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Genomics and Evolution in Traditional Medicinal Plants: Road to a Healthier Life.

Hao DC, Xiao PG - Evol. Bioinform. Online (2015)

Bottom Line: Medicinal plants have long been utilized in traditional medicine and ethnomedicine worldwide.The utility of molecular phylogeny and phylogenomics in predicting chemodiversity and bioprospecting is also highlighted within the context of natural-product-based drug discovery and development.Representative case studies of medicinal plant genome, phylogeny, and evolution are summarized to exemplify the expansion of knowledge pedigree and the paradigm shift to the omics-based approaches, which update our awareness about plant genome evolution and enable the molecular breeding of medicinal plants and the sustainable utilization of plant pharmaceutical resources.

View Article: PubMed Central - PubMed

Affiliation: Biotechnology Institute, School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian, P. R. China.

ABSTRACT
Medicinal plants have long been utilized in traditional medicine and ethnomedicine worldwide. This review presents a glimpse of the current status of and future trends in medicinal plant genomics, evolution, and phylogeny. These dynamic fields are at the intersection of phytochemistry and plant biology and are concerned with the evolution mechanisms and systematics of medicinal plant genomes, origin and evolution of the plant genotype and metabolic phenotype, interaction between medicinal plant genomes and their environment, the correlation between genomic diversity and metabolite diversity, and so on. Use of the emerging high-end genomic technologies can be expanded from crop plants to traditional medicinal plants, in order to expedite medicinal plant breeding and transform them into living factories of medicinal compounds. The utility of molecular phylogeny and phylogenomics in predicting chemodiversity and bioprospecting is also highlighted within the context of natural-product-based drug discovery and development. Representative case studies of medicinal plant genome, phylogeny, and evolution are summarized to exemplify the expansion of knowledge pedigree and the paradigm shift to the omics-based approaches, which update our awareness about plant genome evolution and enable the molecular breeding of medicinal plants and the sustainable utilization of plant pharmaceutical resources.

No MeSH data available.


Omics data that could be used in the pharmacophylogeny inference.Abbreviations: RAD, restriction site associated DNA; SNP, single nucleotide polymorphism; SSR, simple sequence repeat; EST, expressed sequence tag.
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f6-ebo-11-2015-197: Omics data that could be used in the pharmacophylogeny inference.Abbreviations: RAD, restriction site associated DNA; SNP, single nucleotide polymorphism; SSR, simple sequence repeat; EST, expressed sequence tag.

Mentions: Diverse new terms are emerging in the genomic era, such as phylogenomics, pharmacophylogenomics, and phylotranscriptomics, which are somewhat overlapping with pharmaphylogeny (pharmacophylogeny/pharmacophylogenetics).48 Phylogenomics is the crossing of evolutionary biology and genomics, in which genome data are utilized for evolutionary reconstructions. Pharmaphylogeny, advocated by Pei-gen Xiao since the 1980s,101,102 focuses on the phylogenetic relationship of medicinal plants and aims to foster the sustainable utilization of TCM resources, and is thus nurtured by molecular phylogeny, chemotaxonomy, ethnopharmacology, and bioactivity studies (Fig. 6). Phylogenomics can be integrated into the pipeline of drug discovery and development, and extends the field of pharmaphylogeny at the omic level; thus the concept of pharmacophylogenomics, initially emphasizing the genomic analysis of the evolutionary history of drug targets,103 could be redefined as an upgraded version of pharmaphylogeny.


Genomics and Evolution in Traditional Medicinal Plants: Road to a Healthier Life.

Hao DC, Xiao PG - Evol. Bioinform. Online (2015)

Omics data that could be used in the pharmacophylogeny inference.Abbreviations: RAD, restriction site associated DNA; SNP, single nucleotide polymorphism; SSR, simple sequence repeat; EST, expressed sequence tag.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4597484&req=5

f6-ebo-11-2015-197: Omics data that could be used in the pharmacophylogeny inference.Abbreviations: RAD, restriction site associated DNA; SNP, single nucleotide polymorphism; SSR, simple sequence repeat; EST, expressed sequence tag.
Mentions: Diverse new terms are emerging in the genomic era, such as phylogenomics, pharmacophylogenomics, and phylotranscriptomics, which are somewhat overlapping with pharmaphylogeny (pharmacophylogeny/pharmacophylogenetics).48 Phylogenomics is the crossing of evolutionary biology and genomics, in which genome data are utilized for evolutionary reconstructions. Pharmaphylogeny, advocated by Pei-gen Xiao since the 1980s,101,102 focuses on the phylogenetic relationship of medicinal plants and aims to foster the sustainable utilization of TCM resources, and is thus nurtured by molecular phylogeny, chemotaxonomy, ethnopharmacology, and bioactivity studies (Fig. 6). Phylogenomics can be integrated into the pipeline of drug discovery and development, and extends the field of pharmaphylogeny at the omic level; thus the concept of pharmacophylogenomics, initially emphasizing the genomic analysis of the evolutionary history of drug targets,103 could be redefined as an upgraded version of pharmaphylogeny.

Bottom Line: Medicinal plants have long been utilized in traditional medicine and ethnomedicine worldwide.The utility of molecular phylogeny and phylogenomics in predicting chemodiversity and bioprospecting is also highlighted within the context of natural-product-based drug discovery and development.Representative case studies of medicinal plant genome, phylogeny, and evolution are summarized to exemplify the expansion of knowledge pedigree and the paradigm shift to the omics-based approaches, which update our awareness about plant genome evolution and enable the molecular breeding of medicinal plants and the sustainable utilization of plant pharmaceutical resources.

View Article: PubMed Central - PubMed

Affiliation: Biotechnology Institute, School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian, P. R. China.

ABSTRACT
Medicinal plants have long been utilized in traditional medicine and ethnomedicine worldwide. This review presents a glimpse of the current status of and future trends in medicinal plant genomics, evolution, and phylogeny. These dynamic fields are at the intersection of phytochemistry and plant biology and are concerned with the evolution mechanisms and systematics of medicinal plant genomes, origin and evolution of the plant genotype and metabolic phenotype, interaction between medicinal plant genomes and their environment, the correlation between genomic diversity and metabolite diversity, and so on. Use of the emerging high-end genomic technologies can be expanded from crop plants to traditional medicinal plants, in order to expedite medicinal plant breeding and transform them into living factories of medicinal compounds. The utility of molecular phylogeny and phylogenomics in predicting chemodiversity and bioprospecting is also highlighted within the context of natural-product-based drug discovery and development. Representative case studies of medicinal plant genome, phylogeny, and evolution are summarized to exemplify the expansion of knowledge pedigree and the paradigm shift to the omics-based approaches, which update our awareness about plant genome evolution and enable the molecular breeding of medicinal plants and the sustainable utilization of plant pharmaceutical resources.

No MeSH data available.