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The Brain Activity in Brodmann Area 17: A Potential Bio-Marker to Predict Patient Responses to Antiepileptic Drugs.

Hu Y, Mi X, Xu X, Fang W, Zeng K, Yang M, Li C, Wang S, Li M, Wang X - PLoS ONE (2015)

Bottom Line: By calculating the amplitude of fractional low-frequency fluctuations (fALFF) of blood oxygen level-dependent signals to measure brain activity during rest, we found that the SUC patients showed increased activity in the bilateral occipital lobe, particularly in the cuneus and lingual gyrus compared with the SC group and healthy controls.Interestingly, DR patients also showed increased activity in the identical cuneus and lingual gyrus regions, which comprise Brodmann's area 17 (BA17), compared with the SUC patients; however, these abnormalities were not observed in SC and WH patients.Regions nearby the cuneus and lingual gyrus were found positive connectivity increased changes or positive connectivity changes with BA17 in the SUC patients, while remarkably negative connectivity increased changes or positive connectivity decreased changes were found in the SC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

ABSTRACT
In this study, we aimed to predict newly diagnosed patient responses to antiepileptic drugs (AEDs) using resting-state functional magnetic resonance imaging tools to explore changes in spontaneous brain activity. We recruited 21 newly diagnosed epileptic patients, 8 drug-resistant (DR) patients, 11 well-healed (WH) patients, and 13 healthy controls. After a 12-month follow-up, 11 newly diagnosed epileptic patients who showed a poor response to AEDs were placed into the seizures uncontrolled (SUC) group, while 10 patients were enrolled in the seizure-controlled (SC) group. By calculating the amplitude of fractional low-frequency fluctuations (fALFF) of blood oxygen level-dependent signals to measure brain activity during rest, we found that the SUC patients showed increased activity in the bilateral occipital lobe, particularly in the cuneus and lingual gyrus compared with the SC group and healthy controls. Interestingly, DR patients also showed increased activity in the identical cuneus and lingual gyrus regions, which comprise Brodmann's area 17 (BA17), compared with the SUC patients; however, these abnormalities were not observed in SC and WH patients. The receiver operating characteristic (ROC) curves indicated that the fALFF value of BA17 could differentiate SUC patients from SC patients and healthy controls with sufficient sensitivity and specificity prior to the administration of medication. Functional connectivity analysis was subsequently performed to evaluate the difference in connectivity between BA17 and other brain regions in the SUC, SC and control groups. Regions nearby the cuneus and lingual gyrus were found positive connectivity increased changes or positive connectivity changes with BA17 in the SUC patients, while remarkably negative connectivity increased changes or positive connectivity decreased changes were found in the SC patients. Additionally, default mode network (DMN) regions showed negative connectivity increased changes or negative changes with BA17 in the SUC patients. The abnormal increased in BA17 activity may be a key point that plays a substantial role in facilitating seizure onset.

No MeSH data available.


Related in: MedlinePlus

Maps of fALFF differences.A: SUC vs. control. Compared with healthy controls, the SUC patients showed significantly increased fALFF values in the warm color regions, including the bilateral cuneus, bilateral lingual gyrus, bilateral superior/middle/inferior occipital gyrus, and right posterior cingulate. B: SUC vs. SC. Compared with SC patients, the SUC patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral lingual gyrus, bilateral middle temporal-occipital area, and right fusiform gyrus. C: DR vs. controls. The DR patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral middle occipital gyrus, bilateral fusiform, and right middle temporal-occipital area. D: DR vs. WH. Compared with WH patients, the DR patients showed significantly increased fALFF values in the warm color regions of the left cuneus, bilateral fusiform, and right middle occipital gyrus. E: SC vs. CON. Compared with the healthy controls, the SC patients showed significantly increased fALFF values in the warm color region of the left inferior occipital gyrus. In contrast, the cold color regions in the right fusiform gyrus represent the area with decreased fALFF values in SC patients compared with controls. F: WH vs. CON. The WH patients showed only showed decreased fALFF values in the cold color region of the right fusiform gyrus. The statistical threshold was set at P < 0.05 with a cluster size > 351 mm3, which corresponded to a corrected P < 0.05.
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pone.0139819.g002: Maps of fALFF differences.A: SUC vs. control. Compared with healthy controls, the SUC patients showed significantly increased fALFF values in the warm color regions, including the bilateral cuneus, bilateral lingual gyrus, bilateral superior/middle/inferior occipital gyrus, and right posterior cingulate. B: SUC vs. SC. Compared with SC patients, the SUC patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral lingual gyrus, bilateral middle temporal-occipital area, and right fusiform gyrus. C: DR vs. controls. The DR patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral middle occipital gyrus, bilateral fusiform, and right middle temporal-occipital area. D: DR vs. WH. Compared with WH patients, the DR patients showed significantly increased fALFF values in the warm color regions of the left cuneus, bilateral fusiform, and right middle occipital gyrus. E: SC vs. CON. Compared with the healthy controls, the SC patients showed significantly increased fALFF values in the warm color region of the left inferior occipital gyrus. In contrast, the cold color regions in the right fusiform gyrus represent the area with decreased fALFF values in SC patients compared with controls. F: WH vs. CON. The WH patients showed only showed decreased fALFF values in the cold color region of the right fusiform gyrus. The statistical threshold was set at P < 0.05 with a cluster size > 351 mm3, which corresponded to a corrected P < 0.05.

