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Clinical Outcomes of Eyes with Submacular Hemorrhage Secondary to Age-related Macular Degeneration Treated with Anti-vascular Endothelial Growth Factor.

Kim KH, Kim JH, Chang YS, Lee TG, Kim JW, Lew YJ - Korean J Ophthalmol (2015)

Bottom Line: Best-corrected visual acuity (BCVA) measurements obtained at diagnosis, six months, and the final visit were compared.Both baseline BCVA (p = 0.012) and BCVA at six months (p < 0.001) were significantly associated with BCVA at the final visit.BCVA at six months is a useful clinical index to predict long-term visual prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) monotherapy for patients diagnosed with submacular hemorrhage secondary to exudative age-related macular degeneration.

Methods: This retrospective, observational study included 49 patients (49 eyes) who initially presented with submacular hemorrhage associated with exudative age-related macular degeneration and who were followed-up for at least 24 months. Only eyes that were treated with intravitreal anti-VEGF monotherapy were included in the study. Best-corrected visual acuity (BCVA) measurements obtained at diagnosis, six months, and the final visit were compared. The associations of BCVA at the final visit with baseline BCVA, BCVA at six months, symptom duration, hemorrhage extent, and central foveal thickness were also analyzed.

Results: Over the course of follow-up (mean, 32.1 ± 8.5 months), an average of 5.1 ± 2.2 anti-VEGF injections were administered. Recurrent hemorrhage was noted in 13 eyes (26.5%). The mean logarithm of the minimal angle of resolution BCVA at diagnosis, six months, and the final visit were 1.40 ± 0.52, 0.87 ± 0.64, and 1.03 ± 0.83, respectively. Both baseline BCVA (p = 0.012) and BCVA at six months (p < 0.001) were significantly associated with BCVA at the final visit.

Conclusions: Improved visual acuity was maintained for more than two years with intravitreal anti-VEGF monotherapy. BCVA at six months is a useful clinical index to predict long-term visual prognosis.

No MeSH data available.


Related in: MedlinePlus

Fundus photography and optical coherence tomography findings of an eye with submacular hemorrhage secondary to polypoidal choroidal vasculopathy. At the time of diagnosis, visual acuity was measured as 20 / 100 (A,B). At 6 months, the hemorrhage had resolved completely, and visual acuity had improved to 20 / 25 (C,D). The eye was treated with 5 ranibizumab injections during the 28-month follow-up period. At 28 months, visual acuity was maintained at 20 / 25 (E,F).
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Figure 1: Fundus photography and optical coherence tomography findings of an eye with submacular hemorrhage secondary to polypoidal choroidal vasculopathy. At the time of diagnosis, visual acuity was measured as 20 / 100 (A,B). At 6 months, the hemorrhage had resolved completely, and visual acuity had improved to 20 / 25 (C,D). The eye was treated with 5 ranibizumab injections during the 28-month follow-up period. At 28 months, visual acuity was maintained at 20 / 25 (E,F).

Mentions: Fig. 1 shows a representative case of long-term change in the macular microstructure of an eye with submacular hemorrhage. The mean BCVA values at baseline, six months post-diagnosis, 12 months post-diagnosis, and at the final visit were 1.40 ± 0.52 (Snellen equivalent, 20 / 502), 0.87 ± 0.64 (Snellen equivalent, 20 / 148), 0.88 ± 0.68 (Snellen equivalent, 20 / 151), and 1.03 ± 0.83 (Snellen equivalent, 20 / 214), respectively (Fig. 2A). BCVA values differed significantly among the four time points (p < 0.001). The mean BCVA at the final visit showed significant improvement compared to the baseline value (p = 0.012), whereas the differences between the BCVA values at six months and at 12 months were not significantly different from BCVA at the final visit (p = 0.156 and p = 0.113, respectively). Compared to baseline values, a BCVA improvement of three lines or more was noted in 28 eyes (57.1%) at the final visit. A deterioration of three or more lines was noted in nine eyes (18.4%). The remaining 12 eyes (24.5%) exhibited stable BCVA throughout the follow-up period.


