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Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus

Release profile of lornoxicam from coated pectin alginate beads.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig9: Release profile of lornoxicam from coated pectin alginate beads.

Mentions: The uncoated formulation P2, P3, and P5 gave burst release in 2 hrs 87.11%, 77.16%, and 74.87% after the swelling of beads (Figure 8). In the case of enteric-coated formulation P1 and P4 formulation depicted 6 hr lag time and P3, P4, and P5 formulation show lag time 5 hr because of lesser concentration of sodium alginate but the formulation P6 and P7 demonstrated 7 hrs to 8 hrs lag time due to dual cross-linking with AlCl3+ (Figure 9). In case of dual cross-linking rigid gel structure is formed which reduce the diffusion of drug from beads and increase the lag time of formulation.


Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

Release profile of lornoxicam from coated pectin alginate beads.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4595973&req=5

fig9: Release profile of lornoxicam from coated pectin alginate beads.
Mentions: The uncoated formulation P2, P3, and P5 gave burst release in 2 hrs 87.11%, 77.16%, and 74.87% after the swelling of beads (Figure 8). In the case of enteric-coated formulation P1 and P4 formulation depicted 6 hr lag time and P3, P4, and P5 formulation show lag time 5 hr because of lesser concentration of sodium alginate but the formulation P6 and P7 demonstrated 7 hrs to 8 hrs lag time due to dual cross-linking with AlCl3+ (Figure 9). In case of dual cross-linking rigid gel structure is formed which reduce the diffusion of drug from beads and increase the lag time of formulation.

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus