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Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk).

Kuhnle GG, Tasevska N, Lentjes MA, Griffin JL, Sims MA, Richardson L, Aspinall SM, Mulligan AA, Luben RN, Khaw KT - Public Health Nutr (2015)

Bottom Line: Self-reported sucrose intake was significantly positively associated with the biomarker.Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI.Future studies should consider the use of objective biomarkers of sucrose intake.

View Article: PubMed Central - PubMed

Affiliation: 1Department of Food & Nutritional Sciences,University of Reading,Reading RG6 6AP,UK.

ABSTRACT

Objective: The objective of the present study was to investigate associations between sugar intake and overweight using dietary biomarkers in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).

Design: Prospective cohort study.

Setting: EPIC-Norfolk in the UK, recruitment between 1993 and 1997.

Subjects: Men and women (n 1734) aged 39-77 years. Sucrose intake was assessed using 7 d diet diaries. Baseline spot urine samples were analysed for sucrose by GC-MS. Sucrose concentration adjusted by specific gravity was used as a biomarker for intake. Regression analyses were used to investigate associations between sucrose intake and risk of BMI>25·0 kg/m2 after three years of follow-up.

Results: After three years of follow-up, mean BMI was 26·8 kg/m2. Self-reported sucrose intake was significantly positively associated with the biomarker. Associations between the biomarker and BMI were positive (β=0·25; 95 % CI 0·08, 0·43), while they were inverse when using self-reported dietary data (β=-1·40; 95 % CI -1·81, -0·99). The age- and sex-adjusted OR for BMI>25·0 kg/m2 in participants in the fifth v. first quintile was 1·54 (95 % CI 1·12, 2·12; P trend=0·003) when using biomarker and 0·56 (95 % CI 0·40, 0·77; P trend<0·001) with self-reported dietary data.

Conclusions: Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI. Future studies should consider the use of objective biomarkers of sucrose intake.

No MeSH data available.


Related in: MedlinePlus

Study population and sample size (2HC, second health check; LLOQ, lower limit ofquantification; ULOQ, upper limit of quantification)
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fig1: Study population and sample size (2HC, second health check; LLOQ, lower limit ofquantification; ULOQ, upper limit of quantification)

Mentions: Baseline spot urine samples (n5993) were selected randomly from thestorage facility. While this selection was random, the samples are not necessarily arepresentative selection of the cohort. Co-variables (sex, dietary data and specificgravity) were missing for 155 participants and end points (anthropometric data) weremissing for a further 2467 who did not attend the second health examination. Urinarysucrose analyses failed for 195 participants and results were outside the calibrationrange for 1442 participants, leaving a total sample size of 1734 (see Fig. 1 for details). For sensitivity analyses, sucrose concentrationsbelow and above the limits of quantification (<5·0 µm or>500µm) were imputed with 4·9 µm and 500·1 µm, respectively.Fig. 1


Association between sucrose intake and risk of overweight and obesity in a prospective sub-cohort of the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk).

Kuhnle GG, Tasevska N, Lentjes MA, Griffin JL, Sims MA, Richardson L, Aspinall SM, Mulligan AA, Luben RN, Khaw KT - Public Health Nutr (2015)

Study population and sample size (2HC, second health check; LLOQ, lower limit ofquantification; ULOQ, upper limit of quantification)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595857&req=5

fig1: Study population and sample size (2HC, second health check; LLOQ, lower limit ofquantification; ULOQ, upper limit of quantification)
Mentions: Baseline spot urine samples (n5993) were selected randomly from thestorage facility. While this selection was random, the samples are not necessarily arepresentative selection of the cohort. Co-variables (sex, dietary data and specificgravity) were missing for 155 participants and end points (anthropometric data) weremissing for a further 2467 who did not attend the second health examination. Urinarysucrose analyses failed for 195 participants and results were outside the calibrationrange for 1442 participants, leaving a total sample size of 1734 (see Fig. 1 for details). For sensitivity analyses, sucrose concentrationsbelow and above the limits of quantification (<5·0 µm or>500µm) were imputed with 4·9 µm and 500·1 µm, respectively.Fig. 1

Bottom Line: Self-reported sucrose intake was significantly positively associated with the biomarker.Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI.Future studies should consider the use of objective biomarkers of sucrose intake.

View Article: PubMed Central - PubMed

Affiliation: 1Department of Food & Nutritional Sciences,University of Reading,Reading RG6 6AP,UK.

ABSTRACT

Objective: The objective of the present study was to investigate associations between sugar intake and overweight using dietary biomarkers in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk).

Design: Prospective cohort study.

Setting: EPIC-Norfolk in the UK, recruitment between 1993 and 1997.

Subjects: Men and women (n 1734) aged 39-77 years. Sucrose intake was assessed using 7 d diet diaries. Baseline spot urine samples were analysed for sucrose by GC-MS. Sucrose concentration adjusted by specific gravity was used as a biomarker for intake. Regression analyses were used to investigate associations between sucrose intake and risk of BMI>25·0 kg/m2 after three years of follow-up.

Results: After three years of follow-up, mean BMI was 26·8 kg/m2. Self-reported sucrose intake was significantly positively associated with the biomarker. Associations between the biomarker and BMI were positive (β=0·25; 95 % CI 0·08, 0·43), while they were inverse when using self-reported dietary data (β=-1·40; 95 % CI -1·81, -0·99). The age- and sex-adjusted OR for BMI>25·0 kg/m2 in participants in the fifth v. first quintile was 1·54 (95 % CI 1·12, 2·12; P trend=0·003) when using biomarker and 0·56 (95 % CI 0·40, 0·77; P trend<0·001) with self-reported dietary data.

Conclusions: Our results suggest that sucrose measured by objective biomarker but not self-reported sucrose intake is positively associated with BMI. Future studies should consider the use of objective biomarkers of sucrose intake.

No MeSH data available.


Related in: MedlinePlus