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First evidence for glial pathology in late life minor depression: S100B is increased in males with minor depression.

Polyakova M, Sander C, Arelin K, Lampe L, Luck T, Luppa M, Kratzsch J, Hoffmann KT, Riedel-Heller S, Villringer A, Schoenknecht P, Schroeter ML - Front Cell Neurosci (2015)

Bottom Line: S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10-0.66).S100B correlated with BMI (rs = 0.246, p = 0.031) and with age in healthy subjects (rs = 0.345, p = 0.002).Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany ; University Clinic for Psychiatry and Psychotherapy, Leipzig University Leipzig, Germany ; LIFE-Leipzig Rsearch Center for Civilization Diseases, Leipzig University Leipzig, Germany.

ABSTRACT
Minor depression is diagnosed when a patient suffers from 2 to 4 depressive symptoms for at least 2 weeks. Though minor depression is a widespread phenomenon, its pathophysiology has hardly been studied. To get a first insight into the pathophysiological mechanisms underlying this disorder we assessed serum levels of biomarkers for plasticity, glial and neuronal function: brain-derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE). 27 subjects with minor depressive episode and 82 healthy subjects over 60 years of age were selected from the database of the Leipzig population-based study of civilization diseases (LIFE). Serum levels of BDNF, S100B and NSE were compared between groups, and correlated with age, body-mass index (BMI), and degree of white matter hyperintensities (score on Fazekas scale). S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10-0.66). NSE correlated with Fazekas score in patients with minor depression (rs = 0.436, p = 0.048) and in the whole sample (rs = 0.252, p = 0.019). S100B correlated with BMI (rs = 0.246, p = 0.031) and with age in healthy subjects (rs = 0.345, p = 0.002). Increased S100B in males with minor depression, without alterations in BDNF and NSE, supports the glial hypothesis of depression. Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

No MeSH data available.


Related in: MedlinePlus

Dot plot for the distribution of serum markers’ levels in subjects and healthy controls (first row), separately for males (second row), and females (third row). Median levels of the serum markers are depicted with black horizontal lines. Note that the distribution of S100B in males is depicted on a zoomed scale. MinD, minor depression; HC, healthy controls; BDNF, brain derived neurotrophic factor; NSE, neuron specific enolase.
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Figure 1: Dot plot for the distribution of serum markers’ levels in subjects and healthy controls (first row), separately for males (second row), and females (third row). Median levels of the serum markers are depicted with black horizontal lines. Note that the distribution of S100B in males is depicted on a zoomed scale. MinD, minor depression; HC, healthy controls; BDNF, brain derived neurotrophic factor; NSE, neuron specific enolase.

Mentions: BDNF, S100B and NSE did not differ between patients in minor depressive episode and healthy control subjects (Table 1). Since the two groups differed with regard to sex, we conducted additionally sex-specific analyses. Figure 1 illustrates results with dot plots for the three serum marker proteins across the whole groups, and specifically for each sex. When the analysis was stratified by sex we observed significantly increased S100B (p = 0.034) in males with minor depressive episode (0.092 μg/l [0.012]) in comparison with healthy male controls (0.067 μg/l [0.004]).


First evidence for glial pathology in late life minor depression: S100B is increased in males with minor depression.

Polyakova M, Sander C, Arelin K, Lampe L, Luck T, Luppa M, Kratzsch J, Hoffmann KT, Riedel-Heller S, Villringer A, Schoenknecht P, Schroeter ML - Front Cell Neurosci (2015)

Dot plot for the distribution of serum markers’ levels in subjects and healthy controls (first row), separately for males (second row), and females (third row). Median levels of the serum markers are depicted with black horizontal lines. Note that the distribution of S100B in males is depicted on a zoomed scale. MinD, minor depression; HC, healthy controls; BDNF, brain derived neurotrophic factor; NSE, neuron specific enolase.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4598479&req=5

Figure 1: Dot plot for the distribution of serum markers’ levels in subjects and healthy controls (first row), separately for males (second row), and females (third row). Median levels of the serum markers are depicted with black horizontal lines. Note that the distribution of S100B in males is depicted on a zoomed scale. MinD, minor depression; HC, healthy controls; BDNF, brain derived neurotrophic factor; NSE, neuron specific enolase.
Mentions: BDNF, S100B and NSE did not differ between patients in minor depressive episode and healthy control subjects (Table 1). Since the two groups differed with regard to sex, we conducted additionally sex-specific analyses. Figure 1 illustrates results with dot plots for the three serum marker proteins across the whole groups, and specifically for each sex. When the analysis was stratified by sex we observed significantly increased S100B (p = 0.034) in males with minor depressive episode (0.092 μg/l [0.012]) in comparison with healthy male controls (0.067 μg/l [0.004]).

Bottom Line: S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10-0.66).S100B correlated with BMI (rs = 0.246, p = 0.031) and with age in healthy subjects (rs = 0.345, p = 0.002).Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany ; University Clinic for Psychiatry and Psychotherapy, Leipzig University Leipzig, Germany ; LIFE-Leipzig Rsearch Center for Civilization Diseases, Leipzig University Leipzig, Germany.

ABSTRACT
Minor depression is diagnosed when a patient suffers from 2 to 4 depressive symptoms for at least 2 weeks. Though minor depression is a widespread phenomenon, its pathophysiology has hardly been studied. To get a first insight into the pathophysiological mechanisms underlying this disorder we assessed serum levels of biomarkers for plasticity, glial and neuronal function: brain-derived neurotrophic factor (BDNF), S100B and neuron specific enolase (NSE). 27 subjects with minor depressive episode and 82 healthy subjects over 60 years of age were selected from the database of the Leipzig population-based study of civilization diseases (LIFE). Serum levels of BDNF, S100B and NSE were compared between groups, and correlated with age, body-mass index (BMI), and degree of white matter hyperintensities (score on Fazekas scale). S100B was significantly increased in males with minor depression in comparison to healthy males, whereas other biomarkers did not differ between groups (p = 0.10-0.66). NSE correlated with Fazekas score in patients with minor depression (rs = 0.436, p = 0.048) and in the whole sample (rs = 0.252, p = 0.019). S100B correlated with BMI (rs = 0.246, p = 0.031) and with age in healthy subjects (rs = 0.345, p = 0.002). Increased S100B in males with minor depression, without alterations in BDNF and NSE, supports the glial hypothesis of depression. Correlation between white matter hyperintensities and NSE underscores the vascular hypothesis of late life depression.

No MeSH data available.


Related in: MedlinePlus