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Circulating concentration of markers of angiogenic activity in patients with sarcoidosis and idiopathic pulmonary fibrosis.

Ziora D, Jastrzębski D, Adamek M, Czuba Z, Kozielski JJ, Grzanka A, Kasperska-Zajac A - BMC Pulm Med (2015)

Bottom Line: Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases.In contrast, Ang-2 and VEGF concentrations did not differ significantly between the three groups.These results indicate that differences may exist in angiogenic activity between patients with parenchymal lung diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Lung Diseases and Tuberculosis, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. zioradar@wp.pl.

ABSTRACT

Background: Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases. The aim of the study was to compare the angiogenic profile of patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF) based on analysis of circulating factors.

Methods: Serum concentrations of angiopoietin-2 (Ang-2), follistatin, granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin-8 (IL-8), platelet derived growth factor-BB (PDGF-BB), platelet endothelial cellular adhesion molecule-1 (PECAM-1) and vascular endothelial growth factors (VEGF) were measured in the patients and the healthy subjects.

Results: Serum concentrations of G-CSF, follistatin, PECAM-1 and IL-8 were significantly higher in the IPF patients in comparison with the control group and the sarcoid patients. PDGF-BB concentrations were also significantly higher in serum of IPF patients than in sarcoid patients, but not than in the controls. In contrast, Ang-2 and VEGF concentrations did not differ significantly between the three groups. In the sarcoid patients, irrespective of the disease activity or the radiological stage, serum concentrations of these cytokines were similar to the control group.

Conclusions: These results indicate that differences may exist in angiogenic activity between patients with parenchymal lung diseases. In contrast to sarcoidosis, IPF is characterized by a higher serum concentration of different molecules involved in the angiogenic processes .

No MeSH data available.


Related in: MedlinePlus

Individual serum concentrations of angiopoeitin-2 in patients with sarcoidosis and IPF in comparison to the control group. IPF vs sarcoidosis and vs control group, p > 0.05
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Fig1: Individual serum concentrations of angiopoeitin-2 in patients with sarcoidosis and IPF in comparison to the control group. IPF vs sarcoidosis and vs control group, p > 0.05

Mentions: In the IPF patients in comparison with the control group and the sarcoid patients we observed significantly higher serum concentrations of GM-CSF, follistatin, PECAM-1 and IL-8. Serum concentrations of PDGF-BB were also significantly higher in the IPF patients than in the sarcoid patients but not than in the controls. In the IPF patients, serum Ang-2 and VEGF concentrations did not differ significantly from these obtained in the sarcoid group and the controls (Table 2 and Figs. 1, 2, 3, 4, 5, 6, and 7). In the IPF group we found statistically significant correlations between concentrations of Ang-2 and IL-8 (r = 0.62, P < 0.01), follistatin and PECAM-1 (r = 0.83, P < 0.0001) and PDGF-BB and VEGF (r = 0.7, P < 0.01).Table 2


Circulating concentration of markers of angiogenic activity in patients with sarcoidosis and idiopathic pulmonary fibrosis.

Ziora D, Jastrzębski D, Adamek M, Czuba Z, Kozielski JJ, Grzanka A, Kasperska-Zajac A - BMC Pulm Med (2015)

Individual serum concentrations of angiopoeitin-2 in patients with sarcoidosis and IPF in comparison to the control group. IPF vs sarcoidosis and vs control group, p > 0.05
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4595322&req=5

Fig1: Individual serum concentrations of angiopoeitin-2 in patients with sarcoidosis and IPF in comparison to the control group. IPF vs sarcoidosis and vs control group, p > 0.05
Mentions: In the IPF patients in comparison with the control group and the sarcoid patients we observed significantly higher serum concentrations of GM-CSF, follistatin, PECAM-1 and IL-8. Serum concentrations of PDGF-BB were also significantly higher in the IPF patients than in the sarcoid patients but not than in the controls. In the IPF patients, serum Ang-2 and VEGF concentrations did not differ significantly from these obtained in the sarcoid group and the controls (Table 2 and Figs. 1, 2, 3, 4, 5, 6, and 7). In the IPF group we found statistically significant correlations between concentrations of Ang-2 and IL-8 (r = 0.62, P < 0.01), follistatin and PECAM-1 (r = 0.83, P < 0.0001) and PDGF-BB and VEGF (r = 0.7, P < 0.01).Table 2

Bottom Line: Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases.In contrast, Ang-2 and VEGF concentrations did not differ significantly between the three groups.These results indicate that differences may exist in angiogenic activity between patients with parenchymal lung diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Lung Diseases and Tuberculosis, SMDZ in Zabrze, Medical University of Silesia, Katowice, Poland. zioradar@wp.pl.

ABSTRACT

Background: Angiogenesis is an important process involved in the pathogenesis of diffuse parenchymal lung diseases. The aim of the study was to compare the angiogenic profile of patients with sarcoidosis and idiopathic pulmonary fibrosis (IPF) based on analysis of circulating factors.

Methods: Serum concentrations of angiopoietin-2 (Ang-2), follistatin, granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin-8 (IL-8), platelet derived growth factor-BB (PDGF-BB), platelet endothelial cellular adhesion molecule-1 (PECAM-1) and vascular endothelial growth factors (VEGF) were measured in the patients and the healthy subjects.

Results: Serum concentrations of G-CSF, follistatin, PECAM-1 and IL-8 were significantly higher in the IPF patients in comparison with the control group and the sarcoid patients. PDGF-BB concentrations were also significantly higher in serum of IPF patients than in sarcoid patients, but not than in the controls. In contrast, Ang-2 and VEGF concentrations did not differ significantly between the three groups. In the sarcoid patients, irrespective of the disease activity or the radiological stage, serum concentrations of these cytokines were similar to the control group.

Conclusions: These results indicate that differences may exist in angiogenic activity between patients with parenchymal lung diseases. In contrast to sarcoidosis, IPF is characterized by a higher serum concentration of different molecules involved in the angiogenic processes .

No MeSH data available.


Related in: MedlinePlus