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Postoperative intensity-modulated radiation therapy provides favorable local control and low toxicities in patients with soft tissue sarcomas in the extremities and trunk wall.

Wang J, Wang S, Song Y, Liu X, Jin J, Wang W, Yu Z, Liu Y, Li Y - Onco Targets Ther (2015)

Bottom Line: The patients with negative margins exhibited much better LC than did those with positive margins (90% vs 64.8%, P=0.023).Large tumor size (>5 cm) was significantly associated with poor overall survival.Edema and joint stiffness were observed in 17.6% and 9.8% of patients with extremity STSs, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

ABSTRACT

Purpose: To investigate the efficacy and toxicity of postoperative intensity-modulated radiation therapy (IMRT) for patients with soft tissue sarcomas (STSs) in the extremities and trunk wall.

Patients and methods: Eighty patients with localized STSs in the extremities and trunk wall treated with function-conserving surgery and postoperative IMRT were analyzed. The primary locations were in the extremities in 51 patients and in the trunk wall in 29 patients. The margins were positive in nine patients and negative in 71 patients. The median dose of IMRT was 64 Gy.

Results: At a median follow-up time of 38 months, eight patients developed local recurrences. The 5-year local control (LC) rate was 88.1%. The patients with negative margins exhibited much better LC than did those with positive margins (90% vs 64.8%, P=0.023). Multivariate analysis revealed that positive margin was an independent risk factor for LC. The 5-year distant metastasis-free survival, disease-free survival, and overall survival rates were 75.2%, 72.6%, and 83.6%, respectively. Large tumor size (>5 cm) was significantly associated with poor overall survival. Edema and joint stiffness were observed in 17.6% and 9.8% of patients with extremity STSs, respectively.

Conclusion: IMRT provides excellent LC and low toxicity for patients with STSs in the extremities and trunk wall.

No MeSH data available.


Related in: MedlinePlus

Local control (LC) and overall survival (OS) for all patients.
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f1-ott-8-2843: Local control (LC) and overall survival (OS) for all patients.

Mentions: Among the 80 patients, eight patients developed local recurrence with (n=2) or without (n=6) distant metastasis. The actual 3-year LC rate was 92.9%, and the estimated 5-year LC rate was 88.1% for all patients (Figure 1). Incomplete resection and male sex were associated with local recurrence (Table 2). Patient with positive margins exhibited significantly more local recurrence than did those with negative margins. The 5-year LC rates were 90% for the patients with negative margins (R0 resection) and 64.8% for those with positive margins (R1 + R2 resection, P=0.023). The 5-year LC rates were 100% for women and 80.0% for men (P=0.032). Multivariate analysis revealed that only positive margin (hazard ratio 5.33, 95% confidence interval 1.19–23.86, P=0.029) exerted an independent adverse influence on LC.


Postoperative intensity-modulated radiation therapy provides favorable local control and low toxicities in patients with soft tissue sarcomas in the extremities and trunk wall.

Wang J, Wang S, Song Y, Liu X, Jin J, Wang W, Yu Z, Liu Y, Li Y - Onco Targets Ther (2015)

Local control (LC) and overall survival (OS) for all patients.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4608545&req=5

f1-ott-8-2843: Local control (LC) and overall survival (OS) for all patients.
Mentions: Among the 80 patients, eight patients developed local recurrence with (n=2) or without (n=6) distant metastasis. The actual 3-year LC rate was 92.9%, and the estimated 5-year LC rate was 88.1% for all patients (Figure 1). Incomplete resection and male sex were associated with local recurrence (Table 2). Patient with positive margins exhibited significantly more local recurrence than did those with negative margins. The 5-year LC rates were 90% for the patients with negative margins (R0 resection) and 64.8% for those with positive margins (R1 + R2 resection, P=0.023). The 5-year LC rates were 100% for women and 80.0% for men (P=0.032). Multivariate analysis revealed that only positive margin (hazard ratio 5.33, 95% confidence interval 1.19–23.86, P=0.029) exerted an independent adverse influence on LC.

Bottom Line: The patients with negative margins exhibited much better LC than did those with positive margins (90% vs 64.8%, P=0.023).Large tumor size (>5 cm) was significantly associated with poor overall survival.Edema and joint stiffness were observed in 17.6% and 9.8% of patients with extremity STSs, respectively.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

ABSTRACT

Purpose: To investigate the efficacy and toxicity of postoperative intensity-modulated radiation therapy (IMRT) for patients with soft tissue sarcomas (STSs) in the extremities and trunk wall.

Patients and methods: Eighty patients with localized STSs in the extremities and trunk wall treated with function-conserving surgery and postoperative IMRT were analyzed. The primary locations were in the extremities in 51 patients and in the trunk wall in 29 patients. The margins were positive in nine patients and negative in 71 patients. The median dose of IMRT was 64 Gy.

Results: At a median follow-up time of 38 months, eight patients developed local recurrences. The 5-year local control (LC) rate was 88.1%. The patients with negative margins exhibited much better LC than did those with positive margins (90% vs 64.8%, P=0.023). Multivariate analysis revealed that positive margin was an independent risk factor for LC. The 5-year distant metastasis-free survival, disease-free survival, and overall survival rates were 75.2%, 72.6%, and 83.6%, respectively. Large tumor size (>5 cm) was significantly associated with poor overall survival. Edema and joint stiffness were observed in 17.6% and 9.8% of patients with extremity STSs, respectively.

Conclusion: IMRT provides excellent LC and low toxicity for patients with STSs in the extremities and trunk wall.

No MeSH data available.


Related in: MedlinePlus