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Some Pharmacodynamic Aspects of Cefepime.

Elsayed MG, Elkomy AA, Elbadawy M - J Pharm (Cairo) (2012)

Bottom Line: Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained.Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip.Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Department, Faculty of Veterinary Medicine, Benha University, P.O. Box 13736, Moshtohor, Toukh, Elqaliobiya, Egypt.

ABSTRACT
Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of cefepime on isolated rat's uterine muscle were different according to stage of sex cycle. Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip. Concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of the isolated frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2%. Cefepime completely blocked the neuromuscular transmission of frog's rectus abdominis muscle (40 μg/mL bath) and rat's phrenic nerve hemidiaphragm preparation (200 μg/mL bath). This blockade was reversed by acetylcholine and neostigmine. Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles. There were no changes in blood pressure and rate of respiration in anaesthetized dog after cefepime injection. These findings indicate that cefepime has a low potential to produce adverse reactions at therapeutic doses.

No MeSH data available.


Related in: MedlinePlus

Site of action of cefepime (Cef.) on isolated rat's phrenic nerve hemidiaphragm.
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fig8: Site of action of cefepime (Cef.) on isolated rat's phrenic nerve hemidiaphragm.

Mentions: Cefepime at concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2% (Figure 6). Concentrations of 20 μg/mL bath caused marked decrease in the contracture of frog's rectus abdominis muscles while complete blockade was produced in the presence of 40 μg/mL bath of cefepime (Figure 7). The concentrations of 80 μg/mL bath produced marked inhibition in the force of rat's phrenic nerve hemidiaphragm which was reversed by 2.5 μg acetylcholine/mL bath (Figure 8(a)) or 25 μg neostigmine/mL bath (Figure 8(b)). This indicated that cefepime might act directly to induce neuromuscular blockade.


Some Pharmacodynamic Aspects of Cefepime.

Elsayed MG, Elkomy AA, Elbadawy M - J Pharm (Cairo) (2012)

Site of action of cefepime (Cef.) on isolated rat's phrenic nerve hemidiaphragm.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4595966&req=5

fig8: Site of action of cefepime (Cef.) on isolated rat's phrenic nerve hemidiaphragm.
Mentions: Cefepime at concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2% (Figure 6). Concentrations of 20 μg/mL bath caused marked decrease in the contracture of frog's rectus abdominis muscles while complete blockade was produced in the presence of 40 μg/mL bath of cefepime (Figure 7). The concentrations of 80 μg/mL bath produced marked inhibition in the force of rat's phrenic nerve hemidiaphragm which was reversed by 2.5 μg acetylcholine/mL bath (Figure 8(a)) or 25 μg neostigmine/mL bath (Figure 8(b)). This indicated that cefepime might act directly to induce neuromuscular blockade.

Bottom Line: Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained.Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip.Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Department, Faculty of Veterinary Medicine, Benha University, P.O. Box 13736, Moshtohor, Toukh, Elqaliobiya, Egypt.

ABSTRACT
Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of cefepime on isolated rat's uterine muscle were different according to stage of sex cycle. Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip. Concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of the isolated frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2%. Cefepime completely blocked the neuromuscular transmission of frog's rectus abdominis muscle (40 μg/mL bath) and rat's phrenic nerve hemidiaphragm preparation (200 μg/mL bath). This blockade was reversed by acetylcholine and neostigmine. Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles. There were no changes in blood pressure and rate of respiration in anaesthetized dog after cefepime injection. These findings indicate that cefepime has a low potential to produce adverse reactions at therapeutic doses.

No MeSH data available.


Related in: MedlinePlus