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Tris-(2,3-Dibromopropyl) Isocyanurate, a New Emerging Pollutant, Impairs Cognition and Provokes Depression-Like Behaviors in Adult Rats.

Ye L, Hu Z, Wang H, Zhu H, Dong Z, Jiang W, Zhao H, Li N, Mi W, Wang W, Hu X - PLoS ONE (2015)

Bottom Line: TDBP-TAZTO can pass through the blood brain barrier and accumulate in brain.We hypothesize that TDBP-TAZTO could induce the neurotoxicity in rat hippocampal neurons.TDBP-TAZTO resulted in cognitive impairment and depression-like behaviors, which may be related with TDBP-TAZTO-induced hypothalamic-pituitary-adrenal axis hyperactivation, upregulation of inflammatory and oxidative stress markers, overexpression of pro-apoptotic proteins, downexpression of neurogenesis-related proteins in hippocampus, and hippocampal neurons damage in DG, CA1 and CA3 areas.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China; Institute of Toxicology, Binzhou Medical University, Yantai, Shandong, PR China.

ABSTRACT
Tris-(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO), an emerging brominated flame retardant, possesses the characteristics of candidate persistent organic pollutants and has displayed toxicity to fish and rodents. TDBP-TAZTO can pass through the blood brain barrier and accumulate in brain. However, the neurotoxicity of TDBP-TAZTO has not yet studied in rodents. We hypothesize that TDBP-TAZTO could induce the neurotoxicity in rat hippocampal neurons. The male adult rats were exposed to TDBP-TAZTO of 5 and 50 mg/kg by gavage, daily for 6 months. TDBP-TAZTO resulted in cognitive impairment and depression-like behaviors, which may be related with TDBP-TAZTO-induced hypothalamic-pituitary-adrenal axis hyperactivation, upregulation of inflammatory and oxidative stress markers, overexpression of pro-apoptotic proteins, downexpression of neurogenesis-related proteins in hippocampus, and hippocampal neurons damage in DG, CA1 and CA3 areas. Our findings suggested that TDBP-TAZTO induces significant hippocampal neurotoxicity, which provokes cognitive impairment and depression-like behaviors in adult rats. Therefore, this research will contribute to evaluate the neurotoxic effects of TDBP-TAZTO in human.

No MeSH data available.


Related in: MedlinePlus

The effects of TDBP-TAZTO (5 and 50 mg/kg) on spatial learning and memory in rats in the Morris water test.(A) In the acquisition trial, TDBP-TAZTO rats showed an increased latency to the platform. (B) In the probe trial, TDBP-TAZTO rats had a decreased time spent in the target quadrant. (C) From day 1 to day 6, TDBP-TAZTO did not affect the swimming speed compared with that in control group. Data ate expressed as mean ± SE (n = 10/group). ap < 0.05, TDBP-TAZTO 5 mg/kg group vs. control group; bp < 0.05, TDBP-TAZTO 50 mg/kg group vs. control group.
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pone.0140281.g003: The effects of TDBP-TAZTO (5 and 50 mg/kg) on spatial learning and memory in rats in the Morris water test.(A) In the acquisition trial, TDBP-TAZTO rats showed an increased latency to the platform. (B) In the probe trial, TDBP-TAZTO rats had a decreased time spent in the target quadrant. (C) From day 1 to day 6, TDBP-TAZTO did not affect the swimming speed compared with that in control group. Data ate expressed as mean ± SE (n = 10/group). ap < 0.05, TDBP-TAZTO 5 mg/kg group vs. control group; bp < 0.05, TDBP-TAZTO 50 mg/kg group vs. control group.

Mentions: In MWM test, the escape time in the acquisition trial showed statistically significant differences among the groups on the 4th and 5th days [F (2, 27) = 5.10, p = 0.013; F (2, 27) = 7.82, p = 0.002, respectively]. On both time points, the escape time in TDBP-TAZTO groups were significantly increased compared with that in control group (each p < 0.05) (Fig 3A).


