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Accuracy of QuantiFERON-TB Gold Test for Tuberculosis Diagnosis in Children.

Sali M, Buonsenso D, Goletti D, D'Alfonso P, Zumbo A, Fadda G, Sanguinetti M, Delogu G, Valentini P - PLoS ONE (2015)

Bottom Line: The overall specificity for active TB was 93.6%.Our results indicate that the children's response to QFT-IT associates to active TB and risk factors for LTBI.Moreover, we show that mitogen response is also found in children of 1 year of age, providing support for QFT-IT use also in young children.

View Article: PubMed Central - PubMed

Affiliation: Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy.

ABSTRACT

Objectives: To evaluate the accuracy of the QuantiFERON-TB Gold assay (QFT-IT) in children with suspected active or latent TB infection (LTBI).

Methods: A retrospective study was conducted on 621 children (0-14 years old) evaluated for TB infection or disease. Following clinical assessment, children were tested with the QFT-IT assay.

Results: Among the 140 active TB suspects, we identified 19 cases of active disease. The overall sensitivity for active TB was 87.5%, ranging from 62.5% in children 25-36 months old to 100% in children older than 49 months. The overall specificity for active TB was 93.6%. Among the 481 children tested for LTBI screening, 38 scored positive and all but 2 had at least one risk factor for TB infection. Among the 26 children with indeterminate results, bacterial, viral or fungal pneumonia were later diagnosed in 11 (42.3%) cases and non-TB related extra-pulmonary infections in 12 (46.1%).

Conclusions: Our results indicate that the children's response to QFT-IT associates to active TB and risk factors for LTBI. Moreover, we show that mitogen response is also found in children of 1 year of age, providing support for QFT-IT use also in young children.

No MeSH data available.


Related in: MedlinePlus

Flow chart of the study.(Abbreviations: TB: tuberculosis; LTBI: latent TB infection; QFT-IT: QUANTIferon TB Gold in tube.)
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pone.0138952.g001: Flow chart of the study.(Abbreviations: TB: tuberculosis; LTBI: latent TB infection; QFT-IT: QUANTIferon TB Gold in tube.)

Mentions: We evaluated 621 children, 275 (44.3%) were female; Fig 1 summarizes the children evaluated as patients with suspected active TB and children screened for LTBI. The mean age of the study population was 49 months (range 0 to 140 months) (Table 1). Regarding the origins, 180 children (28.9%) were Italian and 441 (71.0%) were foreigners, mostly born outside of Italy (394; 89.3%), and only 47 (10.6%) were born to foreign parents in Italy. All of the foreign children came from middle or high TB-burden countries (East Europe, Africa, South America, Asia) and most of them were internationally adopted children (352, 56.5% of the total study population).


Accuracy of QuantiFERON-TB Gold Test for Tuberculosis Diagnosis in Children.

Sali M, Buonsenso D, Goletti D, D'Alfonso P, Zumbo A, Fadda G, Sanguinetti M, Delogu G, Valentini P - PLoS ONE (2015)

Flow chart of the study.(Abbreviations: TB: tuberculosis; LTBI: latent TB infection; QFT-IT: QUANTIferon TB Gold in tube.)
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595419&req=5

pone.0138952.g001: Flow chart of the study.(Abbreviations: TB: tuberculosis; LTBI: latent TB infection; QFT-IT: QUANTIferon TB Gold in tube.)
Mentions: We evaluated 621 children, 275 (44.3%) were female; Fig 1 summarizes the children evaluated as patients with suspected active TB and children screened for LTBI. The mean age of the study population was 49 months (range 0 to 140 months) (Table 1). Regarding the origins, 180 children (28.9%) were Italian and 441 (71.0%) were foreigners, mostly born outside of Italy (394; 89.3%), and only 47 (10.6%) were born to foreign parents in Italy. All of the foreign children came from middle or high TB-burden countries (East Europe, Africa, South America, Asia) and most of them were internationally adopted children (352, 56.5% of the total study population).

Bottom Line: The overall specificity for active TB was 93.6%.Our results indicate that the children's response to QFT-IT associates to active TB and risk factors for LTBI.Moreover, we show that mitogen response is also found in children of 1 year of age, providing support for QFT-IT use also in young children.

View Article: PubMed Central - PubMed

Affiliation: Institute of Microbiology, Università Cattolica del Sacro Cuore, Rome, Italy.

ABSTRACT

Objectives: To evaluate the accuracy of the QuantiFERON-TB Gold assay (QFT-IT) in children with suspected active or latent TB infection (LTBI).

Methods: A retrospective study was conducted on 621 children (0-14 years old) evaluated for TB infection or disease. Following clinical assessment, children were tested with the QFT-IT assay.

Results: Among the 140 active TB suspects, we identified 19 cases of active disease. The overall sensitivity for active TB was 87.5%, ranging from 62.5% in children 25-36 months old to 100% in children older than 49 months. The overall specificity for active TB was 93.6%. Among the 481 children tested for LTBI screening, 38 scored positive and all but 2 had at least one risk factor for TB infection. Among the 26 children with indeterminate results, bacterial, viral or fungal pneumonia were later diagnosed in 11 (42.3%) cases and non-TB related extra-pulmonary infections in 12 (46.1%).

Conclusions: Our results indicate that the children's response to QFT-IT associates to active TB and risk factors for LTBI. Moreover, we show that mitogen response is also found in children of 1 year of age, providing support for QFT-IT use also in young children.

No MeSH data available.


Related in: MedlinePlus