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Effects of Eccentric and Concentric Emphasized Resistance Exercise on IL-15 Serum Levels and Its Relation to Inflammatory Markers in Athletes and Non-Athletes.

Bazgir B, Salesi M, Koushki M, Amirghofran Z - Asian J Sports Med (2015)

Bottom Line: For athletes, the hs-CRP levels significantly decreased (P < 0.05).The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

View Article: PubMed Central - PubMed

Affiliation: Exercise Physiology Research Center (EPRC), Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Cytokines play an important role in modulating the muscle's metabolic and immunological responses to exercise.

Objectives: In the present study, we investigated changes in the serum levels of Interleukin (IL)-15 as well as tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hs-CRP), as markers of inflammation, in athlete and non-athlete young men following eccentric (ECC) and concentric (CON) emphasized resistance exercise (RE).

Patients and methods: This study recruited 28 young males, 14 athletes and 14 non-athletes. Subjects completed two bouts of ECC and CON emphasized RE five days apart. Each bout included seven exercises that emphasized all major muscle groups with weight loads of 70% - 80% of one repetition maximum (1RM) for CON RE and 90% - 100% of 1RM for ECC RE. We analyzed subjects' blood samples before and immediately after each bout of exercise to determine cytokine and hs-CRP serum levels according to enzyme-linked immunosorbent assay.

Results: Statistical analysis showed a significant difference between IL-15 serum levels before and after ECC and CON RE in non-athletes (P = 0.03). In athletes, IL-15 serum level only increased after ECC RE (P = 0.01), which was noted to be the highest degree of change in IL-15 levels in all subjects. For athletes, the hs-CRP levels significantly decreased (P < 0.05). The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.

Conclusions: These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

No MeSH data available.


Related in: MedlinePlus

White Blood Cell (WBC) Change After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant differences before and after RE (P < 0.05).
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fig22706: White Blood Cell (WBC) Change After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant differences before and after RE (P < 0.05).

Mentions: As shown in Figure 3, the level of hs-CRP before and after ECC RE in athletes changed from 1.68 ± 2 to 0.92 ± 1.4 µg/mL (P = 0.01). ECC RE in non-athletes also significantly reduced the level of hs-CRP (0.99 ± 0.7 to 0.45 ± 0.5 µg/mL, P = 0.008, Figure 3A). Although the mean serum level of hs-CRP in both groups decreased after CON RE, it was not significant (Figure 3B). No significant correlation between changes in the level of hs-CRP and the cytokines was found. The number of WBCs as an index of systemic inflammation significantly increased after both RE protocols (Figures 4A and B, P < 0.05).


Effects of Eccentric and Concentric Emphasized Resistance Exercise on IL-15 Serum Levels and Its Relation to Inflammatory Markers in Athletes and Non-Athletes.

Bazgir B, Salesi M, Koushki M, Amirghofran Z - Asian J Sports Med (2015)

White Blood Cell (WBC) Change After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant differences before and after RE (P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4594145&req=5

fig22706: White Blood Cell (WBC) Change After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant differences before and after RE (P < 0.05).
Mentions: As shown in Figure 3, the level of hs-CRP before and after ECC RE in athletes changed from 1.68 ± 2 to 0.92 ± 1.4 µg/mL (P = 0.01). ECC RE in non-athletes also significantly reduced the level of hs-CRP (0.99 ± 0.7 to 0.45 ± 0.5 µg/mL, P = 0.008, Figure 3A). Although the mean serum level of hs-CRP in both groups decreased after CON RE, it was not significant (Figure 3B). No significant correlation between changes in the level of hs-CRP and the cytokines was found. The number of WBCs as an index of systemic inflammation significantly increased after both RE protocols (Figures 4A and B, P < 0.05).

Bottom Line: For athletes, the hs-CRP levels significantly decreased (P < 0.05).The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

View Article: PubMed Central - PubMed

Affiliation: Exercise Physiology Research Center (EPRC), Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Cytokines play an important role in modulating the muscle's metabolic and immunological responses to exercise.

Objectives: In the present study, we investigated changes in the serum levels of Interleukin (IL)-15 as well as tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hs-CRP), as markers of inflammation, in athlete and non-athlete young men following eccentric (ECC) and concentric (CON) emphasized resistance exercise (RE).

Patients and methods: This study recruited 28 young males, 14 athletes and 14 non-athletes. Subjects completed two bouts of ECC and CON emphasized RE five days apart. Each bout included seven exercises that emphasized all major muscle groups with weight loads of 70% - 80% of one repetition maximum (1RM) for CON RE and 90% - 100% of 1RM for ECC RE. We analyzed subjects' blood samples before and immediately after each bout of exercise to determine cytokine and hs-CRP serum levels according to enzyme-linked immunosorbent assay.

Results: Statistical analysis showed a significant difference between IL-15 serum levels before and after ECC and CON RE in non-athletes (P = 0.03). In athletes, IL-15 serum level only increased after ECC RE (P = 0.01), which was noted to be the highest degree of change in IL-15 levels in all subjects. For athletes, the hs-CRP levels significantly decreased (P < 0.05). The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.

Conclusions: These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

No MeSH data available.


Related in: MedlinePlus