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Structural and Functional Outcomes in Chronic Central Serous Chorioretinopathy Treated with Photodynamic Therapy.

Cidad P, González E, Asencio M, García J - Korean J Ophthalmol (2015)

Bottom Line: Time evolution and number of outbreaks were related to the decrease in foveal and chorodial thickness and in those with worse BCVA and CS.RPE abnormalities and atrophy were related to the age of onset of symptoms.Photoreceptor elongation has been correlated with poor BCVA and inner and outer segment line destructuring and interruption with poor CS.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Service, Hospital Universitario La Paz, Madrid, Spain.

ABSTRACT

Purpose: To study the retinal pigment epithelium (RPE) and retinal alterations in chronic central serous chorioretinopathy treated with photodynamic therapy, and its correlation with functional parameters such as best-corrected visual acuity (BCVA) and contrast sensitivity (CS).

Methods: Retrospective, noncomparative, consecutive evaluation by optical coherence tomography and its correlation with BCVA and CS in 31 eyes of 26 patients.

Results: In all affected patients, 88.5% were male with a mean age of 42.9 years. The right eye was involved in 64.5% of cases, bilateral in 19% and 73.9% were hyperopic (spherical refraction between 0 and +5.0 diopters). Of these cases, 51.5% had peri-RPE abnormalities, 17.3% hyperreflective substances at RPE, 19.4% RPE atrophy, 55.3% foveolar atrophy, 3.1% pigment epithelial detachment, 5.2% subretinal fluid persistence, 8.3% fibrin deposits, 68.4% photoreceptor inner and outer segment line interruption and 31.1% external limiting membrane interruption.

Conclusions: Time evolution and number of outbreaks were related to the decrease in foveal and chorodial thickness and in those with worse BCVA and CS. RPE abnormalities and atrophy were related to the age of onset of symptoms. Photoreceptor elongation has been correlated with poor BCVA and inner and outer segment line destructuring and interruption with poor CS.

No MeSH data available.


Related in: MedlinePlus

(A) Case A with hyper-reflective substances visualized by optical coherence tomography (OCT). (B) Case B shows anatomic success objectified by OCT. (C) Case C, OCT demonstrates foveolar atrophy. (D) Case D, pigment epithelial detachment and inner and outer segment line interruption. T = temporal; N = nasal.
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Figure 2: (A) Case A with hyper-reflective substances visualized by optical coherence tomography (OCT). (B) Case B shows anatomic success objectified by OCT. (C) Case C, OCT demonstrates foveolar atrophy. (D) Case D, pigment epithelial detachment and inner and outer segment line interruption. T = temporal; N = nasal.

Mentions: Retrospective, noncomparative consecutive study conducted in a tertiary center in Madrid, Spain. Patients with chronic CSC (at least 6 months or longer) treated with verteporfin PDT were included. Patients with media opacities or uncontrolled glaucoma, history of intraocular surgery or previous vitreoretinal disease were excluded. All patients underwent a complete ophthalmic examination including BCVA (logarithm of the minimum angle of resolution, logMAR), CS (Pelli Robson), biomicroscopy, funduscopy and OCT (software 512x128 macular cube and 5 HDline Cirrus raster; Carl Zeiss Meditec, Dublin, CA, USA) (Fig. 1). We considered individual epidemiological factors (sex, age, personality type, history of gastrointestinal disease, affected eye, refraction and previous systemic and ocular treatments), and the following variables collected by OCT: foveolar atrophy, subretinal fluid persistence, RPE integrity, peri-RPE abnormalities, pigment epithelium detachment (PED), hyperreflective substances, presence of fibrin deposits, photoreceptor inner and outer segment (IS/OS) line interruption, external limiting membrane abnormalities, and the presence of choroidal lakes and choroidal thickness (Table 1 and Fig. 2).


Structural and Functional Outcomes in Chronic Central Serous Chorioretinopathy Treated with Photodynamic Therapy.

Cidad P, González E, Asencio M, García J - Korean J Ophthalmol (2015)

(A) Case A with hyper-reflective substances visualized by optical coherence tomography (OCT). (B) Case B shows anatomic success objectified by OCT. (C) Case C, OCT demonstrates foveolar atrophy. (D) Case D, pigment epithelial detachment and inner and outer segment line interruption. T = temporal; N = nasal.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595259&req=5

Figure 2: (A) Case A with hyper-reflective substances visualized by optical coherence tomography (OCT). (B) Case B shows anatomic success objectified by OCT. (C) Case C, OCT demonstrates foveolar atrophy. (D) Case D, pigment epithelial detachment and inner and outer segment line interruption. T = temporal; N = nasal.
Mentions: Retrospective, noncomparative consecutive study conducted in a tertiary center in Madrid, Spain. Patients with chronic CSC (at least 6 months or longer) treated with verteporfin PDT were included. Patients with media opacities or uncontrolled glaucoma, history of intraocular surgery or previous vitreoretinal disease were excluded. All patients underwent a complete ophthalmic examination including BCVA (logarithm of the minimum angle of resolution, logMAR), CS (Pelli Robson), biomicroscopy, funduscopy and OCT (software 512x128 macular cube and 5 HDline Cirrus raster; Carl Zeiss Meditec, Dublin, CA, USA) (Fig. 1). We considered individual epidemiological factors (sex, age, personality type, history of gastrointestinal disease, affected eye, refraction and previous systemic and ocular treatments), and the following variables collected by OCT: foveolar atrophy, subretinal fluid persistence, RPE integrity, peri-RPE abnormalities, pigment epithelium detachment (PED), hyperreflective substances, presence of fibrin deposits, photoreceptor inner and outer segment (IS/OS) line interruption, external limiting membrane abnormalities, and the presence of choroidal lakes and choroidal thickness (Table 1 and Fig. 2).

Bottom Line: Time evolution and number of outbreaks were related to the decrease in foveal and chorodial thickness and in those with worse BCVA and CS.RPE abnormalities and atrophy were related to the age of onset of symptoms.Photoreceptor elongation has been correlated with poor BCVA and inner and outer segment line destructuring and interruption with poor CS.

View Article: PubMed Central - PubMed

Affiliation: Ophthalmology Service, Hospital Universitario La Paz, Madrid, Spain.

ABSTRACT

Purpose: To study the retinal pigment epithelium (RPE) and retinal alterations in chronic central serous chorioretinopathy treated with photodynamic therapy, and its correlation with functional parameters such as best-corrected visual acuity (BCVA) and contrast sensitivity (CS).

Methods: Retrospective, noncomparative, consecutive evaluation by optical coherence tomography and its correlation with BCVA and CS in 31 eyes of 26 patients.

Results: In all affected patients, 88.5% were male with a mean age of 42.9 years. The right eye was involved in 64.5% of cases, bilateral in 19% and 73.9% were hyperopic (spherical refraction between 0 and +5.0 diopters). Of these cases, 51.5% had peri-RPE abnormalities, 17.3% hyperreflective substances at RPE, 19.4% RPE atrophy, 55.3% foveolar atrophy, 3.1% pigment epithelial detachment, 5.2% subretinal fluid persistence, 8.3% fibrin deposits, 68.4% photoreceptor inner and outer segment line interruption and 31.1% external limiting membrane interruption.

Conclusions: Time evolution and number of outbreaks were related to the decrease in foveal and chorodial thickness and in those with worse BCVA and CS. RPE abnormalities and atrophy were related to the age of onset of symptoms. Photoreceptor elongation has been correlated with poor BCVA and inner and outer segment line destructuring and interruption with poor CS.

No MeSH data available.


Related in: MedlinePlus