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Choroidal Blood Flow Change in Eyes with High Myopia.

Yang YS, Koh JW - Korean J Ophthalmol (2015)

Bottom Line: High myopes showed significantly lower OBFa, OBFv, and POBF than the other groups (all p < 0.001).These finding explains the influence of axial length on OBFa, OBFv, and POBF, but not on OBFr.Thus, changes in axial length and the possible influence of these changes on the physical properties of choroidal vessels is the mechanism believed to be responsible for putting high myopes at risk for ocular vascular diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Chosun University School of Medicine, Gwangju, Korea.

ABSTRACT

Purpose: To evaluate choroidal blood flow changes in eyes with high myopia according to the pulsatile components of ocular blood flow analysis.

Methods: A total of 104 subjects (52 males and 52 females) were included in this study. One eye of each participant was randomly selected and assigned to one of four refractive groups, designated as, hyperopes (n = 20; refractive error, ≥+1.00 diopter [D]), emmetropes (n = 28; refractive error, ±0.75 D), lower myopes (n = 33; refractive error, -1.00 to -4.75 D), and high myopes (n = 23; refractive error, ≤-5.00 D). Components of pulse amplitude (OBFa), pulse volume (OBFv), pulse rate (OBFr), and pulsatile ocular blood flow (POBF) were analyzed using a blood flow analyzer. Intraocular pressure and axial length were measured.

Results: Pulsatile components of OBFa, OBFv, and POBF showed positive correlations with refractive error and showed negative correlations with axial length (r = 0.729, r = 0.772, r = 0.781, respectively, all p < 0.001; r = -0.727, r = -0.762, r = -0.771, respectively, all p < 0.001). The correlations of refractive error and axial length with OBFr were irrelevant (r = -0.157, p = 0.113; r = 0.123, p = 0.213). High myopes showed significantly lower OBFa, OBFv, and POBF than the other groups (all p < 0.001).

Conclusions: Axial length changes in high myopes potentially influence choroidal blood flow, assuming the changes are caused by narrowing of the choroidal vessel diameter and increasing rigidity of the choroidal vessel wall. These finding explains the influence of axial length on OBFa, OBFv, and POBF, but not on OBFr. Thus, changes in axial length and the possible influence of these changes on the physical properties of choroidal vessels is the mechanism believed to be responsible for putting high myopes at risk for ocular vascular diseases.

No MeSH data available.


Related in: MedlinePlus

Mean value, 95% confidence interval, and range of pulsatile ocular blood flow (POBF) in different groups.
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Figure 1: Mean value, 95% confidence interval, and range of pulsatile ocular blood flow (POBF) in different groups.

Mentions: Data for 104 subjects (52 males and 52 females) were included in the analysis (mean age, 25.68 ± 2.12 years; range, 22 to 29 years). All subjects had a best-corrected visual acuity of better than 20 / 20. The mean IOP was 14.65 ± 1.79 mmHg (range, 10 to 20 mmHg), and the mean POBF value was 1,182.46 ± 192.51 µL/min (range, 804 to 1,632 µL/min). Only one eye of each subject was randomly included and assigned to one of four refractive groups. Fig. 1 shows the mean values and the ranges of POBF in the different groups. Fig. 2 shows the relationship between refractive error and axial length (r = -0.972, p < 0.001).


Choroidal Blood Flow Change in Eyes with High Myopia.

Yang YS, Koh JW - Korean J Ophthalmol (2015)

Mean value, 95% confidence interval, and range of pulsatile ocular blood flow (POBF) in different groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595256&req=5

Figure 1: Mean value, 95% confidence interval, and range of pulsatile ocular blood flow (POBF) in different groups.
Mentions: Data for 104 subjects (52 males and 52 females) were included in the analysis (mean age, 25.68 ± 2.12 years; range, 22 to 29 years). All subjects had a best-corrected visual acuity of better than 20 / 20. The mean IOP was 14.65 ± 1.79 mmHg (range, 10 to 20 mmHg), and the mean POBF value was 1,182.46 ± 192.51 µL/min (range, 804 to 1,632 µL/min). Only one eye of each subject was randomly included and assigned to one of four refractive groups. Fig. 1 shows the mean values and the ranges of POBF in the different groups. Fig. 2 shows the relationship between refractive error and axial length (r = -0.972, p < 0.001).

Bottom Line: High myopes showed significantly lower OBFa, OBFv, and POBF than the other groups (all p < 0.001).These finding explains the influence of axial length on OBFa, OBFv, and POBF, but not on OBFr.Thus, changes in axial length and the possible influence of these changes on the physical properties of choroidal vessels is the mechanism believed to be responsible for putting high myopes at risk for ocular vascular diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Chosun University School of Medicine, Gwangju, Korea.

ABSTRACT

Purpose: To evaluate choroidal blood flow changes in eyes with high myopia according to the pulsatile components of ocular blood flow analysis.

Methods: A total of 104 subjects (52 males and 52 females) were included in this study. One eye of each participant was randomly selected and assigned to one of four refractive groups, designated as, hyperopes (n = 20; refractive error, ≥+1.00 diopter [D]), emmetropes (n = 28; refractive error, ±0.75 D), lower myopes (n = 33; refractive error, -1.00 to -4.75 D), and high myopes (n = 23; refractive error, ≤-5.00 D). Components of pulse amplitude (OBFa), pulse volume (OBFv), pulse rate (OBFr), and pulsatile ocular blood flow (POBF) were analyzed using a blood flow analyzer. Intraocular pressure and axial length were measured.

Results: Pulsatile components of OBFa, OBFv, and POBF showed positive correlations with refractive error and showed negative correlations with axial length (r = 0.729, r = 0.772, r = 0.781, respectively, all p < 0.001; r = -0.727, r = -0.762, r = -0.771, respectively, all p < 0.001). The correlations of refractive error and axial length with OBFr were irrelevant (r = -0.157, p = 0.113; r = 0.123, p = 0.213). High myopes showed significantly lower OBFa, OBFv, and POBF than the other groups (all p < 0.001).

Conclusions: Axial length changes in high myopes potentially influence choroidal blood flow, assuming the changes are caused by narrowing of the choroidal vessel diameter and increasing rigidity of the choroidal vessel wall. These finding explains the influence of axial length on OBFa, OBFv, and POBF, but not on OBFr. Thus, changes in axial length and the possible influence of these changes on the physical properties of choroidal vessels is the mechanism believed to be responsible for putting high myopes at risk for ocular vascular diseases.

No MeSH data available.


Related in: MedlinePlus