Mentions: Fig 2A and Table B in S1 File show the fALFF differences between SUC patients and healthy controls. Only regions with significant fALFF increases were found including the bilateral cuneus, lingual gyrus, superior/middle/inferior occipital gyrus, and right posterior cingulate. Fig 2B shows the comparison of fALFF values between the SUC and SC patients. Interestingly, compared with the SC patients, we also observed significantly higher fALFF values in the bilateral cuneus and lingual gyrus in the SUC patients. The bilateral middle temporal-occipital area and right fusiform gyrus were other parts with higher fALFF values in the SUC patients than the SC patients. Table C in S1 File shows the detailed list of these regions. Fig 2C and Table D in S1 File show the comparison between DR patients and controls. The bilateral cuneus, middle occipital gyrus, fusiform, and the right middle temporal-occipital area had higher fALFF in DR patients than in controls. Fig 2D and Table E in S1 File represent the differences between the DR and WH groups. The bilateral fusiform, the left cuneus and the right middle occipital gyrus showed higher fALFF in DR patients than in WH patients. Fig 2E and Table F in S1 File show two regions have significantly different fALFF values in SC patients compared with healthy controls: the fALFF-increased area of the left inferior occipital gyrus and the fALFF-decreased area of the right fusiform. Fig 2F and Table G in S1 File represent one region with significantly decreased fALFF in the right fusiform in WH patients compared with healthy controls.


The Brain Activity in Brodmann Area 17: A Potential Bio-Marker to Predict Patient Responses to Antiepileptic Drugs.

Hu Y, Mi X, Xu X, Fang W, Zeng K, Yang M, Li C, Wang S, Li M, Wang X - PLoS ONE (2015)

Maps of fALFF differences.A: SUC vs. control. Compared with healthy controls, the SUC patients showed significantly increased fALFF values in the warm color regions, including the bilateral cuneus, bilateral lingual gyrus, bilateral superior/middle/inferior occipital gyrus, and right posterior cingulate. B: SUC vs. SC. Compared with SC patients, the SUC patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral lingual gyrus, bilateral middle temporal-occipital area, and right fusiform gyrus. C: DR vs. controls. The DR patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral middle occipital gyrus, bilateral fusiform, and right middle temporal-occipital area. D: DR vs. WH. Compared with WH patients, the DR patients showed significantly increased fALFF values in the warm color regions of the left cuneus, bilateral fusiform, and right middle occipital gyrus. E: SC vs. CON. Compared with the healthy controls, the SC patients showed significantly increased fALFF values in the warm color region of the left inferior occipital gyrus. In contrast, the cold color regions in the right fusiform gyrus represent the area with decreased fALFF values in SC patients compared with controls. F: WH vs. CON. The WH patients showed only showed decreased fALFF values in the cold color region of the right fusiform gyrus. The statistical threshold was set at P < 0.05 with a cluster size > 351 mm3, which corresponded to a corrected P < 0.05.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4595505&req=5