Clinical Outcomes of Eyes with Submacular Hemorrhage Secondary to Age-related Macular Degeneration Treated with Anti-vascular Endothelial Growth Factor.

Kim KH, Kim JH, Chang YS, Lee TG, Kim JW, Lew YJ - Korean J Ophthalmol (2015)

Fundus photography and optical coherence tomography findings of an eye with submacular hemorrhage secondary to polypoidal choroidal vasculopathy. At the time of diagnosis, visual acuity was measured as 20 / 100 (A,B). At 6 months, the hemorrhage had resolved completely, and visual acuity had improved to 20 / 25 (C,D). The eye was treated with 5 ranibizumab injections during the 28-month follow-up period. At 28 months, visual acuity was maintained at 20 / 25 (E,F).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595257&req=5

Figure 1: Fundus photography and optical coherence tomography findings of an eye with submacular hemorrhage secondary to polypoidal choroidal vasculopathy. At the time of diagnosis, visual acuity was measured as 20 / 100 (A,B). At 6 months, the hemorrhage had resolved completely, and visual acuity had improved to 20 / 25 (C,D). The eye was treated with 5 ranibizumab injections during the 28-month follow-up period. At 28 months, visual acuity was maintained at 20 / 25 (E,F).
Mentions: Fig. 1 shows a representative case of long-term change in the macular microstructure of an eye with submacular hemorrhage. The mean BCVA values at baseline, six months post-diagnosis, 12 months post-diagnosis, and at the final visit were 1.40 ± 0.52 (Snellen equivalent, 20 / 502), 0.87 ± 0.64 (Snellen equivalent, 20 / 148), 0.88 ± 0.68 (Snellen equivalent, 20 / 151), and 1.03 ± 0.83 (Snellen equivalent, 20 / 214), respectively (Fig. 2A). BCVA values differed significantly among the four time points (p < 0.001). The mean BCVA at the final visit showed significant improvement compared to the baseline value (p = 0.012), whereas the differences between the BCVA values at six months and at 12 months were not significantly different from BCVA at the final visit (p = 0.156 and p = 0.113, respectively). Compared to baseline values, a BCVA improvement of three lines or more was noted in 28 eyes (57.1%) at the final visit. A deterioration of three or more lines was noted in nine eyes (18.4%). The remaining 12 eyes (24.5%) exhibited stable BCVA throughout the follow-up period.

Bottom Line: Best-corrected visual acuity (BCVA) measurements obtained at diagnosis, six months, and the final visit were compared.Both baseline BCVA (p = 0.012) and BCVA at six months (p < 0.001) were significantly associated with BCVA at the final visit.BCVA at six months is a useful clinical index to predict long-term visual prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.

ABSTRACT

Purpose: To evaluate the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) monotherapy for patients diagnosed with submacular hemorrhage secondary to exudative age-related macular degeneration.

Methods: This retrospective, observational study included 49 patients (49 eyes) who initially presented with submacular hemorrhage associated with exudative age-related macular degeneration and who were followed-up for at least 24 months. Only eyes that were treated with intravitreal anti-VEGF monotherapy were included in the study. Best-corrected visual acuity (BCVA) measurements obtained at diagnosis, six months, and the final visit were compared. The associations of BCVA at the final visit with baseline BCVA, BCVA at six months, symptom duration, hemorrhage extent, and central foveal thickness were also analyzed.

Results: Over the course of follow-up (mean, 32.1 ± 8.5 months), an average of 5.1 ± 2.2 anti-VEGF injections were administered. Recurrent hemorrhage was noted in 13 eyes (26.5%). The mean logarithm of the minimal angle of resolution BCVA at diagnosis, six months, and the final visit were 1.40 ± 0.52, 0.87 ± 0.64, and 1.03 ± 0.83, respectively. Both baseline BCVA (p = 0.012) and BCVA at six months (p < 0.001) were significantly associated with BCVA at the final visit.

Conclusions: Improved visual acuity was maintained for more than two years with intravitreal anti-VEGF monotherapy. BCVA at six months is a useful clinical index to predict long-term visual prognosis.

No MeSH data available.


Related in: MedlinePlus