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Neopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers.

Pingle SK, Thakkar LR, Jawade AA, Tumane RG, Jain RK, Soni PN - Indian J Occup Environ Med (2015 May-Aug)

Bottom Line: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level.Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups.The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, National Institute of Miners' Health, Nagpur, Maharashtra, India.

ABSTRACT

Introduction: Bauxite ore is a major source of aluminum (Al) which contains approximately 35-60% Al by weight. Occupational and environmental bauxite dust exposure may cause toxicity by interaction with human biological systems resulting in oxidative stress (OS) and cell death. A neopterin derivative as an antioxidant is able to modulate cytotoxicity by the induction of OS.

Materials and methods: A total of 273 subjects were selected for blood collection from three different major Al producing bauxite mines and were categorized into three groups as experimental (Exp) (n = 150), experimental controls (ExC) (n = 73) and control (Con) (n = 50). Whole blood and serum samples were used for measurement of Al, neopterin, urea and creatinine values. Statistical analysis was performed using R-2.15.1 programming language.

Results and discussion: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level. Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups. Significantly positive correlation (P < 0.0001) was observed between neopterin and creatinine. It was also observed that neopterin level increases as the duration of exposure increases.

Conclusion: On the basis of findings it was concluded that exposure to bauxite dust (even at low levels of Al) changes biochemical profile leading to high levels of serum neopterin. Levels of serum neopterin in workers exposed to bauxite dust were probably examined for the 1(st) time in India. The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

No MeSH data available.


Related in: MedlinePlus

Correlation between neopterin and creatinine
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Figure 1: Correlation between neopterin and creatinine

Mentions: Figure 1 provides the relationship between neopterin and creatinine levels considering subjects from all three groups. It is evident from the scatter that as neopterin level increases, the creatinine level was also found on a higher side, indicating a positive correlation between the two parameters. Pearson's correlation coefficient for the two parameters was 0.59 with a P < 0.0001 indicating significant positive relationship between the two.


Neopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers.

Pingle SK, Thakkar LR, Jawade AA, Tumane RG, Jain RK, Soni PN - Indian J Occup Environ Med (2015 May-Aug)

Correlation between neopterin and creatinine
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4596068&req=5

Figure 1: Correlation between neopterin and creatinine
Mentions: Figure 1 provides the relationship between neopterin and creatinine levels considering subjects from all three groups. It is evident from the scatter that as neopterin level increases, the creatinine level was also found on a higher side, indicating a positive correlation between the two parameters. Pearson's correlation coefficient for the two parameters was 0.59 with a P < 0.0001 indicating significant positive relationship between the two.

Bottom Line: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level.Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups.The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

View Article: PubMed Central - PubMed

Affiliation: Department of Biochemistry, National Institute of Miners' Health, Nagpur, Maharashtra, India.

ABSTRACT

Introduction: Bauxite ore is a major source of aluminum (Al) which contains approximately 35-60% Al by weight. Occupational and environmental bauxite dust exposure may cause toxicity by interaction with human biological systems resulting in oxidative stress (OS) and cell death. A neopterin derivative as an antioxidant is able to modulate cytotoxicity by the induction of OS.

Materials and methods: A total of 273 subjects were selected for blood collection from three different major Al producing bauxite mines and were categorized into three groups as experimental (Exp) (n = 150), experimental controls (ExC) (n = 73) and control (Con) (n = 50). Whole blood and serum samples were used for measurement of Al, neopterin, urea and creatinine values. Statistical analysis was performed using R-2.15.1 programming language.

Results and discussion: The result showed that age, body mass index and the behavioral habits, that is, smoking, tobacco and alcohol consumption have possible effects on neopterin level. Serum neopterin levels were found to be significantly higher (P <0.0001) in the experimental group as compared to other groups. Significantly positive correlation (P < 0.0001) was observed between neopterin and creatinine. It was also observed that neopterin level increases as the duration of exposure increases.

Conclusion: On the basis of findings it was concluded that exposure to bauxite dust (even at low levels of Al) changes biochemical profile leading to high levels of serum neopterin. Levels of serum neopterin in workers exposed to bauxite dust were probably examined for the 1(st) time in India. The outcome of this study suggested that serum neopterin may be used as potential biomarker for early detection of health risks associated with bauxite dust exposed population.

No MeSH data available.


Related in: MedlinePlus