Tris-(2,3-Dibromopropyl) Isocyanurate, a New Emerging Pollutant, Impairs Cognition and Provokes Depression-Like Behaviors in Adult Rats.

Ye L, Hu Z, Wang H, Zhu H, Dong Z, Jiang W, Zhao H, Li N, Mi W, Wang W, Hu X - PLoS ONE (2015)

The effects of TDBP-TAZTO (5 and 50 mg/kg) on spatial learning and memory in rats in the Morris water test.(A) In the acquisition trial, TDBP-TAZTO rats showed an increased latency to the platform. (B) In the probe trial, TDBP-TAZTO rats had a decreased time spent in the target quadrant. (C) From day 1 to day 6, TDBP-TAZTO did not affect the swimming speed compared with that in control group. Data ate expressed as mean ± SE (n = 10/group). ap < 0.05, TDBP-TAZTO 5 mg/kg group vs. control group; bp < 0.05, TDBP-TAZTO 50 mg/kg group vs. control group.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4601767&req=5

pone.0140281.g003: The effects of TDBP-TAZTO (5 and 50 mg/kg) on spatial learning and memory in rats in the Morris water test.(A) In the acquisition trial, TDBP-TAZTO rats showed an increased latency to the platform. (B) In the probe trial, TDBP-TAZTO rats had a decreased time spent in the target quadrant. (C) From day 1 to day 6, TDBP-TAZTO did not affect the swimming speed compared with that in control group. Data ate expressed as mean ± SE (n = 10/group). ap < 0.05, TDBP-TAZTO 5 mg/kg group vs. control group; bp < 0.05, TDBP-TAZTO 50 mg/kg group vs. control group.
Mentions: In MWM test, the escape time in the acquisition trial showed statistically significant differences among the groups on the 4th and 5th days [F (2, 27) = 5.10, p = 0.013; F (2, 27) = 7.82, p = 0.002, respectively]. On both time points, the escape time in TDBP-TAZTO groups were significantly increased compared with that in control group (each p < 0.05) (Fig 3A).

Bottom Line: TDBP-TAZTO can pass through the blood brain barrier and accumulate in brain.We hypothesize that TDBP-TAZTO could induce the neurotoxicity in rat hippocampal neurons.TDBP-TAZTO resulted in cognitive impairment and depression-like behaviors, which may be related with TDBP-TAZTO-induced hypothalamic-pituitary-adrenal axis hyperactivation, upregulation of inflammatory and oxidative stress markers, overexpression of pro-apoptotic proteins, downexpression of neurogenesis-related proteins in hippocampus, and hippocampal neurons damage in DG, CA1 and CA3 areas.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health and Management, Binzhou Medical University, Yantai, Shandong, PR China; Institute of Toxicology, Binzhou Medical University, Yantai, Shandong, PR China.

ABSTRACT
Tris-(2,3-dibromopropyl) isocyanurate (TDBP-TAZTO), an emerging brominated flame retardant, possesses the characteristics of candidate persistent organic pollutants and has displayed toxicity to fish and rodents. TDBP-TAZTO can pass through the blood brain barrier and accumulate in brain. However, the neurotoxicity of TDBP-TAZTO has not yet studied in rodents. We hypothesize that TDBP-TAZTO could induce the neurotoxicity in rat hippocampal neurons. The male adult rats were exposed to TDBP-TAZTO of 5 and 50 mg/kg by gavage, daily for 6 months. TDBP-TAZTO resulted in cognitive impairment and depression-like behaviors, which may be related with TDBP-TAZTO-induced hypothalamic-pituitary-adrenal axis hyperactivation, upregulation of inflammatory and oxidative stress markers, overexpression of pro-apoptotic proteins, downexpression of neurogenesis-related proteins in hippocampus, and hippocampal neurons damage in DG, CA1 and CA3 areas. Our findings suggested that TDBP-TAZTO induces significant hippocampal neurotoxicity, which provokes cognitive impairment and depression-like behaviors in adult rats. Therefore, this research will contribute to evaluate the neurotoxic effects of TDBP-TAZTO in human.

No MeSH data available.


Related in: MedlinePlus