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Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk).

Kuhnle GG, Tasevska N, Lentjes MA, Griffin JL, Sims MA, Richardson L, Aspinall SM, Mulligan AA, Luben RN, Khaw KT - Public Health Nutr (2015)

Bottom Line: Self-reported sucrose intake was significantly positively associated with the biomarker.Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI.Future studies should consider the use of objective biomarkers of sucrose intake.

View Article: PubMed Central - PubMed

Affiliation: 1Department of Food & Nutritional Sciences,University of Reading,Reading RG6 6AP,UK.

ABSTRACT

Objective: The objective of the present study was to investigate associations between sugar intake and overweight using dietary biomarkers in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).

Design: Prospective cohort study.

Setting: EPIC-Norfolk in the UK, recruitment between 1993 and 1997.

Subjects: Men and women (n 1734) aged 39-77 years. Sucrose intake was assessed using 7 d diet diaries. Baseline spot urine samples were analysed for sucrose by GC-MS. Sucrose concentration adjusted by specific gravity was used as a biomarker for intake. Regression analyses were used to investigate associations between sucrose intake and risk of BMI>25·0 kg/m2 after three years of follow-up.

Results: After three years of follow-up, mean BMI was 26·8 kg/m2. Self-reported sucrose intake was significantly positively associated with the biomarker. Associations between the biomarker and BMI were positive (β=0·25; 95 % CI 0·08, 0·43), while they were inverse when using self-reported dietary data (β=-1·40; 95 % CI -1·81, -0·99). The age- and sex-adjusted OR for BMI>25·0 kg/m2 in participants in the fifth v. first quintile was 1·54 (95 % CI 1·12, 2·12; P trend=0·003) when using biomarker and 0·56 (95 % CI 0·40, 0·77; P trend<0·001) with self-reported dietary data.

Conclusions: Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI. Future studies should consider the use of objective biomarkers of sucrose intake.

No MeSH data available.


Related in: MedlinePlus

Association between sucrose intake and risk of overweight or obesity after threeyears of follow-up using either dietary data (■, energy-adjusted, as assessed by 7 ddiet diary) or biomarker (●, urinary sucrose, adjusted by specific gravity) amongmen and women (n 1734) aged 39–77 years, Norfolk cohort of theEuropean Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).Presented are odds ratios with their 95 % confidence intervals represented byvertical bars (Q1, quintile 1 (lowest); Q2, quintile 2; Q3, quintile 3; Q4, quintile4; Q5, quintile 5 (highest))
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fig3: Association between sucrose intake and risk of overweight or obesity after threeyears of follow-up using either dietary data (■, energy-adjusted, as assessed by 7 ddiet diary) or biomarker (●, urinary sucrose, adjusted by specific gravity) amongmen and women (n 1734) aged 39–77 years, Norfolk cohort of theEuropean Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).Presented are odds ratios with their 95 % confidence intervals represented byvertical bars (Q1, quintile 1 (lowest); Q2, quintile 2; Q3, quintile 3; Q4, quintile4; Q5, quintile 5 (highest))

Mentions: There were significant associations between the biomarker and risk of being overweight orobese after three years of follow-up (Table 2,Fig. 3) with an OR of 1·54 (95 % CI 1·12, 2·12;P=0·008) between the top and bottom quintile and a significant trend(P=0·003) across quintiles. Stratification by sex showed a marginallynon-significant trend (P=0·054) in men and a significant(P=0·02) trend in women. Conversely, there was an inverse associationwhen using self-reported intake with an OR of 0·56 (95 % CI 0·40, 0·77;P<0·0001) and also a significant trend(P<0·0001). After stratification for sex, the trend remainedsignificant in both men and women. When using the biomarker as a continuous variable, theOR for BMI>25·0 kg/m2 was 1·16 (95 % CI 1·05, 1·27) per log increase.Conversely, the OR was 0·60 (95 % CI 0·47, 0·77) when using self-reported dietary data. Ananalysis of the association between intake and risk of being overweight or obese atbaseline gave similar results in the sex-adjusted model (see online supplementarymaterial, Supplemental Table 5).Fig. 3


Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk).

