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Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms.

Deepakumari HN, Revanasiddappa HD - J Pharm (Cairo) (2012)

Bottom Line: Beer's law was obeyed in the concentration range of 0-25 and 0-50 μg/mL with molar absorptivity of 1.29 × 10(4) and 0.48 × 10(4) L/moL/cm for RSP in methods A and B, respectively.The effects of variables such as reagents, time, and stability of the charge transfer complexes were investigated to optimize the procedures.Results indicate that the methods are accurate, precise, and reproducible (relative standard deviation <2 %).

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570006, India.

ABSTRACT
The aim of study was to develop and validate two simple, sensitive, and extraction-free spectrophotometric methods for the estimation of risperidone in both pure and pharmaceutical preparations. They are based on the charge transfer complexation reactions between risperidone (RSP) as n-electron donor and p-chloranilic acid (p-CA) in method A and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in method B as π-acceptors. In method A, RSP reacts with p-CA in methanol to produce a bright pink-colored chromogen measured at 530 nm whereas, in method B, RSP reacts with DDQ in dichloromethane to form orange-colored complex with a maximum absorption at 460 nm. Beer's law was obeyed in the concentration range of 0-25 and 0-50 μg/mL with molar absorptivity of 1.29 × 10(4) and 0.48 × 10(4) L/moL/cm for RSP in methods A and B, respectively. The effects of variables such as reagents, time, and stability of the charge transfer complexes were investigated to optimize the procedures. The proposed methods have been successfully applied to the determination of RSP in pharmaceutical formulations. Results indicate that the methods are accurate, precise, and reproducible (relative standard deviation <2 %).

No MeSH data available.


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Proposed reaction scheme for method B.
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sch2: Proposed reaction scheme for method B.

Mentions: Thus, p-CA and DDQ were used as reagents in the proposed methods A and B, respectively, for the estimation of RSP. The possible reaction pathway for RSP-p-CA and RSP-DDQ complexes was proposed and depicted in Schemes 1 and 2, respectively.


Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms.

Deepakumari HN, Revanasiddappa HD - J Pharm (Cairo) (2012)

Proposed reaction scheme for method B.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4595964&req=5

sch2: Proposed reaction scheme for method B.
Mentions: Thus, p-CA and DDQ were used as reagents in the proposed methods A and B, respectively, for the estimation of RSP. The possible reaction pathway for RSP-p-CA and RSP-DDQ complexes was proposed and depicted in Schemes 1 and 2, respectively.

Bottom Line: Beer's law was obeyed in the concentration range of 0-25 and 0-50 μg/mL with molar absorptivity of 1.29 × 10(4) and 0.48 × 10(4) L/moL/cm for RSP in methods A and B, respectively.The effects of variables such as reagents, time, and stability of the charge transfer complexes were investigated to optimize the procedures.Results indicate that the methods are accurate, precise, and reproducible (relative standard deviation <2 %).

View Article: PubMed Central - PubMed

Affiliation: Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570006, India.

ABSTRACT
The aim of study was to develop and validate two simple, sensitive, and extraction-free spectrophotometric methods for the estimation of risperidone in both pure and pharmaceutical preparations. They are based on the charge transfer complexation reactions between risperidone (RSP) as n-electron donor and p-chloranilic acid (p-CA) in method A and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in method B as π-acceptors. In method A, RSP reacts with p-CA in methanol to produce a bright pink-colored chromogen measured at 530 nm whereas, in method B, RSP reacts with DDQ in dichloromethane to form orange-colored complex with a maximum absorption at 460 nm. Beer's law was obeyed in the concentration range of 0-25 and 0-50 μg/mL with molar absorptivity of 1.29 × 10(4) and 0.48 × 10(4) L/moL/cm for RSP in methods A and B, respectively. The effects of variables such as reagents, time, and stability of the charge transfer complexes were investigated to optimize the procedures. The proposed methods have been successfully applied to the determination of RSP in pharmaceutical formulations. Results indicate that the methods are accurate, precise, and reproducible (relative standard deviation <2 %).

No MeSH data available.


Related in: MedlinePlus