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A Nation-Wide Cancer Registry-Based Study of Adenosquamous Carcinoma in Taiwan.

Lan YT, Huang KH, Liu CA, Tai LC, Chen MH, Chao Y, Li AF, Chiou SH, Shyr YM, Wu CW, Fang WL - PLoS ONE (2015)

Bottom Line: The overall survival were significantly higher for cases involving the female reproductive system, followed by the respiratory and alimentary systems (P = 0.016).ASC histology is an independent unfavorable prognostic factor compared with AC and SCC.ASC at an old age and more advanced T and N categories were found to be associated with a poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.

ABSTRACT

Background: Adenosquamous carcinoma (ASC) is a rare disease involving various organs, yet there are no large-scale population-based comparative studies on ASC among different organs.

Methods: The incidence and overall survival of ASC among various organs in cases diagnosed in Taiwan from January 1, 2003 to December 31, 2010 were calculated and compared using data from the Taiwan Cancer Registry (TCR). The various organs were classified and divided into three different systems: the female reproductive, respiratory, and alimentary systems. Survival analysis were also compared among 30,850 patients diagnosed as ASC, adenocarcinoma (AC) or squamous cell carcinoma (SCC) in organs with frequent ASC.

Results: During the study period, a total of 576 ASC cases were diagnosed in Taiwan. The most common primary system was respiratory (73.8%), followed by alimentary (16.2%) and female reproductive (10%). The overall survival were significantly higher for cases involving the female reproductive system, followed by the respiratory and alimentary systems (P = 0.016). The median overall survival were worse in males than females for cases involving the respiratory system (22.4 vs. 31.8 months, P = 0.044). Multivariate analysis showed that age ≧ 65, more advanced T and N categories were independent unfavorable prognostic factors of overall survival in ASC. ASC histology is an independent unfavorable prognostic factor compared with AC and SCC.

Conclusions: ASC at an old age and more advanced T and N categories were found to be associated with a poor prognosis.

No MeSH data available.


Related in: MedlinePlus

The age-standardized incidence rates of ASC according to different systems.
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Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4596803&req=5

pone.0139748.g001: The age-standardized incidence rates of ASC according to different systems.

Mentions: As shown in Fig 1, the age standardized incidence rates of ASC were low between year 2003 and 2005 and increased to a plateau after year 2007, which was highest in the respiratory system, followed by the alimentary system and the female reproductive system.


A Nation-Wide Cancer Registry-Based Study of Adenosquamous Carcinoma in Taiwan.

Lan YT, Huang KH, Liu CA, Tai LC, Chen MH, Chao Y, Li AF, Chiou SH, Shyr YM, Wu CW, Fang WL - PLoS ONE (2015)

The age-standardized incidence rates of ASC according to different systems.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4596803&req=5

pone.0139748.g001: The age-standardized incidence rates of ASC according to different systems.
Mentions: As shown in Fig 1, the age standardized incidence rates of ASC were low between year 2003 and 2005 and increased to a plateau after year 2007, which was highest in the respiratory system, followed by the alimentary system and the female reproductive system.

Bottom Line: The overall survival were significantly higher for cases involving the female reproductive system, followed by the respiratory and alimentary systems (P = 0.016).ASC histology is an independent unfavorable prognostic factor compared with AC and SCC.ASC at an old age and more advanced T and N categories were found to be associated with a poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan.

ABSTRACT

Background: Adenosquamous carcinoma (ASC) is a rare disease involving various organs, yet there are no large-scale population-based comparative studies on ASC among different organs.

Methods: The incidence and overall survival of ASC among various organs in cases diagnosed in Taiwan from January 1, 2003 to December 31, 2010 were calculated and compared using data from the Taiwan Cancer Registry (TCR). The various organs were classified and divided into three different systems: the female reproductive, respiratory, and alimentary systems. Survival analysis were also compared among 30,850 patients diagnosed as ASC, adenocarcinoma (AC) or squamous cell carcinoma (SCC) in organs with frequent ASC.

Results: During the study period, a total of 576 ASC cases were diagnosed in Taiwan. The most common primary system was respiratory (73.8%), followed by alimentary (16.2%) and female reproductive (10%). The overall survival were significantly higher for cases involving the female reproductive system, followed by the respiratory and alimentary systems (P = 0.016). The median overall survival were worse in males than females for cases involving the respiratory system (22.4 vs. 31.8 months, P = 0.044). Multivariate analysis showed that age ≧ 65, more advanced T and N categories were independent unfavorable prognostic factors of overall survival in ASC. ASC histology is an independent unfavorable prognostic factor compared with AC and SCC.

Conclusions: ASC at an old age and more advanced T and N categories were found to be associated with a poor prognosis.

No MeSH data available.


Related in: MedlinePlus