Kuhnle GG, Tasevska N, Lentjes MA, Griffin JL, Sims MA, Richardson L, Aspinall SM, Mulligan AA, Luben RN, Khaw KT - Public Health Nutr (2015)

Association between sucrose intake and risk of overweight or obesity after threeyears of follow-up using either dietary data (■, energy-adjusted, as assessed by 7 ddiet diary) or biomarker (●, urinary sucrose, adjusted by specific gravity) amongmen and women (n 1734) aged 39–77 years, Norfolk cohort of theEuropean Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).Presented are odds ratios with their 95 % confidence intervals represented byvertical bars (Q1, quintile 1 (lowest); Q2, quintile 2; Q3, quintile 3; Q4, quintile4; Q5, quintile 5 (highest))
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595857&req=5

fig3: Association between sucrose intake and risk of overweight or obesity after threeyears of follow-up using either dietary data (■, energy-adjusted, as assessed by 7 ddiet diary) or biomarker (●, urinary sucrose, adjusted by specific gravity) amongmen and women (n 1734) aged 39–77 years, Norfolk cohort of theEuropean Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).Presented are odds ratios with their 95 % confidence intervals represented byvertical bars (Q1, quintile 1 (lowest); Q2, quintile 2; Q3, quintile 3; Q4, quintile4; Q5, quintile 5 (highest))
Mentions: There were significant associations between the biomarker and risk of being overweight orobese after three years of follow-up (Table 2,Fig. 3) with an OR of 1·54 (95 % CI 1·12, 2·12;P=0·008) between the top and bottom quintile and a significant trend(P=0·003) across quintiles. Stratification by sex showed a marginallynon-significant trend (P=0·054) in men and a significant(P=0·02) trend in women. Conversely, there was an inverse associationwhen using self-reported intake with an OR of 0·56 (95 % CI 0·40, 0·77;P<0·0001) and also a significant trend(P<0·0001). After stratification for sex, the trend remainedsignificant in both men and women. When using the biomarker as a continuous variable, theOR for BMI>25·0 kg/m2 was 1·16 (95 % CI 1·05, 1·27) per log increase.Conversely, the OR was 0·60 (95 % CI 0·47, 0·77) when using self-reported dietary data. Ananalysis of the association between intake and risk of being overweight or obese atbaseline gave similar results in the sex-adjusted model (see online supplementarymaterial, Supplemental Table 5).Fig. 3

Bottom Line: Self-reported sucrose intake was significantly positively associated with the biomarker.Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI.Future studies should consider the use of objective biomarkers of sucrose intake.

View Article: PubMed Central - PubMed

Affiliation: 1Department of Food & Nutritional Sciences,University of Reading,Reading RG6 6AP,UK.

ABSTRACT

Objective: The objective of the present study was to investigate associations between sugar intake and overweight using dietary biomarkers in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).

Design: Prospective cohort study.

Setting: EPIC-Norfolk in the UK, recruitment between 1993 and 1997.

Subjects: Men and women (n 1734) aged 39-77 years. Sucrose intake was assessed using 7 d diet diaries. Baseline spot urine samples were analysed for sucrose by GC-MS. Sucrose concentration adjusted by specific gravity was used as a biomarker for intake. Regression analyses were used to investigate associations between sucrose intake and risk of BMI>25·0 kg/m2 after three years of follow-up.

Results: After three years of follow-up, mean BMI was 26·8 kg/m2. Self-reported sucrose intake was significantly positively associated with the biomarker. Associations between the biomarker and BMI were positive (β=0·25; 95 % CI 0·08, 0·43), while they were inverse when using self-reported dietary data (β=-1·40; 95 % CI -1·81, -0·99). The age- and sex-adjusted OR for BMI>25·0 kg/m2 in participants in the fifth v. first quintile was 1·54 (95 % CI 1·12, 2·12; P trend=0·003) when using biomarker and 0·56 (95 % CI 0·40, 0·77; P trend<0·001) with self-reported dietary data.

Conclusions: Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI. Future studies should consider the use of objective biomarkers of sucrose intake.

No MeSH data available.


Related in: MedlinePlus