Bottom Line: There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1°Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70).Results for patients treated or not treated with alteplase were essentially the same.Our findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

ABSTRACT

Background: Recanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.

Methods: We included 278 patients with acute ischaemic stroke within nine hours after symptom onset, who had an intracranial arterial occlusion on admission CT angiography, in 13 participating centres. We calculated the relation per every 0.1°Celsius increase in admission body temperature and recanalization at three days.

Results: Recanalization occurred in 80% of occluded arteries. There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1°Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70). Results for patients treated or not treated with alteplase were essentially the same.

Conclusions: Our findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

No MeSH data available.


Related in: MedlinePlus