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Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition(1,2,3).

Becker S, Gandhi W, Kwan S, Ahmed AK, Schweinhardt P - eNeuro (2015)

Bottom Line: We tested this hypothesis in a psychophysical experiment in healthy human subjects, by assessing potential pain-inhibitory effects of pain relief "won" in a wheel of fortune game compared with pain relief without winning, exploiting the fact that the mere chance of winning induces a motivated state.Further, the higher participants scored on the personality trait novelty seeking, the more pain inhibition was induced.Consequently, such pain relief might be used to improve behavioral pain therapy, inducing a positive, perhaps self-amplifying feedback loop of reduced pain and improved functionality.

View Article: PubMed Central - HTML - PubMed

Affiliation: Alan Edwards Centre for Research on Pain, McGill University , Montreal, Quebec H3A 0C7, Canada ; Faculty of Dentistry, McGill University , Montreal, Quebec H3A 0C7, Canada ; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University , 68159 Mannheim, Germany.

ABSTRACT
When in pain, pain relief is much sought after, particularly for individuals with chronic pain. In analogy to augmentation of the hedonic experience ("liking") of a reward by the motivation to obtain a reward ("wanting"), the seeking of pain relief in a motivated state might increase the experience of pain relief when obtained. We tested this hypothesis in a psychophysical experiment in healthy human subjects, by assessing potential pain-inhibitory effects of pain relief "won" in a wheel of fortune game compared with pain relief without winning, exploiting the fact that the mere chance of winning induces a motivated state. The results show pain-inhibitory effects of pain relief obtained by winning in behaviorally assessed pain perception and ratings of pain intensity. Further, the higher participants scored on the personality trait novelty seeking, the more pain inhibition was induced. These results provide evidence that pain relief, when obtained in a motivated state, engages endogenous pain-inhibitory systems beyond the pain reduction that underlies the relief in the first place. Consequently, such pain relief might be used to improve behavioral pain therapy, inducing a positive, perhaps self-amplifying feedback loop of reduced pain and improved functionality.

No MeSH data available.


Related in: MedlinePlus

Correlation of participants’ scores on the novelty-seeking subscale of the TCI and pain modulation by pain relief obtained by winning, which was calculated as the difference between intensity ratings in the test minus the control trials of the pain relief outcome.
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Figure 4: Correlation of participants’ scores on the novelty-seeking subscale of the TCI and pain modulation by pain relief obtained by winning, which was calculated as the difference between intensity ratings in the test minus the control trials of the pain relief outcome.

Mentions: Participants showed more endogenous pain inhibition by pain relief obtained by winning the more novelty seeking they were: the amount of pain inhibition by pain relief that was won in the test compared with the control trials correlated negatively with novelty seeking assessed with the TCI questionnaire (Fig. 4; r = −0.54, p = 0.005ai). Because pain inhibition by pain relief obtained by winning was calculated as the difference between VAS ratings of perceived intensity in the test and control trials, negative values indicate successful pain inhibition. Novelty seeking was specifically related to induced pain inhibition obtained by winning pain relief and not to the level of the perceived pain in either the test or the control trials, which was demonstrated by computing separate correlations of the pain ratings with the novelty-seeking scores in the test trials (r = −0.15, p = 0.48aj) and control trials (r = 0.08, p = 0.72ak). No correlations were found with harm avoidance and reward dependence.


Doubling Your Payoff: Winning Pain Relief Engages Endogenous Pain Inhibition(1,2,3).

Becker S, Gandhi W, Kwan S, Ahmed AK, Schweinhardt P - eNeuro (2015)

Correlation of participants’ scores on the novelty-seeking subscale of the TCI and pain modulation by pain relief obtained by winning, which was calculated as the difference between intensity ratings in the test minus the control trials of the pain relief outcome.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4596013&req=5

Figure 4: Correlation of participants’ scores on the novelty-seeking subscale of the TCI and pain modulation by pain relief obtained by winning, which was calculated as the difference between intensity ratings in the test minus the control trials of the pain relief outcome.
Mentions: Participants showed more endogenous pain inhibition by pain relief obtained by winning the more novelty seeking they were: the amount of pain inhibition by pain relief that was won in the test compared with the control trials correlated negatively with novelty seeking assessed with the TCI questionnaire (Fig. 4; r = −0.54, p = 0.005ai). Because pain inhibition by pain relief obtained by winning was calculated as the difference between VAS ratings of perceived intensity in the test and control trials, negative values indicate successful pain inhibition. Novelty seeking was specifically related to induced pain inhibition obtained by winning pain relief and not to the level of the perceived pain in either the test or the control trials, which was demonstrated by computing separate correlations of the pain ratings with the novelty-seeking scores in the test trials (r = −0.15, p = 0.48aj) and control trials (r = 0.08, p = 0.72ak). No correlations were found with harm avoidance and reward dependence.

Bottom Line: We tested this hypothesis in a psychophysical experiment in healthy human subjects, by assessing potential pain-inhibitory effects of pain relief "won" in a wheel of fortune game compared with pain relief without winning, exploiting the fact that the mere chance of winning induces a motivated state.Further, the higher participants scored on the personality trait novelty seeking, the more pain inhibition was induced.Consequently, such pain relief might be used to improve behavioral pain therapy, inducing a positive, perhaps self-amplifying feedback loop of reduced pain and improved functionality.

View Article: PubMed Central - HTML - PubMed

Affiliation: Alan Edwards Centre for Research on Pain, McGill University , Montreal, Quebec H3A 0C7, Canada ; Faculty of Dentistry, McGill University , Montreal, Quebec H3A 0C7, Canada ; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University , 68159 Mannheim, Germany.

ABSTRACT
When in pain, pain relief is much sought after, particularly for individuals with chronic pain. In analogy to augmentation of the hedonic experience ("liking") of a reward by the motivation to obtain a reward ("wanting"), the seeking of pain relief in a motivated state might increase the experience of pain relief when obtained. We tested this hypothesis in a psychophysical experiment in healthy human subjects, by assessing potential pain-inhibitory effects of pain relief "won" in a wheel of fortune game compared with pain relief without winning, exploiting the fact that the mere chance of winning induces a motivated state. The results show pain-inhibitory effects of pain relief obtained by winning in behaviorally assessed pain perception and ratings of pain intensity. Further, the higher participants scored on the personality trait novelty seeking, the more pain inhibition was induced. These results provide evidence that pain relief, when obtained in a motivated state, engages endogenous pain-inhibitory systems beyond the pain reduction that underlies the relief in the first place. Consequently, such pain relief might be used to improve behavioral pain therapy, inducing a positive, perhaps self-amplifying feedback loop of reduced pain and improved functionality.

No MeSH data available.


Related in: MedlinePlus