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Postranslational Modification of Ion Channels in Colonic Inflammation.

Akbarali HI, Kang M - Curr Neuropharmacol (2015)

Bottom Line: There is significant evidence that these channels are subject to modulation by redox status of the cells.In the setting of colonic inflammation, modifications of cysteine and tyrosine are likely to occur at several sites within the same channel complex.In this review we describe alterations in channel function due to specific modifications of tyrosine and cysteine residues by reactive nitrogen, oxygen and hydrogen-sulfide resulting in altered motility.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Virginia Commonwealth University, 1112 East Clay Street, McGuire Hall Rm# 317, Richmond, VA 23298, USA Country. hiakbarali@vcu.edu.

ABSTRACT
Voltage-gated ion channels are key regulators of cell excitability. There is significant evidence that these channels are subject to modulation by redox status of the cells. Here we review the post-translational modifications of ion channels that occur in colonic inflammation. The redox mechanisms involve tyrosine nitration, covalent modification of cysteine residues and sulfhydration by hydrogen sulfide in experimental colitis. In the setting of colonic inflammation, modifications of cysteine and tyrosine are likely to occur at several sites within the same channel complex. In this review we describe alterations in channel function due to specific modifications of tyrosine and cysteine residues by reactive nitrogen, oxygen and hydrogen-sulfide resulting in altered motility.

No MeSH data available.


Related in: MedlinePlus

A schematic representation of reactive nitrogen and oxygen species and their modification of specific amino acids within an ion channel complex.
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Figure 1: A schematic representation of reactive nitrogen and oxygen species and their modification of specific amino acids within an ion channel complex.


Postranslational Modification of Ion Channels in Colonic Inflammation.

Akbarali HI, Kang M - Curr Neuropharmacol (2015)

A schematic representation of reactive nitrogen and oxygen species and their modification of specific amino acids within an ion channel complex.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4598435&req=5

Figure 1: A schematic representation of reactive nitrogen and oxygen species and their modification of specific amino acids within an ion channel complex.
Bottom Line: There is significant evidence that these channels are subject to modulation by redox status of the cells.In the setting of colonic inflammation, modifications of cysteine and tyrosine are likely to occur at several sites within the same channel complex.In this review we describe alterations in channel function due to specific modifications of tyrosine and cysteine residues by reactive nitrogen, oxygen and hydrogen-sulfide resulting in altered motility.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmacology and Toxicology, Virginia Commonwealth University, 1112 East Clay Street, McGuire Hall Rm# 317, Richmond, VA 23298, USA Country. hiakbarali@vcu.edu.

ABSTRACT
Voltage-gated ion channels are key regulators of cell excitability. There is significant evidence that these channels are subject to modulation by redox status of the cells. Here we review the post-translational modifications of ion channels that occur in colonic inflammation. The redox mechanisms involve tyrosine nitration, covalent modification of cysteine residues and sulfhydration by hydrogen sulfide in experimental colitis. In the setting of colonic inflammation, modifications of cysteine and tyrosine are likely to occur at several sites within the same channel complex. In this review we describe alterations in channel function due to specific modifications of tyrosine and cysteine residues by reactive nitrogen, oxygen and hydrogen-sulfide resulting in altered motility.

No MeSH data available.


Related in: MedlinePlus