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Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus

Effect of cross-linking time on release of lornoxicam from pectin alginate beads.
© Copyright Policy - open-access
Related In: Results  -  Collection


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fig4: Effect of cross-linking time on release of lornoxicam from pectin alginate beads.

Mentions: Entrapment efficiency and production yield increase by increasing the cross-linking time (Figure 4). Longer the cross-linking time 10–20 min amount of lornoxicam released from pectin-alginate, beads were reduced and dual cross-linked beads which have cross-linking time 10 min show more sustained release of drug from the pectin alginate beads than single cross-linked beads which have 10 min cross-linking time. Formulation of dual cross-linked beads overcomes the burst release from the formulation. The average size of dual cross-linked beads is found to be more than single cross-linked beads formulation. It suggests that trivalent ion has better cross-linking than divalent ion.


Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

Effect of cross-linking time on release of lornoxicam from pectin alginate beads.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4595973&req=5

fig4: Effect of cross-linking time on release of lornoxicam from pectin alginate beads.
Mentions: Entrapment efficiency and production yield increase by increasing the cross-linking time (Figure 4). Longer the cross-linking time 10–20 min amount of lornoxicam released from pectin-alginate, beads were reduced and dual cross-linked beads which have cross-linking time 10 min show more sustained release of drug from the pectin alginate beads than single cross-linked beads which have 10 min cross-linking time. Formulation of dual cross-linked beads overcomes the burst release from the formulation. The average size of dual cross-linked beads is found to be more than single cross-linked beads formulation. It suggests that trivalent ion has better cross-linking than divalent ion.

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus