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Genetic variations in the serotonergic system contribute to amygdala volume in humans.

Li J, Chen C, Wu K, Zhang M, Zhu B, Chen C, Moyzis RK, Dong Q - Front Neuroanat (2015)

Bottom Line: Permutation analyses showed that the probability of obtaining these findings by chance was low (p = 0.043, permuted for 1000 times).Findings showed that serotonin genes contribute moderately to individual differences in amygdala volume in a healthy Chinese sample.These results indicate that the system-level approach can help us to understand the genetic basis of a complex trait such as amygdala structure.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University Beijing, China ; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences Beijing, China ; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences Beijing, China.

ABSTRACT
The amygdala plays a critical role in emotion processing and psychiatric disorders associated with emotion dysfunction. Accumulating evidence suggests that amygdala structure is modulated by serotonin-related genes. However, there is a gap between the small contributions of single loci (less than 1%) and the reported 63-65% heritability of amygdala structure. To understand the "missing heritability," we systematically explored the contribution of serotonin genes on amygdala structure at the gene set level. The present study of 417 healthy Chinese volunteers examined 129 representative polymorphisms in genes from multiple biological mechanisms in the regulation of serotonin neurotransmission. A system-level approach using multiple regression analyses identified that nine SNPs collectively accounted for approximately 8% of the variance in amygdala volume. Permutation analyses showed that the probability of obtaining these findings by chance was low (p = 0.043, permuted for 1000 times). Findings showed that serotonin genes contribute moderately to individual differences in amygdala volume in a healthy Chinese sample. These results indicate that the system-level approach can help us to understand the genetic basis of a complex trait such as amygdala structure.

No MeSH data available.


Related in: MedlinePlus

Permutation results for the genetic model: the dashed line represents the empirical distribution of R2 obtained from the randomized data, and the solid vertical line represents R2 obtained from the actual data.
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Figure 1: Permutation results for the genetic model: the dashed line represents the empirical distribution of R2 obtained from the randomized data, and the solid vertical line represents R2 obtained from the actual data.

Mentions: Finally Monte Carlo permutation analyses were carried out to test the model. Figure 1 shows the permutation results. Based on 1000 permutation tests, the probability of attaining the R2 or adjusted R2 found in the model reached significance (p = 0.043 and 0.044, respectively). These results indicate that genes in the serotonin system contribute substantially to individual variance in amygdala volume.


Genetic variations in the serotonergic system contribute to amygdala volume in humans.

Li J, Chen C, Wu K, Zhang M, Zhu B, Chen C, Moyzis RK, Dong Q - Front Neuroanat (2015)

Permutation results for the genetic model: the dashed line represents the empirical distribution of R2 obtained from the randomized data, and the solid vertical line represents R2 obtained from the actual data.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4598478&req=5

Figure 1: Permutation results for the genetic model: the dashed line represents the empirical distribution of R2 obtained from the randomized data, and the solid vertical line represents R2 obtained from the actual data.
Mentions: Finally Monte Carlo permutation analyses were carried out to test the model. Figure 1 shows the permutation results. Based on 1000 permutation tests, the probability of attaining the R2 or adjusted R2 found in the model reached significance (p = 0.043 and 0.044, respectively). These results indicate that genes in the serotonin system contribute substantially to individual variance in amygdala volume.

Bottom Line: Permutation analyses showed that the probability of obtaining these findings by chance was low (p = 0.043, permuted for 1000 times).Findings showed that serotonin genes contribute moderately to individual differences in amygdala volume in a healthy Chinese sample.These results indicate that the system-level approach can help us to understand the genetic basis of a complex trait such as amygdala structure.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University Beijing, China ; Brainnetome Center, Institute of Automation, Chinese Academy of Sciences Beijing, China ; National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences Beijing, China.

ABSTRACT
The amygdala plays a critical role in emotion processing and psychiatric disorders associated with emotion dysfunction. Accumulating evidence suggests that amygdala structure is modulated by serotonin-related genes. However, there is a gap between the small contributions of single loci (less than 1%) and the reported 63-65% heritability of amygdala structure. To understand the "missing heritability," we systematically explored the contribution of serotonin genes on amygdala structure at the gene set level. The present study of 417 healthy Chinese volunteers examined 129 representative polymorphisms in genes from multiple biological mechanisms in the regulation of serotonin neurotransmission. A system-level approach using multiple regression analyses identified that nine SNPs collectively accounted for approximately 8% of the variance in amygdala volume. Permutation analyses showed that the probability of obtaining these findings by chance was low (p = 0.043, permuted for 1000 times). Findings showed that serotonin genes contribute moderately to individual differences in amygdala volume in a healthy Chinese sample. These results indicate that the system-level approach can help us to understand the genetic basis of a complex trait such as amygdala structure.

No MeSH data available.


Related in: MedlinePlus