Influence of tumour stage at breast cancer detection on survival in modern times: population based study in 173,797 patients.
Bottom Line: Relative survival was compared between the two cohorts.Influence of traditional prognostic factors on overall mortality was analysed with Cox regression for each cohort separately.Median follow-up was 9.8 years for 1999-2005 and 3.9 years for 2006-12.
Affiliation: Department of Surgery, Erasmus University Medical Centre - Cancer Institute, 3075 EA, Rotterdam, Netherlands.Show MeSH
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Mentions: Median follow-up was 9.8 (range 0-15) years for the first cohort (1999-2005) and 3.9 (0-8) years for the second cohort (2006-12). During follow-up, 27 924 events occurred in the first cohort and 11 177 in the second cohort. We plotted relative survival curves for both tumour stage (fig 1) and nodal stage (fig 2). Compared with 1999-2005, five year relative survival rates and overall survival rates were higher for the 2006-12 cohort for all tumour and nodal stages (table 2). Relative survival of ductal carcinoma in situ was 100% after 15 years for the 1999-2005 cohort and 101% after 8 years for the 2006-12 cohort. Relative survival decreased with increasing tumour and nodal stages, except for T1b versus T1a (1999-2005 100% v 99%; 2006-12 101% v 100%). Relative survival in the 1999-2005 cohort did not decrease after nine years for all tumour sizes T1c or smaller and after 13 years for tumours T2 or larger. In the 2006-12 cohort, no decrease in relative survival was seen in tumour sizes T2 or smaller after six years and for tumour sizes larger than T2 after seven years.
Affiliation: Department of Surgery, Erasmus University Medical Centre - Cancer Institute, 3075 EA, Rotterdam, Netherlands.