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Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus

% swelling of single ((a) and (b) in 6.8 pH and (c) and (d) in 1.2 pH) and dual ((e) and (f) in 6.8 pH and (g) and (h) in 1.2 pH) cross-linked beads before ((a), (c), (e), and (g)) and after 2 hours ((b), (d), (f), and (h)).
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fig5: % swelling of single ((a) and (b) in 6.8 pH and (c) and (d) in 1.2 pH) and dual ((e) and (f) in 6.8 pH and (g) and (h) in 1.2 pH) cross-linked beads before ((a), (c), (e), and (g)) and after 2 hours ((b), (d), (f), and (h)).

Mentions: Swelling property was mostly affected by the concentration of sodium alginate, pectin, and cross-linking of beads. As the concentration of sodium alginate increases the swelling capacity of beads increases considerably while the swelling capacity is rendered by cross-linking (Figure 5). Formulation P1, P4 and P6, P7 have same concentration of sodium alginate but P1 and P4 show higher swelling ability compared to P6 and P7 due to the cross-linking. It is observed that the dual cross-linking beads have lower degree of swelling ability than single cross-linked beads. Also, as the concentration of sodium alginate 450 mg in formulation P4 reduces to 250 mg in P5, the percentage swelling get reduced from 293.8 ± 20.5 to 114.4 ± 22.6 (Table 3). Swelling ability of beads was observed lesser in pH 1.2 compared to pH 6.8.


Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

% swelling of single ((a) and (b) in 6.8 pH and (c) and (d) in 1.2 pH) and dual ((e) and (f) in 6.8 pH and (g) and (h) in 1.2 pH) cross-linked beads before ((a), (c), (e), and (g)) and after 2 hours ((b), (d), (f), and (h)).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4595973&req=5

fig5: % swelling of single ((a) and (b) in 6.8 pH and (c) and (d) in 1.2 pH) and dual ((e) and (f) in 6.8 pH and (g) and (h) in 1.2 pH) cross-linked beads before ((a), (c), (e), and (g)) and after 2 hours ((b), (d), (f), and (h)).
Mentions: Swelling property was mostly affected by the concentration of sodium alginate, pectin, and cross-linking of beads. As the concentration of sodium alginate increases the swelling capacity of beads increases considerably while the swelling capacity is rendered by cross-linking (Figure 5). Formulation P1, P4 and P6, P7 have same concentration of sodium alginate but P1 and P4 show higher swelling ability compared to P6 and P7 due to the cross-linking. It is observed that the dual cross-linking beads have lower degree of swelling ability than single cross-linked beads. Also, as the concentration of sodium alginate 450 mg in formulation P4 reduces to 250 mg in P5, the percentage swelling get reduced from 293.8 ± 20.5 to 114.4 ± 22.6 (Table 3). Swelling ability of beads was observed lesser in pH 1.2 compared to pH 6.8.

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus