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Frontoparietal Structural Connectivity Mediates the Top-Down Control of Neuronal Synchronization Associated with Selective Attention.

Marshall TR, Bergmann TO, Jensen O - PLoS Biol. (2015)

Bottom Line: We then quantified the modulations in oscillatory activity using magnetoencephalography in the same subjects performing a spatial attention task.We found that subjects with a stronger SLF volume in the right compared to the left hemisphere (or vice versa) also were the subjects who had a better ability to modulate right compared to left hemisphere alpha and gamma band synchronization, with the latter also predicting biases in reaction time.Our findings implicate the medial branch of the SLF in mediating top-down control of neuronal synchronization in sensory regions that support selective attention.

View Article: PubMed Central - PubMed

Affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.

ABSTRACT
Neuronal synchronization reflected by oscillatory brain activity has been strongly implicated in the mechanisms supporting selective gating. We here aimed at identifying the anatomical pathways in humans supporting the top-down control of neuronal synchronization. We first collected diffusion imaging data using magnetic resonance imaging to identify the medial branch of the superior longitudinal fasciculus (SLF), a white-matter tract connecting frontal control areas to parietal regions. We then quantified the modulations in oscillatory activity using magnetoencephalography in the same subjects performing a spatial attention task. We found that subjects with a stronger SLF volume in the right compared to the left hemisphere (or vice versa) also were the subjects who had a better ability to modulate right compared to left hemisphere alpha and gamma band synchronization, with the latter also predicting biases in reaction time. Our findings implicate the medial branch of the SLF in mediating top-down control of neuronal synchronization in sensory regions that support selective attention.

No MeSH data available.


(A) Correlation of gamma modulation asymmetry in the middle occipital cortex (see Fig 2) with volumetric asymmetry of the three SLF branches. The gamma modulation asymmetry was calculated by comparing the degree of attentional modulation (left versus right spatial cue) in the right versus the left hemisphere. In the case of the SLF1, gamma modulation asymmetry was strongly positively correlated with volumetric hemispheric asymmetry (p = 0.0016, significant at the p < 0.005 level after Bonferroni correction for three comparisons). Neither SLF2 nor SLF3 showed such a correlation. (B) The same correlations but for alpha modulation asymmetry in superior occipital cortex (see Fig 2). Only SLF1 volumetric hemispheric asymmetry showed a significant negative correlation with alpha modulation asymmetry (p = 0.0096, significant at the p < 0.05 level after Bonferroni correction for three comparisons). As such, subjects with stronger left than right tracks in SLF1 were able to modulate the left compared to right hemisphere alpha and gamma power to a larger degree.
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pbio.1002272.g004: (A) Correlation of gamma modulation asymmetry in the middle occipital cortex (see Fig 2) with volumetric asymmetry of the three SLF branches. The gamma modulation asymmetry was calculated by comparing the degree of attentional modulation (left versus right spatial cue) in the right versus the left hemisphere. In the case of the SLF1, gamma modulation asymmetry was strongly positively correlated with volumetric hemispheric asymmetry (p = 0.0016, significant at the p < 0.005 level after Bonferroni correction for three comparisons). Neither SLF2 nor SLF3 showed such a correlation. (B) The same correlations but for alpha modulation asymmetry in superior occipital cortex (see Fig 2). Only SLF1 volumetric hemispheric asymmetry showed a significant negative correlation with alpha modulation asymmetry (p = 0.0096, significant at the p < 0.05 level after Bonferroni correction for three comparisons). As such, subjects with stronger left than right tracks in SLF1 were able to modulate the left compared to right hemisphere alpha and gamma power to a larger degree.

Mentions: Our main finding (Fig 4A, top panel) shows that gamma modulation asymmetry was strongly positively correlated with SLF1 hemispheric asymmetry (r = 0.596, r2 = 0.36, p = 0.0016, Spearman, significant at the p < 0.005 level after Bonferroni correction for three comparisons). This demonstrates that subjects who displayed relatively greater gamma modulation in the left hemisphere than in the right hemisphere also had relatively greater tract volume in the left than in the right hemisphere (and vice versa). No correlation was observed with SLF2 or SLF3 (in all cases p > 0.05 without Bonferroni correction).


Frontoparietal Structural Connectivity Mediates the Top-Down Control of Neuronal Synchronization Associated with Selective Attention.

Marshall TR, Bergmann TO, Jensen O - PLoS Biol. (2015)

(A) Correlation of gamma modulation asymmetry in the middle occipital cortex (see Fig 2) with volumetric asymmetry of the three SLF branches. The gamma modulation asymmetry was calculated by comparing the degree of attentional modulation (left versus right spatial cue) in the right versus the left hemisphere. In the case of the SLF1, gamma modulation asymmetry was strongly positively correlated with volumetric hemispheric asymmetry (p = 0.0016, significant at the p < 0.005 level after Bonferroni correction for three comparisons). Neither SLF2 nor SLF3 showed such a correlation. (B) The same correlations but for alpha modulation asymmetry in superior occipital cortex (see Fig 2). Only SLF1 volumetric hemispheric asymmetry showed a significant negative correlation with alpha modulation asymmetry (p = 0.0096, significant at the p < 0.05 level after Bonferroni correction for three comparisons). As such, subjects with stronger left than right tracks in SLF1 were able to modulate the left compared to right hemisphere alpha and gamma power to a larger degree.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4595220&req=5

pbio.1002272.g004: (A) Correlation of gamma modulation asymmetry in the middle occipital cortex (see Fig 2) with volumetric asymmetry of the three SLF branches. The gamma modulation asymmetry was calculated by comparing the degree of attentional modulation (left versus right spatial cue) in the right versus the left hemisphere. In the case of the SLF1, gamma modulation asymmetry was strongly positively correlated with volumetric hemispheric asymmetry (p = 0.0016, significant at the p < 0.005 level after Bonferroni correction for three comparisons). Neither SLF2 nor SLF3 showed such a correlation. (B) The same correlations but for alpha modulation asymmetry in superior occipital cortex (see Fig 2). Only SLF1 volumetric hemispheric asymmetry showed a significant negative correlation with alpha modulation asymmetry (p = 0.0096, significant at the p < 0.05 level after Bonferroni correction for three comparisons). As such, subjects with stronger left than right tracks in SLF1 were able to modulate the left compared to right hemisphere alpha and gamma power to a larger degree.
Mentions: Our main finding (Fig 4A, top panel) shows that gamma modulation asymmetry was strongly positively correlated with SLF1 hemispheric asymmetry (r = 0.596, r2 = 0.36, p = 0.0016, Spearman, significant at the p < 0.005 level after Bonferroni correction for three comparisons). This demonstrates that subjects who displayed relatively greater gamma modulation in the left hemisphere than in the right hemisphere also had relatively greater tract volume in the left than in the right hemisphere (and vice versa). No correlation was observed with SLF2 or SLF3 (in all cases p > 0.05 without Bonferroni correction).

Bottom Line: We then quantified the modulations in oscillatory activity using magnetoencephalography in the same subjects performing a spatial attention task.We found that subjects with a stronger SLF volume in the right compared to the left hemisphere (or vice versa) also were the subjects who had a better ability to modulate right compared to left hemisphere alpha and gamma band synchronization, with the latter also predicting biases in reaction time.Our findings implicate the medial branch of the SLF in mediating top-down control of neuronal synchronization in sensory regions that support selective attention.

View Article: PubMed Central - PubMed

Affiliation: Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.

ABSTRACT
Neuronal synchronization reflected by oscillatory brain activity has been strongly implicated in the mechanisms supporting selective gating. We here aimed at identifying the anatomical pathways in humans supporting the top-down control of neuronal synchronization. We first collected diffusion imaging data using magnetic resonance imaging to identify the medial branch of the superior longitudinal fasciculus (SLF), a white-matter tract connecting frontal control areas to parietal regions. We then quantified the modulations in oscillatory activity using magnetoencephalography in the same subjects performing a spatial attention task. We found that subjects with a stronger SLF volume in the right compared to the left hemisphere (or vice versa) also were the subjects who had a better ability to modulate right compared to left hemisphere alpha and gamma band synchronization, with the latter also predicting biases in reaction time. Our findings implicate the medial branch of the SLF in mediating top-down control of neuronal synchronization in sensory regions that support selective attention.

No MeSH data available.