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A pilot comparison of phospolipidated lutein to conventional lutein for effects on plasma lutein concentrations in adult people.

DiSilvestro RA, Thomas S, Harrison E, Epitropoulos A - Nutr J (2015)

Bottom Line: Plasma lutein was measured pre- and post-supplementation as well as 7 days after supplementation stopped.The lutein complex showed superior effects based on absolute mean value after 10 days of supplementation, change in value from baseline to 10 days, and value at 7 days after supplement discontinuation.A solid lipid lutein complex strongly increased plasma lutein levels compared to a conventional form.

View Article: PubMed Central - PubMed

Affiliation: Columbus Nutraceutical Formulations LLC, 8050 Simfield Rd, Dublin, OH, 43016, USA. studies@columbus.rr.com.

ABSTRACT

Background: The percent absorption of lutein from supplements falls well below that from lutein enriched egg yolk, a rich source of phospholipids. Therefore, a supplement of lutein plus phospholipids was tested for effects on serum accumulation.

Methods: A 10 day supplementation with a solid-lipid particle (SLP) lutein complex or conventional lutein ester was done in apparently healthy people (both supplement types taken with fat containing meals). Plasma lutein was measured pre- and post-supplementation as well as 7 days after supplementation stopped. Changes within each supplement group were analyzed by paired t-test; group comparisons were done by unpaired t-test.

Results: The solid-lipid particle complex lutein gave much higher plasma lutein values than conventional lutein ester. The lutein complex showed superior effects based on absolute mean value after 10 days of supplementation, change in value from baseline to 10 days, and value at 7 days after supplement discontinuation.

Conclusions: A solid lipid lutein complex strongly increased plasma lutein levels compared to a conventional form.

No MeSH data available.


Related in: MedlinePlus

Plasma lutein concentrations 7 days post-supplementation (10 mg/day of lutein for 10 days). Lutein 1 = lutein ester. Lutein 2 = solid-lipid particle complex lutein. *Significantly different from Lutein1 value, p < 0.001, unpaired t-test
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Fig3: Plasma lutein concentrations 7 days post-supplementation (10 mg/day of lutein for 10 days). Lutein 1 = lutein ester. Lutein 2 = solid-lipid particle complex lutein. *Significantly different from Lutein1 value, p < 0.001, unpaired t-test

Mentions: After 10 days of supplementation, both supplements produced highly significant increases in plasma lutein values (Fig. 1, p < 0.001 for each treatment, paired t-test). The solid-lipid particle complex lutein gave a much higher mean plasma lutein value than conventional lutein (p < 0.001, unpaired t-test). The mean percent change versus pre-supplement values was 563 % for the solid-lipid particle complex lutein and 88 % for the conventional lutein ester. If the data was expressed as the change in lutein concentrations, a much higher mean change was seen with the solid-lipid particle complex (Fig. 2, p < 0.001, unpaired t-test). For both the conventional and new lutein supplement, mean plasma lutein levels remained above baseline 7 days after supplementation (Fig. 1, pre-values vs Fig. 3, p < 0.001, paired t-test). However, the solid-lipid particle complex lutein gave a much higher mean plasma lutein value (Fig. 3, p < 0.001, paired t-test). Thus, by three types of evaluations, plasma lutein concentrations responded to a much greater degree to the solid-lipid particle complex lutein than to a conventional version.Fig. 1


A pilot comparison of phospolipidated lutein to conventional lutein for effects on plasma lutein concentrations in adult people.

DiSilvestro RA, Thomas S, Harrison E, Epitropoulos A - Nutr J (2015)

Plasma lutein concentrations 7 days post-supplementation (10 mg/day of lutein for 10 days). Lutein 1 = lutein ester. Lutein 2 = solid-lipid particle complex lutein. *Significantly different from Lutein1 value, p < 0.001, unpaired t-test
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4597392&req=5

Fig3: Plasma lutein concentrations 7 days post-supplementation (10 mg/day of lutein for 10 days). Lutein 1 = lutein ester. Lutein 2 = solid-lipid particle complex lutein. *Significantly different from Lutein1 value, p < 0.001, unpaired t-test
Mentions: After 10 days of supplementation, both supplements produced highly significant increases in plasma lutein values (Fig. 1, p < 0.001 for each treatment, paired t-test). The solid-lipid particle complex lutein gave a much higher mean plasma lutein value than conventional lutein (p < 0.001, unpaired t-test). The mean percent change versus pre-supplement values was 563 % for the solid-lipid particle complex lutein and 88 % for the conventional lutein ester. If the data was expressed as the change in lutein concentrations, a much higher mean change was seen with the solid-lipid particle complex (Fig. 2, p < 0.001, unpaired t-test). For both the conventional and new lutein supplement, mean plasma lutein levels remained above baseline 7 days after supplementation (Fig. 1, pre-values vs Fig. 3, p < 0.001, paired t-test). However, the solid-lipid particle complex lutein gave a much higher mean plasma lutein value (Fig. 3, p < 0.001, paired t-test). Thus, by three types of evaluations, plasma lutein concentrations responded to a much greater degree to the solid-lipid particle complex lutein than to a conventional version.Fig. 1

Bottom Line: Plasma lutein was measured pre- and post-supplementation as well as 7 days after supplementation stopped.The lutein complex showed superior effects based on absolute mean value after 10 days of supplementation, change in value from baseline to 10 days, and value at 7 days after supplement discontinuation.A solid lipid lutein complex strongly increased plasma lutein levels compared to a conventional form.

View Article: PubMed Central - PubMed

Affiliation: Columbus Nutraceutical Formulations LLC, 8050 Simfield Rd, Dublin, OH, 43016, USA. studies@columbus.rr.com.

ABSTRACT

Background: The percent absorption of lutein from supplements falls well below that from lutein enriched egg yolk, a rich source of phospholipids. Therefore, a supplement of lutein plus phospholipids was tested for effects on serum accumulation.

Methods: A 10 day supplementation with a solid-lipid particle (SLP) lutein complex or conventional lutein ester was done in apparently healthy people (both supplement types taken with fat containing meals). Plasma lutein was measured pre- and post-supplementation as well as 7 days after supplementation stopped. Changes within each supplement group were analyzed by paired t-test; group comparisons were done by unpaired t-test.

Results: The solid-lipid particle complex lutein gave much higher plasma lutein values than conventional lutein ester. The lutein complex showed superior effects based on absolute mean value after 10 days of supplementation, change in value from baseline to 10 days, and value at 7 days after supplement discontinuation.

Conclusions: A solid lipid lutein complex strongly increased plasma lutein levels compared to a conventional form.

No MeSH data available.


Related in: MedlinePlus