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Neopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers.

Pingle SK, Thakkar LR, Jawade AA, Tumane RG, Jain RK, Soni PN - Indian J Occup Environ Med (2015 May-Aug)

Bottom Line: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level.Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups.The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, National Institute of Miners' Health, Nagpur, Maharashtra, India.

ABSTRACT

Introduction: Bauxite ore is a major source of aluminum (Al) which contains approximately 35-60% Al by weight. Occupational and environmental bauxite dust exposure may cause toxicity by interaction with human biological systems resulting in oxidative stress (OS) and cell death. A neopterin derivative as an antioxidant is able to modulate cytotoxicity by the induction of OS.

Materials and methods: A total of 273 subjects were selected for blood collection from three different major Al producing bauxite mines and were categorized into three groups as experimental (Exp) (n = 150), experimental controls (ExC) (n = 73) and control (Con) (n = 50). Whole blood and serum samples were used for measurement of Al, neopterin, urea and creatinine values. Statistical analysis was performed using R-2.15.1 programming language.

Results and discussion: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level. Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups. Significantly positive correlation (P < 0.0001) was observed between neopterin and creatinine. It was also observed that neopterin level increases as the duration of exposure increases.

Conclusion: On the basis of findings it was concluded that exposure to bauxite dust (even at low levels of Al) changes biochemical profile leading to high levels of serum neopterin. Levels of serum neopterin in workers exposed to bauxite dust were probably examined for the 1(st) time in India. The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

No MeSH data available.


Related in: MedlinePlus

Bar charts with error bars showing mean duration of exposure and neopterin
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Figure 2: Bar charts with error bars showing mean duration of exposure and neopterin

Mentions: Figure 2 shows the bar plots for the mean duration of exposure and the mean neopterin level in experimental control and experimental groups. The mean neopterin level was higher in the experimental group as compared to experimental control group, and the difference was statistically significant with P value of 0.0003 (P < 0.05). The mean neopterin level in Experimental group was 1.12 times higher than the experimental group although the mean duration of exposure was very close in two groups. This again suggests the possibility of some hidden factors influencing the neopterin levels in the experimental group.


Neopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers.

Pingle SK, Thakkar LR, Jawade AA, Tumane RG, Jain RK, Soni PN - Indian J Occup Environ Med (2015 May-Aug)

Bar charts with error bars showing mean duration of exposure and neopterin
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4596068&req=5

Figure 2: Bar charts with error bars showing mean duration of exposure and neopterin
Mentions: Figure 2 shows the bar plots for the mean duration of exposure and the mean neopterin level in experimental control and experimental groups. The mean neopterin level was higher in the experimental group as compared to experimental control group, and the difference was statistically significant with P value of 0.0003 (P < 0.05). The mean neopterin level in Experimental group was 1.12 times higher than the experimental group although the mean duration of exposure was very close in two groups. This again suggests the possibility of some hidden factors influencing the neopterin levels in the experimental group.

Bottom Line: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level.Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups.The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, National Institute of Miners' Health, Nagpur, Maharashtra, India.

ABSTRACT

Introduction: Bauxite ore is a major source of aluminum (Al) which contains approximately 35-60% Al by weight. Occupational and environmental bauxite dust exposure may cause toxicity by interaction with human biological systems resulting in oxidative stress (OS) and cell death. A neopterin derivative as an antioxidant is able to modulate cytotoxicity by the induction of OS.

Materials and methods: A total of 273 subjects were selected for blood collection from three different major Al producing bauxite mines and were categorized into three groups as experimental (Exp) (n = 150), experimental controls (ExC) (n = 73) and control (Con) (n = 50). Whole blood and serum samples were used for measurement of Al, neopterin, urea and creatinine values. Statistical analysis was performed using R-2.15.1 programming language.

Results and discussion: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level. Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups. Significantly positive correlation (P < 0.0001) was observed between neopterin and creatinine. It was also observed that neopterin level increases as the duration of exposure increases.

Conclusion: On the basis of findings it was concluded that exposure to bauxite dust (even at low levels of Al) changes biochemical profile leading to high levels of serum neopterin. Levels of serum neopterin in workers exposed to bauxite dust were probably examined for the 1(st) time in India. The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

No MeSH data available.


Related in: MedlinePlus