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EEG Source Imaging in Partial Epilepsy in Comparison with Presurgical Evaluation and Magnetoencephalography.

Park CJ, Seo JH, Kim D, Abibullaev B, Kwon H, Lee YH, Kim MY, An KM, Kim K, Kim JS, Joo EY, Hong SB - J Clin Neurol (2015)

Bottom Line: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level.The ESI results were well concordant with MSI results in 90.0% of cases.The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background and purpose: The aim of this study was to determine the usefulness of three-dimensional (3D) scalp EEG source imaging (ESI) in partial epilepsy in comparison with the results of presurgical evaluation, magnetoencephalography (MEG), and electrocorticography (ECoG).

Methods: The epilepsy syndrome of 27 partial epilepsy patients was determined by presurgical evaluations. EEG recordings were made using 70 scalp electrodes, and the 3D coordinates of the electrodes were digitized. ESI images of individual and averaged spikes were analyzed by Curry software with a boundary element method. MEG and ECoG were performed in 23 and 9 patients, respectively.

Results: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level. However, there were no spikes in the MEG recordings of three patients. The ESI results were well concordant with MSI results in 90.0% of cases. Compared to ECoG, the ESI results tended to be localized deeper than the cortex, whereas the MSI results were generally localized on the cortical surface. ESI was well concordant with ECoG in 8 of 9 (88.9%) cases, and MSI was also well concordant with ECoG in 4 of 5 (80.0%) cases. The EEG single dipoles in one patient with mesial temporal lobe epilepsy were tightly clustered with the averaged dipole when a 3 Hz high-pass filter was used.

Conclusions: The ESI results were well concordant with the results of the presurgical evaluation, MSI, and ECoG. The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

No MeSH data available.


Related in: MedlinePlus

The comparison between ECoG and EEG dipoles of patient #26. The patient had left mesial temporal lobe epilepsy. A: Intracranial EEG electrode locations were plotted on the patient's three dimensional MRI. Red circle indicates the electrode location of ictal ECoG onset, and bright blue circle indicates the location of interictal spikes frequently recorded on ECoG. B: EEG dipoles of averaged 64 spikes with different high-pass filter settings: red: 0.5 Hz, orange: 1 Hz, yellow: 2 Hz, green: 3 Hz, bright blue: 4 Hz, blue: 5 Hz, violet: 6 Hz. The circle around each dipole indicates confidence ellipsoid range. L: left, R: right.
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Figure 4: The comparison between ECoG and EEG dipoles of patient #26. The patient had left mesial temporal lobe epilepsy. A: Intracranial EEG electrode locations were plotted on the patient's three dimensional MRI. Red circle indicates the electrode location of ictal ECoG onset, and bright blue circle indicates the location of interictal spikes frequently recorded on ECoG. B: EEG dipoles of averaged 64 spikes with different high-pass filter settings: red: 0.5 Hz, orange: 1 Hz, yellow: 2 Hz, green: 3 Hz, bright blue: 4 Hz, blue: 5 Hz, violet: 6 Hz. The circle around each dipole indicates confidence ellipsoid range. L: left, R: right.

Mentions: Fig. 4 compares the ECoG findings and the EEG dipoles of patient #26 with left MTLE. The electrode location of ictal EEG onset in ECoG is indicated by a red circle (Fig. 4A), and the location of interictal spikes frequently recorded in ECoG is indicated by a bright blue circle. The ESI results for the averaged 64 spikes as obtained when using different HPF cutoffs are shown in Fig. 4B in different colors. The circle around each dipole indicates the CE range.


EEG Source Imaging in Partial Epilepsy in Comparison with Presurgical Evaluation and Magnetoencephalography.

Park CJ, Seo JH, Kim D, Abibullaev B, Kwon H, Lee YH, Kim MY, An KM, Kim K, Kim JS, Joo EY, Hong SB - J Clin Neurol (2015)

The comparison between ECoG and EEG dipoles of patient #26. The patient had left mesial temporal lobe epilepsy. A: Intracranial EEG electrode locations were plotted on the patient's three dimensional MRI. Red circle indicates the electrode location of ictal ECoG onset, and bright blue circle indicates the location of interictal spikes frequently recorded on ECoG. B: EEG dipoles of averaged 64 spikes with different high-pass filter settings: red: 0.5 Hz, orange: 1 Hz, yellow: 2 Hz, green: 3 Hz, bright blue: 4 Hz, blue: 5 Hz, violet: 6 Hz. The circle around each dipole indicates confidence ellipsoid range. L: left, R: right.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4596098&req=5

Figure 4: The comparison between ECoG and EEG dipoles of patient #26. The patient had left mesial temporal lobe epilepsy. A: Intracranial EEG electrode locations were plotted on the patient's three dimensional MRI. Red circle indicates the electrode location of ictal ECoG onset, and bright blue circle indicates the location of interictal spikes frequently recorded on ECoG. B: EEG dipoles of averaged 64 spikes with different high-pass filter settings: red: 0.5 Hz, orange: 1 Hz, yellow: 2 Hz, green: 3 Hz, bright blue: 4 Hz, blue: 5 Hz, violet: 6 Hz. The circle around each dipole indicates confidence ellipsoid range. L: left, R: right.
Mentions: Fig. 4 compares the ECoG findings and the EEG dipoles of patient #26 with left MTLE. The electrode location of ictal EEG onset in ECoG is indicated by a red circle (Fig. 4A), and the location of interictal spikes frequently recorded in ECoG is indicated by a bright blue circle. The ESI results for the averaged 64 spikes as obtained when using different HPF cutoffs are shown in Fig. 4B in different colors. The circle around each dipole indicates the CE range.

Bottom Line: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level.The ESI results were well concordant with MSI results in 90.0% of cases.The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background and purpose: The aim of this study was to determine the usefulness of three-dimensional (3D) scalp EEG source imaging (ESI) in partial epilepsy in comparison with the results of presurgical evaluation, magnetoencephalography (MEG), and electrocorticography (ECoG).

Methods: The epilepsy syndrome of 27 partial epilepsy patients was determined by presurgical evaluations. EEG recordings were made using 70 scalp electrodes, and the 3D coordinates of the electrodes were digitized. ESI images of individual and averaged spikes were analyzed by Curry software with a boundary element method. MEG and ECoG were performed in 23 and 9 patients, respectively.

Results: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level. However, there were no spikes in the MEG recordings of three patients. The ESI results were well concordant with MSI results in 90.0% of cases. Compared to ECoG, the ESI results tended to be localized deeper than the cortex, whereas the MSI results were generally localized on the cortical surface. ESI was well concordant with ECoG in 8 of 9 (88.9%) cases, and MSI was also well concordant with ECoG in 4 of 5 (80.0%) cases. The EEG single dipoles in one patient with mesial temporal lobe epilepsy were tightly clustered with the averaged dipole when a 3 Hz high-pass filter was used.

Conclusions: The ESI results were well concordant with the results of the presurgical evaluation, MSI, and ECoG. The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

No MeSH data available.


Related in: MedlinePlus