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Hyperuricemia Inversely Correlates with Disease Severity in Taiwanese Nonalcoholic Steatohepatitis Patients.

Huang JF, Yeh ML, Yu ML, Huang CF, Dai CY, Hsieh MY, Hsieh MH, Huang CI, Lin ZY, Chen SC, Hsiao PJ, Shin SJ, Chuang WL - PLoS ONE (2015)

Bottom Line: Asians are more susceptible to non-alcoholic steatohepatitis (NASH) as well as metabolic disorder than other ethnicities.Multivariate logistic regression analysis showed that a decreased serum albumin level (OR = 40.0, 95% CI = 4.5-300, P = 0.001) and normal uric acid level (OR = 5.6, 95% CI = 1.5-21.7, P = 0.01) were the significant factors associated with significant fibrosis.Females might carry a more disease severity than males in Taiwanese NASH patients.

View Article: PubMed Central - PubMed

Affiliation: Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

ABSTRACT

Background & aims: Asians are more susceptible to non-alcoholic steatohepatitis (NASH) as well as metabolic disorder than other ethnicities. We aimed to assess the interaction between metabolic factors and fibrosis in Taiwanese NASH patients.

Methods: A total of 130 biopsy-proven Taiwanese NASH patients (94 males, age = 43.0 ± 13.0 years) were consecutively enrolled. Their demographic, metabolic profiles and histopathological manifestations were analyzed.

Results: Twenty-four (18.5%) NASH patients were non-obese. Thirty-three (25.4%) patients had significant fibrosis (F2) or more: 22 (16.9%) patients were of F2, whilst 11 (8.5%) patients were of advanced fibrosis (F3-4). The prevalence of metabolic syndrome, diabetes and hypertension were 60.8%, 39.4%, and 61.5%, respectively. There was a significant inverse correlation between hyperuricemia and fibrosis stages, ranging from 48.4% of F0-1, 33.3% of F2, and 9.1% of F3-4, respectively (P = 0.01, linear trend). Multivariate logistic regression analysis showed that a decreased serum albumin level (OR = 40.0, 95% CI = 4.5-300, P = 0.001) and normal uric acid level (OR = 5.6, 95% CI = 1.5-21.7, P = 0.01) were the significant factors associated with significant fibrosis.

Conclusions: Hyperuricemia inversely predicts fibrosis stages. Females might carry a more disease severity than males in Taiwanese NASH patients.

No MeSH data available.


Related in: MedlinePlus

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pone.0139796.g001: The flowchart of the study.

Mentions: A total of 166 NAFLD patients were consecutively recruited into histopathological surveillance. Thirty-six patients were excluded, including 20 patients presenting with simple steatosis, 11 patients of other causes of steatosis, and 5 patients of undetermined histopathological manifestations, respectively. A total of 130 NASH patients (94 males, age = 43.0 ± 13.0 years) were enrolled into final analysis (Fig 1). Their demographic characteristics were shown in Table 1.


Hyperuricemia Inversely Correlates with Disease Severity in Taiwanese Nonalcoholic Steatohepatitis Patients.

Huang JF, Yeh ML, Yu ML, Huang CF, Dai CY, Hsieh MY, Hsieh MH, Huang CI, Lin ZY, Chen SC, Hsiao PJ, Shin SJ, Chuang WL - PLoS ONE (2015)

The flowchart of the study.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595446&req=5

pone.0139796.g001: The flowchart of the study.
Mentions: A total of 166 NAFLD patients were consecutively recruited into histopathological surveillance. Thirty-six patients were excluded, including 20 patients presenting with simple steatosis, 11 patients of other causes of steatosis, and 5 patients of undetermined histopathological manifestations, respectively. A total of 130 NASH patients (94 males, age = 43.0 ± 13.0 years) were enrolled into final analysis (Fig 1). Their demographic characteristics were shown in Table 1.

Bottom Line: Asians are more susceptible to non-alcoholic steatohepatitis (NASH) as well as metabolic disorder than other ethnicities.Multivariate logistic regression analysis showed that a decreased serum albumin level (OR = 40.0, 95% CI = 4.5-300, P = 0.001) and normal uric acid level (OR = 5.6, 95% CI = 1.5-21.7, P = 0.01) were the significant factors associated with significant fibrosis.Females might carry a more disease severity than males in Taiwanese NASH patients.

View Article: PubMed Central - PubMed

Affiliation: Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

ABSTRACT

Background & aims: Asians are more susceptible to non-alcoholic steatohepatitis (NASH) as well as metabolic disorder than other ethnicities. We aimed to assess the interaction between metabolic factors and fibrosis in Taiwanese NASH patients.

Methods: A total of 130 biopsy-proven Taiwanese NASH patients (94 males, age = 43.0 ± 13.0 years) were consecutively enrolled. Their demographic, metabolic profiles and histopathological manifestations were analyzed.

Results: Twenty-four (18.5%) NASH patients were non-obese. Thirty-three (25.4%) patients had significant fibrosis (F2) or more: 22 (16.9%) patients were of F2, whilst 11 (8.5%) patients were of advanced fibrosis (F3-4). The prevalence of metabolic syndrome, diabetes and hypertension were 60.8%, 39.4%, and 61.5%, respectively. There was a significant inverse correlation between hyperuricemia and fibrosis stages, ranging from 48.4% of F0-1, 33.3% of F2, and 9.1% of F3-4, respectively (P = 0.01, linear trend). Multivariate logistic regression analysis showed that a decreased serum albumin level (OR = 40.0, 95% CI = 4.5-300, P = 0.001) and normal uric acid level (OR = 5.6, 95% CI = 1.5-21.7, P = 0.01) were the significant factors associated with significant fibrosis.

Conclusions: Hyperuricemia inversely predicts fibrosis stages. Females might carry a more disease severity than males in Taiwanese NASH patients.

No MeSH data available.


Related in: MedlinePlus