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Some Pharmacodynamic Aspects of Cefepime.

Elsayed MG, Elkomy AA, Elbadawy M - J Pharm (Cairo) (2012)

Bottom Line: Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained.Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip.Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Department, Faculty of Veterinary Medicine, Benha University, P.O. Box 13736, Moshtohor, Toukh, Elqaliobiya, Egypt.

ABSTRACT
Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of cefepime on isolated rat's uterine muscle were different according to stage of sex cycle. Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip. Concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of the isolated frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2%. Cefepime completely blocked the neuromuscular transmission of frog's rectus abdominis muscle (40 μg/mL bath) and rat's phrenic nerve hemidiaphragm preparation (200 μg/mL bath). This blockade was reversed by acetylcholine and neostigmine. Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles. There were no changes in blood pressure and rate of respiration in anaesthetized dog after cefepime injection. These findings indicate that cefepime has a low potential to produce adverse reactions at therapeutic doses.

No MeSH data available.


Related in: MedlinePlus

Site of action of cefepime (Cef.) on isolated rat's uterus during estrus stage.
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fig3: Site of action of cefepime (Cef.) on isolated rat's uterus during estrus stage.

Mentions: The effect of cefepime on isolated guinea pig's ileum, rabbit's duodenum, rat's colon, and rat's fundic strip and uterine motility of female rats at various stages of sex cycle have been recorded and presented in Table 1. Action of cefepime on the rabbit duodenal motility is shown in Figure 1. The rat's fundic strip was depressed by cefepime in a dose-dependent manner and histamine was not able to produce its stimulant effect in presence of cefepime (Figure 2) so cefepime might appear to have an antihistaminic-like effect. Cefepime stimulated the uterine motility during estrus and nonestrus stages and depressed it during early and late pregnancy and these findings might be attributed to the direct effect of cefepime (Figures 3(a) and 3(b) and Figures 4(a) and 4(b)). Cefepime had no effect on the resting tonus of the isolated guinea pig's tracheal chain but histamine (60 μg/mL bath) was not able to produce its contractile effect in the presence of cefepime (400 μg/mL bath) as shown in Figure 5. This indicated that cefepime might have an antihistaminic like effect on this tissue.


Some Pharmacodynamic Aspects of Cefepime.

Elsayed MG, Elkomy AA, Elbadawy M - J Pharm (Cairo) (2012)

Site of action of cefepime (Cef.) on isolated rat's uterus during estrus stage.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4595966&req=5

fig3: Site of action of cefepime (Cef.) on isolated rat's uterus during estrus stage.
Mentions: The effect of cefepime on isolated guinea pig's ileum, rabbit's duodenum, rat's colon, and rat's fundic strip and uterine motility of female rats at various stages of sex cycle have been recorded and presented in Table 1. Action of cefepime on the rabbit duodenal motility is shown in Figure 1. The rat's fundic strip was depressed by cefepime in a dose-dependent manner and histamine was not able to produce its stimulant effect in presence of cefepime (Figure 2) so cefepime might appear to have an antihistaminic-like effect. Cefepime stimulated the uterine motility during estrus and nonestrus stages and depressed it during early and late pregnancy and these findings might be attributed to the direct effect of cefepime (Figures 3(a) and 3(b) and Figures 4(a) and 4(b)). Cefepime had no effect on the resting tonus of the isolated guinea pig's tracheal chain but histamine (60 μg/mL bath) was not able to produce its contractile effect in the presence of cefepime (400 μg/mL bath) as shown in Figure 5. This indicated that cefepime might have an antihistaminic like effect on this tissue.

Bottom Line: Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained.Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip.Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles.

View Article: PubMed Central - PubMed

Affiliation: Pharmacology Department, Faculty of Veterinary Medicine, Benha University, P.O. Box 13736, Moshtohor, Toukh, Elqaliobiya, Egypt.

ABSTRACT
Some pharmacodynamic effects of cefepime, a new injectable semisynthetic cephalosporin, were studied in laboratory animals and the following results were obtained. Cefepime maximally stimulated isolated guinea pig's ileum, rat's colon (80 μg/mL bath), and rabbit's duodenum (400 μg/mL bath). Contrarily, complete relaxation of isolated rat's fundic strip was produced by 80 μg/mL bath. Effects of cefepime on isolated rat's uterine muscle were different according to stage of sex cycle. Cefepime did not induce any effects on the resting tonus of isolated guinea pig's tracheal chain and rabbit's aortic strip. Concentrations of 200 and 400 μg/mL bath induced marked inhibition in the force of muscular twitches of the isolated frog's gastrocnemius muscle which was less potent than that induced by procaine hydrochloride 2%. Cefepime completely blocked the neuromuscular transmission of frog's rectus abdominis muscle (40 μg/mL bath) and rat's phrenic nerve hemidiaphragm preparation (200 μg/mL bath). This blockade was reversed by acetylcholine and neostigmine. Cefepime produced dose-dependent negative inotropic effect on isolated rabbit's heart and guinea pig's auricles. There were no changes in blood pressure and rate of respiration in anaesthetized dog after cefepime injection. These findings indicate that cefepime has a low potential to produce adverse reactions at therapeutic doses.

No MeSH data available.


Related in: MedlinePlus