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Household physical activity and cancer risk: a systematic review and dose-response meta-analysis of epidemiological studies.

Shi Y, Li T, Wang Y, Zhou L, Qin Q, Yin J, Wei S, Liu L, Nie S - Sci Rep (2015)

Bottom Line: Random-effect models were conducted to estimate the summary relative risks (RRs), nonlinear or linear dose-response meta-analyses were performed to estimate the trend from the correlated log RR estimates across levels of household physical activity quantitatively.Total cancer risks were reduced 16% among the people with highest household physical activity compared to those with lowest household physical activity (RR = 0.84, 95% CI = 0.76-0.93).These findings provide quantitative data supporting household physical activity is associated with decreased cancer risk in dose-response effect.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

ABSTRACT
Controversial results of the association between household physical activity and cancer risk were reported among previous epidemiological studies. We conducted a meta-analysis to investigate the relationship of household physical activity and cancer risk quantitatively, especially in dose-response manner. PubMed, Embase, Web of science and the Cochrane Library were searched for cohort or case-control studies that examined the association between household physical activity and cancer risks. Random-effect models were conducted to estimate the summary relative risks (RRs), nonlinear or linear dose-response meta-analyses were performed to estimate the trend from the correlated log RR estimates across levels of household physical activity quantitatively. Totally, 30 studies including 41 comparisons met the inclusion criteria. Total cancer risks were reduced 16% among the people with highest household physical activity compared to those with lowest household physical activity (RR = 0.84, 95% CI = 0.76-0.93). The dose-response analyses indicated an inverse linear association between household physical activity and cancer risk. The relative risk was 0.98 (95% CI = 0.97-1.00) for per additional 10 MET-hours/week and it was 0.99 (95% CI = 0.98-0.99) for per 1 hour/week increase. These findings provide quantitative data supporting household physical activity is associated with decreased cancer risk in dose-response effect.

No MeSH data available.


Related in: MedlinePlus

Forest plots of highest versus lowest meta-analysis on the relationship between household physical activity and cancer risk.
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f2: Forest plots of highest versus lowest meta-analysis on the relationship between household physical activity and cancer risk.

Mentions: All studies with 41 comparisons456789101112131415161718192021222324252627282930313233 were included for highest versus lowest analysis, which consisted of 2,242,789 participants and 33,949 cancer cases. Compared with lowest household physical activity level, the highest level had a summary RR of 0.84 (95% CI = 0.76–0.93, I2for heterogeneity = 75.6%; Fig. 2). Table 1 presents the results of subgroup analyses. A significant inverse association between household physical activity and cancer risk was found in both cohort studies and case-control studies. However, pooled estimate from cohort comparisons was more conservative with the summary relative risks of 0.92 (95% CI = 0.87–0.97, I2for heterogeneity = 0.1%; Table 1), compared with 0.77 (95% CI = 0.65–0.92, I2for heterogeneity = 82.4%; Table 1) from case-control studies. Geographically, active household physical activity resulted in cancer risk reduction in Asia (RR = 0.76, 95% CI = 0.65–0.90), but not in America (RR = 0.83, 95% CI = 0.59–1.18) or Europe (RR = 0.92, 95% CI = 0.82–1.02). A significant inverse association between household physical activity and cancer risk was observed in women (RR = 0.78, 95% CI = 0.69–0.88) but not in men (RR = 1.04, 95% CI = 0.84–1.30). When further stratified sex by study design and location, the results also showed significant association for women but non-significant association for men. Besides, we examined whether obesity mediated the inverse relation of household physical activity with cancer risk in subgroup analyses. The inverse association of household physical activity to cancer risk was statistically significant in studies adjusting for BMI/weight (RR = 0.80, 95% CI = 0.71–0.90) but it was not significant in studies without adjustment for BMI/weight (RR = 0.93, 95% CI = 0.78–1.10).


