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Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children.

Resch Y, Michel S, Kabesch M, Lupinek C, Valenta R, Vrtala S - J. Allergy Clin. Immunol. (2015)

Bottom Line: House dust mites (HDMs) represent one of the most important inducers of respiratory allergies worldwide.By contrast, fewer asthmatic children showed IgG reactivity to HDM allergens than nonasthmatic children, but allergen-specific IgG levels were comparable.In fact, asthmatic children were characterized by an expanded IgE repertoire regarding the numbers of recognized allergen components and by increased specific IgE levels.

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Affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

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Mentions: Significantly lower HDM allergen-specific IgG levels were found in the nonatopic children compared with the asthmatic and nonasthmatic groups with HDM allergy for all allergens except rDer p 23 (see Fig E4 in this article's Online Repository at www.jacionline.org).


Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children.

Resch Y, Michel S, Kabesch M, Lupinek C, Valenta R, Vrtala S - J. Allergy Clin. Immunol. (2015)

© Copyright Policy - CC BY
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595482&req=5

Mentions: Significantly lower HDM allergen-specific IgG levels were found in the nonatopic children compared with the asthmatic and nonasthmatic groups with HDM allergy for all allergens except rDer p 23 (see Fig E4 in this article's Online Repository at www.jacionline.org).

Bottom Line: House dust mites (HDMs) represent one of the most important inducers of respiratory allergies worldwide.By contrast, fewer asthmatic children showed IgG reactivity to HDM allergens than nonasthmatic children, but allergen-specific IgG levels were comparable.In fact, asthmatic children were characterized by an expanded IgE repertoire regarding the numbers of recognized allergen components and by increased specific IgE levels.

View Article: PubMed Central - PubMed

Affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Show MeSH
Related in: MedlinePlus