Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children.
Bottom Line: House dust mites (HDMs) represent one of the most important inducers of respiratory allergies worldwide.Sera from clinically well-characterized asthmatic children with HDM allergy (n = 105), nonasthmatic children (n = 53), and nonatopic nonasthmatic children (n = 53) were analyzed for IgE and IgG reactivity to a panel of 7 HDM allergens (nDer p 1, rDer p 2, rDer p 5, rDer p 7, rDer p 10, rDer p 21, and rDer p 23) by means of allergen microarray technology.By contrast, fewer asthmatic children showed IgG reactivity to HDM allergens than nonasthmatic children, but allergen-specific IgG levels were comparable.
Affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.Show MeSH
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Mentions: Significantly lower HDM allergen-specific IgG levels were found in the nonatopic children compared with the asthmatic and nonasthmatic groups with HDM allergy for all allergens except rDer p 23 (see Fig E4 in this article's Online Repository at www.jacionline.org).
Affiliation: Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.