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Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies.

Tang W, Cui D, Jiang L, Zhao L, Qian W, Long SA, Xu K - J. Cell. Mol. Med. (2015)

Bottom Line: However, the results from individual studies are inconsistent.Similar results were obtained when all the included studies were calculated by a REM.This conclusion warrants confirmation by further studies.

View Article: PubMed Central - PubMed

Affiliation: The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China.

No MeSH data available.


Related in: MedlinePlus

Flow chart of meta-analysis for selecting published studies on the association of IL2RA polymorphism and T1D risk.
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fig01: Flow chart of meta-analysis for selecting published studies on the association of IL2RA polymorphism and T1D risk.

Mentions: A total of 10 studies 5,9,13–17,19,20 with 19 outcomes met the inclusion and exclusion criteria (Fig. 1). All were case-control studies and most were population-based. Of these, eight studies involved Europeans, two were of Asians. The genotype frequency in controls was in HWE for all included studies. Some studies only provided ORs with 95% CIs under the minor allelic comparison, hence the summary estimate was calculated with this model. Their characteristics are listed (Table 1). The association of rs11594656, rs2104286, rs3118470, rs41295061 and rs706778 polymorphisms with T1D was examined in 5, 3, 3, 5 and 3 studies respectively.


Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies.

Tang W, Cui D, Jiang L, Zhao L, Qian W, Long SA, Xu K - J. Cell. Mol. Med. (2015)

Flow chart of meta-analysis for selecting published studies on the association of IL2RA polymorphism and T1D risk.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4594689&req=5

fig01: Flow chart of meta-analysis for selecting published studies on the association of IL2RA polymorphism and T1D risk.
Mentions: A total of 10 studies 5,9,13–17,19,20 with 19 outcomes met the inclusion and exclusion criteria (Fig. 1). All were case-control studies and most were population-based. Of these, eight studies involved Europeans, two were of Asians. The genotype frequency in controls was in HWE for all included studies. Some studies only provided ORs with 95% CIs under the minor allelic comparison, hence the summary estimate was calculated with this model. Their characteristics are listed (Table 1). The association of rs11594656, rs2104286, rs3118470, rs41295061 and rs706778 polymorphisms with T1D was examined in 5, 3, 3, 5 and 3 studies respectively.

Bottom Line: However, the results from individual studies are inconsistent.Similar results were obtained when all the included studies were calculated by a REM.This conclusion warrants confirmation by further studies.

View Article: PubMed Central - PubMed

Affiliation: The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China.

No MeSH data available.


Related in: MedlinePlus