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Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus

Graphical representation of lornoxicam solubility study at different pH ranges at room temperature.
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Related In: Results  -  Collection


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fig1: Graphical representation of lornoxicam solubility study at different pH ranges at room temperature.

Mentions: Solubility of lornoxicam increased substantially with an increase in the pH of media (Figure 1 and Table 2). It was found to be much higher in alkaline pH compared to neutral and acidic one. The solubility was found to be 0.049 mg/mL, 0.082 mg/mL, 0.156 mg/mL, 8.96 mg/mL, and 9.76 mg/mL in media with pH 1.2, pH 6.8, pH 7.4, pH 12, and pH 13, respectively. Lornoxicam showed the maximum solubility in pH 13 as compared to the other pH (Table 2), it is required to find the actual concentration of lornoxicam present in the formulated dual cross-linked beads.


Development and Evaluation of Dual Cross-Linked Pulsatile Beads for Chronotherapy of Rheumatoid Arthritis.

Bansal AK, Pande V - J Pharm (Cairo) (2012)

Graphical representation of lornoxicam solubility study at different pH ranges at room temperature.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4595973&req=5

fig1: Graphical representation of lornoxicam solubility study at different pH ranges at room temperature.
Mentions: Solubility of lornoxicam increased substantially with an increase in the pH of media (Figure 1 and Table 2). It was found to be much higher in alkaline pH compared to neutral and acidic one. The solubility was found to be 0.049 mg/mL, 0.082 mg/mL, 0.156 mg/mL, 8.96 mg/mL, and 9.76 mg/mL in media with pH 1.2, pH 6.8, pH 7.4, pH 12, and pH 13, respectively. Lornoxicam showed the maximum solubility in pH 13 as compared to the other pH (Table 2), it is required to find the actual concentration of lornoxicam present in the formulated dual cross-linked beads.

Bottom Line: Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution.The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time.In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads.

View Article: PubMed Central - PubMed

Affiliation: Department of Pharmaceutics, H.R. Patel Institute of Pharmaceutical Education and Research, Dhule, Shirpur 425405, Maharashtra, India.

ABSTRACT
In the present investigation, pulsatile release beads were prepared by ionic gelation technique. Lornoxicam dual cross-linked beads were prepared by dropping dispersed phase of lornoxicam, pectin, and sodium alginate into the dispersion phase of different concentrations of calcium chloride solution followed by aluminium chloride solution. The formulated beads were further coated by Eudragit L & S 100 in the ratio 1 : 2 w/w in order to achieve desired lag time. In vitro release study showed lag time of 5-8 h before release of lornoxicam from the formulated beads. Thus, formulated dual cross-linked beads when administered at bed time may release lornoxicam when needed most for chronotherapeutics of early morning rheumatoid arthritis attacks in chronic patients.

No MeSH data available.


Related in: MedlinePlus