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Resistance Exercise Attenuates High-Fructose, High-Fat-Induced Postprandial Lipemia.

Wilburn JR, Bourquin J, Wysong A, Melby CL - Nutr Metab Insights (2015)

Bottom Line: Meals rich in both fructose and fat are commonly consumed by many Americans, especially young men, which can produce a significant postprandial lipemic response.The six-hour postprandial plasma insulin and lactate responses did not differ between conditions.However, the postprandial plasma TAG concentrations were 16.5% and 24.4% lower for EX-COMP (551.0 ± 80.5 mg/dL × 360 minutes) and EX-DEF (499.4 ± 73.5 mg/dL × 360 minutes), respectively, compared to CON (660.2 ± 95.0 mg/dL × 360 minutes) (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Human Nutrition, Nutrition and Metabolic Fitness Laboratory, Colorado State University, Fort Collins, CO, USA.

ABSTRACT

Introduction: Meals rich in both fructose and fat are commonly consumed by many Americans, especially young men, which can produce a significant postprandial lipemic response. Increasing evidence suggests that aerobic exercise can attenuate the postprandial increase in plasma triacylglycerols (TAGs) in response to a high-fat or a high-fructose meal. However, it is unknown if resistance exercise can dampen the postprandial lipemic response to a meal rich in both fructose and fat.

Methods: Eight apparently healthy men (Mean ± SEM; age = 27 ± 2 years) participated in a crossover study to examine the effects of acute resistance exercise on next-day postprandial lipemia resulting from a high-fructose, high-fat meal. Participants completed three separate two-day conditions in a random order: (1) EX-COMP: a full-body weightlifting workout with the provision of additional kilocalories to compensate for the estimated net energy cost of exercise on day 1, followed by the consumption of a high-fructose, high-fat liquid test meal the next morning (day 2) (~600 kcal) and the determination of the plasma glucose, lactate, insulin, and TAG responses during a six-hour postprandial period; (2) EX-DEF: same condition as EX-COMP but without exercise energy compensation on day 1; and (3) CON: no exercise control.

Results: The six-hour postprandial plasma insulin and lactate responses did not differ between conditions. However, the postprandial plasma TAG concentrations were 16.5% and 24.4% lower for EX-COMP (551.0 ± 80.5 mg/dL × 360 minutes) and EX-DEF (499.4 ± 73.5 mg/dL × 360 minutes), respectively, compared to CON (660.2 ± 95.0 mg/dL × 360 minutes) (P < 0.05).

Conclusions: A single resistance exercise bout, performed ~15 hours prior to a high-fructose, high-fat meal, attenuated the postprandial TAG response, as compared to a no-exercise control condition, in healthy, resistance-trained men.

No MeSH data available.


Related in: MedlinePlus

Plasma TAG concentrations. (A) During the six-hour postprandial period in response to a high-fructose, high-fat liquid meal, there was a significant condition by time interaction for plasma TAG concentrations (mean ± SEM), with baseline samples representing fasted values. Post hoc tests revealed that the mean concentrations over the six-hour period were significantly lower in EX-COMP and EX-DEF than in CON (P < 0.05) (*P < 0.05 for CON vs. EX-COMP; #P < 0.05 for CON vs. EX-DEF). (B) AUC (mean ± SEM) for plasma TAG concentrations, calculated using the trapezoidal rule, over the six-hour postprandial period (*P < 0.05, compared to CON).
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f2-nmi-8-2015-029: Plasma TAG concentrations. (A) During the six-hour postprandial period in response to a high-fructose, high-fat liquid meal, there was a significant condition by time interaction for plasma TAG concentrations (mean ± SEM), with baseline samples representing fasted values. Post hoc tests revealed that the mean concentrations over the six-hour period were significantly lower in EX-COMP and EX-DEF than in CON (P < 0.05) (*P < 0.05 for CON vs. EX-COMP; #P < 0.05 for CON vs. EX-DEF). (B) AUC (mean ± SEM) for plasma TAG concentrations, calculated using the trapezoidal rule, over the six-hour postprandial period (*P < 0.05, compared to CON).

Mentions: The TAG data are presented in Figure 2. There was not a significant difference in fasting plasma TAG across the three conditions. As expected, there was a significant time effect across the three conditions owing to the rise and subsequent fall of TAG during the postprandial period. The repeated measures ANOVA revealed a significant time by condition interaction with contrasts, showing both EX-COMP and EX-DEF to be significantly lower than CON (P < 0.05), but no differences between EX-COMP and EX-DEF. Post hoc tests revealed differences at several time points that were statistically significant (P < 0.05) between CON and EX-COMP and CON and EX-DEF, as shown in Figure 2. Additionally, the total six-hour AUC for TAG was significantly lower for both the EX-COMP and the EX-DEF conditions as compared to the CON condition (P < 0.05).


Resistance Exercise Attenuates High-Fructose, High-Fat-Induced Postprandial Lipemia.

Wilburn JR, Bourquin J, Wysong A, Melby CL - Nutr Metab Insights (2015)

Plasma TAG concentrations. (A) During the six-hour postprandial period in response to a high-fructose, high-fat liquid meal, there was a significant condition by time interaction for plasma TAG concentrations (mean ± SEM), with baseline samples representing fasted values. Post hoc tests revealed that the mean concentrations over the six-hour period were significantly lower in EX-COMP and EX-DEF than in CON (P < 0.05) (*P < 0.05 for CON vs. EX-COMP; #P < 0.05 for CON vs. EX-DEF). (B) AUC (mean ± SEM) for plasma TAG concentrations, calculated using the trapezoidal rule, over the six-hour postprandial period (*P < 0.05, compared to CON).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4608555&req=5

f2-nmi-8-2015-029: Plasma TAG concentrations. (A) During the six-hour postprandial period in response to a high-fructose, high-fat liquid meal, there was a significant condition by time interaction for plasma TAG concentrations (mean ± SEM), with baseline samples representing fasted values. Post hoc tests revealed that the mean concentrations over the six-hour period were significantly lower in EX-COMP and EX-DEF than in CON (P < 0.05) (*P < 0.05 for CON vs. EX-COMP; #P < 0.05 for CON vs. EX-DEF). (B) AUC (mean ± SEM) for plasma TAG concentrations, calculated using the trapezoidal rule, over the six-hour postprandial period (*P < 0.05, compared to CON).
Mentions: The TAG data are presented in Figure 2. There was not a significant difference in fasting plasma TAG across the three conditions. As expected, there was a significant time effect across the three conditions owing to the rise and subsequent fall of TAG during the postprandial period. The repeated measures ANOVA revealed a significant time by condition interaction with contrasts, showing both EX-COMP and EX-DEF to be significantly lower than CON (P < 0.05), but no differences between EX-COMP and EX-DEF. Post hoc tests revealed differences at several time points that were statistically significant (P < 0.05) between CON and EX-COMP and CON and EX-DEF, as shown in Figure 2. Additionally, the total six-hour AUC for TAG was significantly lower for both the EX-COMP and the EX-DEF conditions as compared to the CON condition (P < 0.05).

Bottom Line: Meals rich in both fructose and fat are commonly consumed by many Americans, especially young men, which can produce a significant postprandial lipemic response.The six-hour postprandial plasma insulin and lactate responses did not differ between conditions.However, the postprandial plasma TAG concentrations were 16.5% and 24.4% lower for EX-COMP (551.0 ± 80.5 mg/dL × 360 minutes) and EX-DEF (499.4 ± 73.5 mg/dL × 360 minutes), respectively, compared to CON (660.2 ± 95.0 mg/dL × 360 minutes) (P < 0.05).

View Article: PubMed Central - PubMed

Affiliation: Department of Food Science and Human Nutrition, Nutrition and Metabolic Fitness Laboratory, Colorado State University, Fort Collins, CO, USA.

ABSTRACT

Introduction: Meals rich in both fructose and fat are commonly consumed by many Americans, especially young men, which can produce a significant postprandial lipemic response. Increasing evidence suggests that aerobic exercise can attenuate the postprandial increase in plasma triacylglycerols (TAGs) in response to a high-fat or a high-fructose meal. However, it is unknown if resistance exercise can dampen the postprandial lipemic response to a meal rich in both fructose and fat.

Methods: Eight apparently healthy men (Mean ± SEM; age = 27 ± 2 years) participated in a crossover study to examine the effects of acute resistance exercise on next-day postprandial lipemia resulting from a high-fructose, high-fat meal. Participants completed three separate two-day conditions in a random order: (1) EX-COMP: a full-body weightlifting workout with the provision of additional kilocalories to compensate for the estimated net energy cost of exercise on day 1, followed by the consumption of a high-fructose, high-fat liquid test meal the next morning (day 2) (~600 kcal) and the determination of the plasma glucose, lactate, insulin, and TAG responses during a six-hour postprandial period; (2) EX-DEF: same condition as EX-COMP but without exercise energy compensation on day 1; and (3) CON: no exercise control.

Results: The six-hour postprandial plasma insulin and lactate responses did not differ between conditions. However, the postprandial plasma TAG concentrations were 16.5% and 24.4% lower for EX-COMP (551.0 ± 80.5 mg/dL × 360 minutes) and EX-DEF (499.4 ± 73.5 mg/dL × 360 minutes), respectively, compared to CON (660.2 ± 95.0 mg/dL × 360 minutes) (P < 0.05).

Conclusions: A single resistance exercise bout, performed ~15 hours prior to a high-fructose, high-fat meal, attenuated the postprandial TAG response, as compared to a no-exercise control condition, in healthy, resistance-trained men.

No MeSH data available.


Related in: MedlinePlus