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Callus Formation and Mineralization after Fracture with Different Fixation Techniques: Minimally Invasive Plate Osteosynthesis versus Open Reduction Internal Fixation.

Xu H, Xue Z, Ding H, Qin H, An Z - PLoS ONE (2015)

Bottom Line: Previous study has demonstrated that MIPO technique has the advantage of less soft tissue injury compared with open reduction internal fixation (ORIF).The fracture union rate has no significant difference between two groups.As MIPO technique can effectively reduce soft tissue injury with little incision, it is considered to be a promising alternative for fracture fixation.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

ABSTRACT
Minimally invasive plate osteosynthesis(MIPO) has been considered as an alternative for fracture treatment. Previous study has demonstrated that MIPO technique has the advantage of less soft tissue injury compared with open reduction internal fixation (ORIF). However, the comparison of callus formation and mineralization between two plate osteosynthesis methods remains unknown. In this experiment, ulna fracture model was established in 42 beagle dogs. The fractures underwent reduction and internal fixation with MIPO or ORIF. Sequential fluorescent labeling and radiographs were applied to determine new callus formation and mineralization in two groups after operation. At 4, 8 and 12 weeks postoperatively, the animals were selected to be sacrificed and the ulna specimens were analyzed by Micro-CT. The sections were also treated with Masson staining for histological evaluation. More callus formation was observed in MIPO group in early stage of fracture healing. The fracture union rate has no significant difference between two groups. The results indicate that excessive soft tissue stripping may impact early callus formation. As MIPO technique can effectively reduce soft tissue injury with little incision, it is considered to be a promising alternative for fracture fixation.

No MeSH data available.


Related in: MedlinePlus

1 day, 4, 6, 10 weeks postoperative radiographs images for beagles treated with minimally invasive plate osteosynthesis (MIPO) (A-D) and open reduction internal fixation (ORIF) (E-H).
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pone.0140037.g001: 1 day, 4, 6, 10 weeks postoperative radiographs images for beagles treated with minimally invasive plate osteosynthesis (MIPO) (A-D) and open reduction internal fixation (ORIF) (E-H).

Mentions: The fracture union was evaluated by radiographic image (Fig 1). There were 7 of 21 fractures obtaining union by 4 weeks in MIPO group, while there are 8 in ORIF group. At 6 weeks postoperatively, 11 of 14 animals in Group A obtained union and all fractures healed at 10 weeks postoperatively. In contrast, 12 of 14 dogs in Group B got fracture union at 6 weeks after the surgery, and all animals healed at 10 weeks postoperatively. MIPO group had a significantly larger fracture gap than ORIF group. The mediolateral translation in MIPO group was significantly greater than in ORIF group (Table 1).


Callus Formation and Mineralization after Fracture with Different Fixation Techniques: Minimally Invasive Plate Osteosynthesis versus Open Reduction Internal Fixation.

Xu H, Xue Z, Ding H, Qin H, An Z - PLoS ONE (2015)

1 day, 4, 6, 10 weeks postoperative radiographs images for beagles treated with minimally invasive plate osteosynthesis (MIPO) (A-D) and open reduction internal fixation (ORIF) (E-H).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4596811&req=5

pone.0140037.g001: 1 day, 4, 6, 10 weeks postoperative radiographs images for beagles treated with minimally invasive plate osteosynthesis (MIPO) (A-D) and open reduction internal fixation (ORIF) (E-H).
Mentions: The fracture union was evaluated by radiographic image (Fig 1). There were 7 of 21 fractures obtaining union by 4 weeks in MIPO group, while there are 8 in ORIF group. At 6 weeks postoperatively, 11 of 14 animals in Group A obtained union and all fractures healed at 10 weeks postoperatively. In contrast, 12 of 14 dogs in Group B got fracture union at 6 weeks after the surgery, and all animals healed at 10 weeks postoperatively. MIPO group had a significantly larger fracture gap than ORIF group. The mediolateral translation in MIPO group was significantly greater than in ORIF group (Table 1).

Bottom Line: Previous study has demonstrated that MIPO technique has the advantage of less soft tissue injury compared with open reduction internal fixation (ORIF).The fracture union rate has no significant difference between two groups.As MIPO technique can effectively reduce soft tissue injury with little incision, it is considered to be a promising alternative for fracture fixation.

View Article: PubMed Central - PubMed

Affiliation: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

ABSTRACT
Minimally invasive plate osteosynthesis(MIPO) has been considered as an alternative for fracture treatment. Previous study has demonstrated that MIPO technique has the advantage of less soft tissue injury compared with open reduction internal fixation (ORIF). However, the comparison of callus formation and mineralization between two plate osteosynthesis methods remains unknown. In this experiment, ulna fracture model was established in 42 beagle dogs. The fractures underwent reduction and internal fixation with MIPO or ORIF. Sequential fluorescent labeling and radiographs were applied to determine new callus formation and mineralization in two groups after operation. At 4, 8 and 12 weeks postoperatively, the animals were selected to be sacrificed and the ulna specimens were analyzed by Micro-CT. The sections were also treated with Masson staining for histological evaluation. More callus formation was observed in MIPO group in early stage of fracture healing. The fracture union rate has no significant difference between two groups. The results indicate that excessive soft tissue stripping may impact early callus formation. As MIPO technique can effectively reduce soft tissue injury with little incision, it is considered to be a promising alternative for fracture fixation.

No MeSH data available.


Related in: MedlinePlus