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Effects of Eccentric and Concentric Emphasized Resistance Exercise on IL-15 Serum Levels and Its Relation to Inflammatory Markers in Athletes and Non-Athletes.

Bazgir B, Salesi M, Koushki M, Amirghofran Z - Asian J Sports Med (2015)

Bottom Line: For athletes, the hs-CRP levels significantly decreased (P < 0.05).The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

View Article: PubMed Central - PubMed

Affiliation: Exercise Physiology Research Center (EPRC), Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Cytokines play an important role in modulating the muscle's metabolic and immunological responses to exercise.

Objectives: In the present study, we investigated changes in the serum levels of Interleukin (IL)-15 as well as tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hs-CRP), as markers of inflammation, in athlete and non-athlete young men following eccentric (ECC) and concentric (CON) emphasized resistance exercise (RE).

Patients and methods: This study recruited 28 young males, 14 athletes and 14 non-athletes. Subjects completed two bouts of ECC and CON emphasized RE five days apart. Each bout included seven exercises that emphasized all major muscle groups with weight loads of 70% - 80% of one repetition maximum (1RM) for CON RE and 90% - 100% of 1RM for ECC RE. We analyzed subjects' blood samples before and immediately after each bout of exercise to determine cytokine and hs-CRP serum levels according to enzyme-linked immunosorbent assay.

Results: Statistical analysis showed a significant difference between IL-15 serum levels before and after ECC and CON RE in non-athletes (P = 0.03). In athletes, IL-15 serum level only increased after ECC RE (P = 0.01), which was noted to be the highest degree of change in IL-15 levels in all subjects. For athletes, the hs-CRP levels significantly decreased (P < 0.05). The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.

Conclusions: These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

No MeSH data available.


Related in: MedlinePlus

IL-15 Serum Level Changes After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant difference between the level of IL-15 before and after RE (P < 0.05).
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fig22703: IL-15 Serum Level Changes After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant difference between the level of IL-15 before and after RE (P < 0.05).

Mentions: IL-15 serum levels significantly increased after ECC emphasized RE in both groups. The level of this cytokine changed from 1.43 ± 0.17 to 1.62 ± 0.28 pg/mL (P = 0.002) in non-athletes (Figure 1A) and from 1.72 ± 0.4 to 2.46 ± 1.3 pg/mL (P = 0.01) in athletes after ECC RE (Figure 1B). With respect to CON emphasized RE, there was only a significant up-regulation of IL-15 in non-athletes. The level of IL-15 after CON RE in this group changed from 1.79 ± 0.6 to 2.16 ± 0.6 (P = 0.03, Figure 1A). Comparison of the serum IL-15 levels in athlete and non-athlete groups after each RE showed the highest IL-15 increase in athletes after ECC RE (0.73 ± 0.97 pg/mL).


Effects of Eccentric and Concentric Emphasized Resistance Exercise on IL-15 Serum Levels and Its Relation to Inflammatory Markers in Athletes and Non-Athletes.

Bazgir B, Salesi M, Koushki M, Amirghofran Z - Asian J Sports Med (2015)

IL-15 Serum Level Changes After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant difference between the level of IL-15 before and after RE (P < 0.05).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4594145&req=5

fig22703: IL-15 Serum Level Changes After Concentric (CON) and Eccentric (ECC) Resistance Exercise (RE) in Non-Athlete (A) and Athlete Group (B)Asterisks show significant difference between the level of IL-15 before and after RE (P < 0.05).
Mentions: IL-15 serum levels significantly increased after ECC emphasized RE in both groups. The level of this cytokine changed from 1.43 ± 0.17 to 1.62 ± 0.28 pg/mL (P = 0.002) in non-athletes (Figure 1A) and from 1.72 ± 0.4 to 2.46 ± 1.3 pg/mL (P = 0.01) in athletes after ECC RE (Figure 1B). With respect to CON emphasized RE, there was only a significant up-regulation of IL-15 in non-athletes. The level of IL-15 after CON RE in this group changed from 1.79 ± 0.6 to 2.16 ± 0.6 (P = 0.03, Figure 1A). Comparison of the serum IL-15 levels in athlete and non-athlete groups after each RE showed the highest IL-15 increase in athletes after ECC RE (0.73 ± 0.97 pg/mL).

Bottom Line: For athletes, the hs-CRP levels significantly decreased (P < 0.05).The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

View Article: PubMed Central - PubMed

Affiliation: Exercise Physiology Research Center (EPRC), Baqiyatallah University of Medical Sciences, Tehran, IR Iran.

ABSTRACT

Background: Cytokines play an important role in modulating the muscle's metabolic and immunological responses to exercise.

Objectives: In the present study, we investigated changes in the serum levels of Interleukin (IL)-15 as well as tumor necrosis factor (TNF)-α and high sensitivity C-reactive protein (hs-CRP), as markers of inflammation, in athlete and non-athlete young men following eccentric (ECC) and concentric (CON) emphasized resistance exercise (RE).

Patients and methods: This study recruited 28 young males, 14 athletes and 14 non-athletes. Subjects completed two bouts of ECC and CON emphasized RE five days apart. Each bout included seven exercises that emphasized all major muscle groups with weight loads of 70% - 80% of one repetition maximum (1RM) for CON RE and 90% - 100% of 1RM for ECC RE. We analyzed subjects' blood samples before and immediately after each bout of exercise to determine cytokine and hs-CRP serum levels according to enzyme-linked immunosorbent assay.

Results: Statistical analysis showed a significant difference between IL-15 serum levels before and after ECC and CON RE in non-athletes (P = 0.03). In athletes, IL-15 serum level only increased after ECC RE (P = 0.01), which was noted to be the highest degree of change in IL-15 levels in all subjects. For athletes, the hs-CRP levels significantly decreased (P < 0.05). The serum levels of both TNF-α and hs-CRP were also significantly down-regulated after ECC RE in non-athletes.

Conclusions: These results indicated that fitness level and RE could modulate circulating levels of IL-15 and suggest the potential anti-inflammatory effects of IL-15 during RE.

No MeSH data available.


Related in: MedlinePlus