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EEG Source Imaging in Partial Epilepsy in Comparison with Presurgical Evaluation and Magnetoencephalography.

Park CJ, Seo JH, Kim D, Abibullaev B, Kwon H, Lee YH, Kim MY, An KM, Kim K, Kim JS, Joo EY, Hong SB - J Clin Neurol (2015)

Bottom Line: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level.The ESI results were well concordant with MSI results in 90.0% of cases.The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background and purpose: The aim of this study was to determine the usefulness of three-dimensional (3D) scalp EEG source imaging (ESI) in partial epilepsy in comparison with the results of presurgical evaluation, magnetoencephalography (MEG), and electrocorticography (ECoG).

Methods: The epilepsy syndrome of 27 partial epilepsy patients was determined by presurgical evaluations. EEG recordings were made using 70 scalp electrodes, and the 3D coordinates of the electrodes were digitized. ESI images of individual and averaged spikes were analyzed by Curry software with a boundary element method. MEG and ECoG were performed in 23 and 9 patients, respectively.

Results: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level. However, there were no spikes in the MEG recordings of three patients. The ESI results were well concordant with MSI results in 90.0% of cases. Compared to ECoG, the ESI results tended to be localized deeper than the cortex, whereas the MSI results were generally localized on the cortical surface. ESI was well concordant with ECoG in 8 of 9 (88.9%) cases, and MSI was also well concordant with ECoG in 4 of 5 (80.0%) cases. The EEG single dipoles in one patient with mesial temporal lobe epilepsy were tightly clustered with the averaged dipole when a 3 Hz high-pass filter was used.

Conclusions: The ESI results were well concordant with the results of the presurgical evaluation, MSI, and ECoG. The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

No MeSH data available.


Related in: MedlinePlus

EEG and MEG dipole source analysis of patient #4 who had right frontocentral lobe epilepsy. A: EEG dipoles [high-pass filter (HPF)=3 Hz, goodness of fit (GOF) levels ≥70%] were localized in right frontal lobe. B: MEG dipoles (HPF=3 Hz, GOF levels ≥70%) were localized in right frontal and parietal regions. C: FDG-PET showed hypometabolism in right frontoparietal cortex. D: SISCOM showed ictal hyperperfusion in the right dorsolateral and medial frontal cortices. L: left, R: right.
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Figure 2: EEG and MEG dipole source analysis of patient #4 who had right frontocentral lobe epilepsy. A: EEG dipoles [high-pass filter (HPF)=3 Hz, goodness of fit (GOF) levels ≥70%] were localized in right frontal lobe. B: MEG dipoles (HPF=3 Hz, GOF levels ≥70%) were localized in right frontal and parietal regions. C: FDG-PET showed hypometabolism in right frontoparietal cortex. D: SISCOM showed ictal hyperperfusion in the right dorsolateral and medial frontal cortices. L: left, R: right.

Mentions: Brain MRI revealed no lesion in eight patients (#3, 4, 11, 13, 17, 19, 21, and 25). When the ESI and MSI results were compared with the location of the epileptic focus determined by the presurgical evaluation, the locations of all EEG and MEG dipoles were well concordant with those epileptic foci at the lobar level. The comparison between the ESI and MSI results revealed differences at the sublobar level. In patient #3, the ESI and MSI results were similar at the sublobar level. However, the EEG and MEG dipoles of the other patients differed slightly at the sublobar level. The EEG dipoles were located more anteriorly than the MEG dipoles in patient #4 (Fig. 2). In patient #11 and 13, EEG dipoles were located in the left anterior temporal lobe whereas the MEG dipoles were seen throughout the anterior, middle, and posterior temporal regions.


EEG Source Imaging in Partial Epilepsy in Comparison with Presurgical Evaluation and Magnetoencephalography.

Park CJ, Seo JH, Kim D, Abibullaev B, Kwon H, Lee YH, Kim MY, An KM, Kim K, Kim JS, Joo EY, Hong SB - J Clin Neurol (2015)

EEG and MEG dipole source analysis of patient #4 who had right frontocentral lobe epilepsy. A: EEG dipoles [high-pass filter (HPF)=3 Hz, goodness of fit (GOF) levels ≥70%] were localized in right frontal lobe. B: MEG dipoles (HPF=3 Hz, GOF levels ≥70%) were localized in right frontal and parietal regions. C: FDG-PET showed hypometabolism in right frontoparietal cortex. D: SISCOM showed ictal hyperperfusion in the right dorsolateral and medial frontal cortices. L: left, R: right.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4596098&req=5

Figure 2: EEG and MEG dipole source analysis of patient #4 who had right frontocentral lobe epilepsy. A: EEG dipoles [high-pass filter (HPF)=3 Hz, goodness of fit (GOF) levels ≥70%] were localized in right frontal lobe. B: MEG dipoles (HPF=3 Hz, GOF levels ≥70%) were localized in right frontal and parietal regions. C: FDG-PET showed hypometabolism in right frontoparietal cortex. D: SISCOM showed ictal hyperperfusion in the right dorsolateral and medial frontal cortices. L: left, R: right.
Mentions: Brain MRI revealed no lesion in eight patients (#3, 4, 11, 13, 17, 19, 21, and 25). When the ESI and MSI results were compared with the location of the epileptic focus determined by the presurgical evaluation, the locations of all EEG and MEG dipoles were well concordant with those epileptic foci at the lobar level. The comparison between the ESI and MSI results revealed differences at the sublobar level. In patient #3, the ESI and MSI results were similar at the sublobar level. However, the EEG and MEG dipoles of the other patients differed slightly at the sublobar level. The EEG dipoles were located more anteriorly than the MEG dipoles in patient #4 (Fig. 2). In patient #11 and 13, EEG dipoles were located in the left anterior temporal lobe whereas the MEG dipoles were seen throughout the anterior, middle, and posterior temporal regions.

Bottom Line: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level.The ESI results were well concordant with MSI results in 90.0% of cases.The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT

Background and purpose: The aim of this study was to determine the usefulness of three-dimensional (3D) scalp EEG source imaging (ESI) in partial epilepsy in comparison with the results of presurgical evaluation, magnetoencephalography (MEG), and electrocorticography (ECoG).

Methods: The epilepsy syndrome of 27 partial epilepsy patients was determined by presurgical evaluations. EEG recordings were made using 70 scalp electrodes, and the 3D coordinates of the electrodes were digitized. ESI images of individual and averaged spikes were analyzed by Curry software with a boundary element method. MEG and ECoG were performed in 23 and 9 patients, respectively.

Results: ESI and MEG source imaging (MSI) results were well concordant with the results of presurgical evaluations (in 96.3% and 100% cases for ESI and MSI, respectively) at the lobar level. However, there were no spikes in the MEG recordings of three patients. The ESI results were well concordant with MSI results in 90.0% of cases. Compared to ECoG, the ESI results tended to be localized deeper than the cortex, whereas the MSI results were generally localized on the cortical surface. ESI was well concordant with ECoG in 8 of 9 (88.9%) cases, and MSI was also well concordant with ECoG in 4 of 5 (80.0%) cases. The EEG single dipoles in one patient with mesial temporal lobe epilepsy were tightly clustered with the averaged dipole when a 3 Hz high-pass filter was used.

Conclusions: The ESI results were well concordant with the results of the presurgical evaluation, MSI, and ECoG. The ESI analysis was found to be useful for localizing the seizure focus and is recommended for the presurgical evaluation of intractable epilepsy patients.

No MeSH data available.


Related in: MedlinePlus