pone.0139819.g002: Maps of fALFF differences.A: SUC vs. control. Compared with healthy controls, the SUC patients showed significantly increased fALFF values in the warm color regions, including the bilateral cuneus, bilateral lingual gyrus, bilateral superior/middle/inferior occipital gyrus, and right posterior cingulate. B: SUC vs. SC. Compared with SC patients, the SUC patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral lingual gyrus, bilateral middle temporal-occipital area, and right fusiform gyrus. C: DR vs. controls. The DR patients showed significantly increased fALFF values in the warm color regions of the bilateral cuneus, bilateral middle occipital gyrus, bilateral fusiform, and right middle temporal-occipital area. D: DR vs. WH. Compared with WH patients, the DR patients showed significantly increased fALFF values in the warm color regions of the left cuneus, bilateral fusiform, and right middle occipital gyrus. E: SC vs. CON. Compared with the healthy controls, the SC patients showed significantly increased fALFF values in the warm color region of the left inferior occipital gyrus. In contrast, the cold color regions in the right fusiform gyrus represent the area with decreased fALFF values in SC patients compared with controls. F: WH vs. CON. The WH patients showed only showed decreased fALFF values in the cold color region of the right fusiform gyrus. The statistical threshold was set at P < 0.05 with a cluster size > 351 mm3, which corresponded to a corrected P < 0.05.
Mentions: Fig 2A and Table B in S1 File show the fALFF differences between SUC patients and healthy controls. Only regions with significant fALFF increases were found including the bilateral cuneus, lingual gyrus, superior/middle/inferior occipital gyrus, and right posterior cingulate. Fig 2B shows the comparison of fALFF values between the SUC and SC patients. Interestingly, compared with the SC patients, we also observed significantly higher fALFF values in the bilateral cuneus and lingual gyrus in the SUC patients. The bilateral middle temporal-occipital area and right fusiform gyrus were other parts with higher fALFF values in the SUC patients than the SC patients. Table C in S1 File shows the detailed list of these regions. Fig 2C and Table D in S1 File show the comparison between DR patients and controls. The bilateral cuneus, middle occipital gyrus, fusiform, and the right middle temporal-occipital area had higher fALFF in DR patients than in controls. Fig 2D and Table E in S1 File represent the differences between the DR and WH groups. The bilateral fusiform, the left cuneus and the right middle occipital gyrus showed higher fALFF in DR patients than in WH patients. Fig 2E and Table F in S1 File show two regions have significantly different fALFF values in SC patients compared with healthy controls: the fALFF-increased area of the left inferior occipital gyrus and the fALFF-decreased area of the right fusiform. Fig 2F and Table G in S1 File represent one region with significantly decreased fALFF in the right fusiform in WH patients compared with healthy controls.

Bottom Line: By calculating the amplitude of fractional low-frequency fluctuations (fALFF) of blood oxygen level-dependent signals to measure brain activity during rest, we found that the SUC patients showed increased activity in the bilateral occipital lobe, particularly in the cuneus and lingual gyrus compared with the SC group and healthy controls.Interestingly, DR patients also showed increased activity in the identical cuneus and lingual gyrus regions, which comprise Brodmann's area 17 (BA17), compared with the SUC patients; however, these abnormalities were not observed in SC and WH patients.Regions nearby the cuneus and lingual gyrus were found positive connectivity increased changes or positive connectivity changes with BA17 in the SUC patients, while remarkably negative connectivity increased changes or positive connectivity decreased changes were found in the SC patients.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

ABSTRACT
In this study, we aimed to predict newly diagnosed patient responses to antiepileptic drugs (AEDs) using resting-state functional magnetic resonance imaging tools to explore changes in spontaneous brain activity. We recruited 21 newly diagnosed epileptic patients, 8 drug-resistant (DR) patients, 11 well-healed (WH) patients, and 13 healthy controls. After a 12-month follow-up, 11 newly diagnosed epileptic patients who showed a poor response to AEDs were placed into the seizures uncontrolled (SUC) group, while 10 patients were enrolled in the seizure-controlled (SC) group. By calculating the amplitude of fractional low-frequency fluctuations (fALFF) of blood oxygen level-dependent signals to measure brain activity during rest, we found that the SUC patients showed increased activity in the bilateral occipital lobe, particularly in the cuneus and lingual gyrus compared with the SC group and healthy controls. Interestingly, DR patients also showed increased activity in the identical cuneus and lingual gyrus regions, which comprise Brodmann's area 17 (BA17), compared with the SUC patients; however, these abnormalities were not observed in SC and WH patients. The receiver operating characteristic (ROC) curves indicated that the fALFF value of BA17 could differentiate SUC patients from SC patients and healthy controls with sufficient sensitivity and specificity prior to the administration of medication. Functional connectivity analysis was subsequently performed to evaluate the difference in connectivity between BA17 and other brain regions in the SUC, SC and control groups. Regions nearby the cuneus and lingual gyrus were found positive connectivity increased changes or positive connectivity changes with BA17 in the SUC patients, while remarkably negative connectivity increased changes or positive connectivity decreased changes were found in the SC patients. Additionally, default mode network (DMN) regions showed negative connectivity increased changes or negative changes with BA17 in the SUC patients. The abnormal increased in BA17 activity may be a key point that plays a substantial role in facilitating seizure onset.

No MeSH data available.


Related in: MedlinePlus