Household physical activity and cancer risk: a systematic review and dose-response meta-analysis of epidemiological studies.

Shi Y, Li T, Wang Y, Zhou L, Qin Q, Yin J, Wei S, Liu L, Nie S - Sci Rep (2015)

Forest plots of highest versus lowest meta-analysis on the relationship between household physical activity and cancer risk.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595663&req=5

f2: Forest plots of highest versus lowest meta-analysis on the relationship between household physical activity and cancer risk.
Mentions: All studies with 41 comparisons456789101112131415161718192021222324252627282930313233 were included for highest versus lowest analysis, which consisted of 2,242,789 participants and 33,949 cancer cases. Compared with lowest household physical activity level, the highest level had a summary RR of 0.84 (95% CI = 0.76–0.93, I2for heterogeneity = 75.6%; Fig. 2). Table 1 presents the results of subgroup analyses. A significant inverse association between household physical activity and cancer risk was found in both cohort studies and case-control studies. However, pooled estimate from cohort comparisons was more conservative with the summary relative risks of 0.92 (95% CI = 0.87–0.97, I2for heterogeneity = 0.1%; Table 1), compared with 0.77 (95% CI = 0.65–0.92, I2for heterogeneity = 82.4%; Table 1) from case-control studies. Geographically, active household physical activity resulted in cancer risk reduction in Asia (RR = 0.76, 95% CI = 0.65–0.90), but not in America (RR = 0.83, 95% CI = 0.59–1.18) or Europe (RR = 0.92, 95% CI = 0.82–1.02). A significant inverse association between household physical activity and cancer risk was observed in women (RR = 0.78, 95% CI = 0.69–0.88) but not in men (RR = 1.04, 95% CI = 0.84–1.30). When further stratified sex by study design and location, the results also showed significant association for women but non-significant association for men. Besides, we examined whether obesity mediated the inverse relation of household physical activity with cancer risk in subgroup analyses. The inverse association of household physical activity to cancer risk was statistically significant in studies adjusting for BMI/weight (RR = 0.80, 95% CI = 0.71–0.90) but it was not significant in studies without adjustment for BMI/weight (RR = 0.93, 95% CI = 0.78–1.10).

Bottom Line: Random-effect models were conducted to estimate the summary relative risks (RRs), nonlinear or linear dose-response meta-analyses were performed to estimate the trend from the correlated log RR estimates across levels of household physical activity quantitatively.Total cancer risks were reduced 16% among the people with highest household physical activity compared to those with lowest household physical activity (RR = 0.84, 95% CI = 0.76-0.93).These findings provide quantitative data supporting household physical activity is associated with decreased cancer risk in dose-response effect.

View Article: PubMed Central - PubMed

Affiliation: Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

ABSTRACT
Controversial results of the association between household physical activity and cancer risk were reported among previous epidemiological studies. We conducted a meta-analysis to investigate the relationship of household physical activity and cancer risk quantitatively, especially in dose-response manner. PubMed, Embase, Web of science and the Cochrane Library were searched for cohort or case-control studies that examined the association between household physical activity and cancer risks. Random-effect models were conducted to estimate the summary relative risks (RRs), nonlinear or linear dose-response meta-analyses were performed to estimate the trend from the correlated log RR estimates across levels of household physical activity quantitatively. Totally, 30 studies including 41 comparisons met the inclusion criteria. Total cancer risks were reduced 16% among the people with highest household physical activity compared to those with lowest household physical activity (RR = 0.84, 95% CI = 0.76-0.93). The dose-response analyses indicated an inverse linear association between household physical activity and cancer risk. The relative risk was 0.98 (95% CI = 0.97-1.00) for per additional 10 MET-hours/week and it was 0.99 (95% CI = 0.98-0.99) for per 1 hour/week increase. These findings provide quantitative data supporting household physical activity is associated with decreased cancer risk in dose-response effect.

No MeSH data available.


Related in: MedlinePlus