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Synthesis, characterization, and cytotoxicity in human erythrocytes of multifunctional, magnetic, and luminescent nanocrystalline rare earth fluorides.

Grzyb T, Mrówczyńska L, Szczeszak A, Śniadecki Z, Runowski M, Idzikowski B, Lis S - J Nanopart Res (2015)

Bottom Line: The highest luminescence was observed for BaGdF5-based materials.The particles' magnetic characteristics were also preserved for samples in the form of a suspension in distilled water.The cytotoxicity studies against the human erythrocytes indicated that the synthesized nanoparticles are non-toxic because they did not cause the red blood cells shape changes nor did they alter their membrane structure and permeabilization.

View Article: PubMed Central - PubMed

Affiliation: Department of Rare Earths, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznan, Poland.

ABSTRACT

Multifunctional nanoparticles exhibiting red or green luminescence properties and magnetism were synthesized and thoroughly analyzed. The hydrothermal method was used for the synthesis of Eu(3+)- or Tb(3+)-doped GdF3-, NaGdF4-, and BaGdF5-based nanocrystalline materials. The X-ray diffraction patterns of the samples confirmed the desired compositions of the materials. Transmission electron microscope images revealed the different morphologies of the products, including the nanocrystal sizes, which varied from 12 nm in the case of BaGdF5-based nanoparticles to larger structures with dimensions exceeding 300 nm. All of the samples presented luminescence under ultraviolet irradiation, as well as when the samples were in the form of water colloids. The highest luminescence was observed for BaGdF5-based materials. The obtained nanoparticles exhibited paramagnetism along with probable evidence of superparamagnetic behavior at low temperatures. The particles' magnetic characteristics were also preserved for samples in the form of a suspension in distilled water. The cytotoxicity studies against the human erythrocytes indicated that the synthesized nanoparticles are non-toxic because they did not cause the red blood cells shape changes nor did they alter their membrane structure and permeabilization.

No MeSH data available.


Related in: MedlinePlus

The sedimentation rate of RBSs in the presence of nanoparticles after 1 h at 37 °C. (a) 5 mg/mL, (b) 1 mg/mL, (c) 0.5 mg/mL, and (d) 0.05 mg/mL. (1) PBS (control), (2) NaGdF4:2.5 %Ce3+,2.5 %Eu3+, (3) NaGdF4:2.5 %Ce3+,2.5 %Tb3+, (4) GdF3:2.5 %Ce3+,2.5 %Eu3+, (5) GdF3:2.5 %Ce3+,2.5 %Tb3+, (6) GdF3:2.5 %Ce3+,2.5 %Eu3+ (NaBF4), (7) GdF3:2.5 %Ce3+,2.5 %Tb3+ (NaBF4), (8) BaGdF5:2.5 %Ce3+,2.5 %Eu3+, and (9) BaGdF5:2.5 %Ce3+, 2.5 %Tb3+
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Fig8: The sedimentation rate of RBSs in the presence of nanoparticles after 1 h at 37 °C. (a) 5 mg/mL, (b) 1 mg/mL, (c) 0.5 mg/mL, and (d) 0.05 mg/mL. (1) PBS (control), (2) NaGdF4:2.5 %Ce3+,2.5 %Eu3+, (3) NaGdF4:2.5 %Ce3+,2.5 %Tb3+, (4) GdF3:2.5 %Ce3+,2.5 %Eu3+, (5) GdF3:2.5 %Ce3+,2.5 %Tb3+, (6) GdF3:2.5 %Ce3+,2.5 %Eu3+ (NaBF4), (7) GdF3:2.5 %Ce3+,2.5 %Tb3+ (NaBF4), (8) BaGdF5:2.5 %Ce3+,2.5 %Eu3+, and (9) BaGdF5:2.5 %Ce3+, 2.5 %Tb3+

Mentions: The RBCs settled at the same sedimentation rate as the control erythrocytes are at 0.5 and 0.05 mg/mL nanoparticle concentrations (Fig. 8c–d). At the higher concentrations, namely, 1 mg/mL and 5 mg/mL, slight disturbances of the RBC sedimentation were observed (Fig. 8a, b). According to present data, the sedimentation disturbance could be induced by two factors: the colloidal nature of the nanoparticle solutions or by the nanoparticles, especially their aggregates, attached to the RBC membrane. Although the first factor seems to be more probable, the synergic action of both could not be excluded.Fig. 8


Synthesis, characterization, and cytotoxicity in human erythrocytes of multifunctional, magnetic, and luminescent nanocrystalline rare earth fluorides.

Grzyb T, Mrówczyńska L, Szczeszak A, Śniadecki Z, Runowski M, Idzikowski B, Lis S - J Nanopart Res (2015)

The sedimentation rate of RBSs in the presence of nanoparticles after 1 h at 37 °C. (a) 5 mg/mL, (b) 1 mg/mL, (c) 0.5 mg/mL, and (d) 0.05 mg/mL. (1) PBS (control), (2) NaGdF4:2.5 %Ce3+,2.5 %Eu3+, (3) NaGdF4:2.5 %Ce3+,2.5 %Tb3+, (4) GdF3:2.5 %Ce3+,2.5 %Eu3+, (5) GdF3:2.5 %Ce3+,2.5 %Tb3+, (6) GdF3:2.5 %Ce3+,2.5 %Eu3+ (NaBF4), (7) GdF3:2.5 %Ce3+,2.5 %Tb3+ (NaBF4), (8) BaGdF5:2.5 %Ce3+,2.5 %Eu3+, and (9) BaGdF5:2.5 %Ce3+, 2.5 %Tb3+
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

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Fig8: The sedimentation rate of RBSs in the presence of nanoparticles after 1 h at 37 °C. (a) 5 mg/mL, (b) 1 mg/mL, (c) 0.5 mg/mL, and (d) 0.05 mg/mL. (1) PBS (control), (2) NaGdF4:2.5 %Ce3+,2.5 %Eu3+, (3) NaGdF4:2.5 %Ce3+,2.5 %Tb3+, (4) GdF3:2.5 %Ce3+,2.5 %Eu3+, (5) GdF3:2.5 %Ce3+,2.5 %Tb3+, (6) GdF3:2.5 %Ce3+,2.5 %Eu3+ (NaBF4), (7) GdF3:2.5 %Ce3+,2.5 %Tb3+ (NaBF4), (8) BaGdF5:2.5 %Ce3+,2.5 %Eu3+, and (9) BaGdF5:2.5 %Ce3+, 2.5 %Tb3+
Mentions: The RBCs settled at the same sedimentation rate as the control erythrocytes are at 0.5 and 0.05 mg/mL nanoparticle concentrations (Fig. 8c–d). At the higher concentrations, namely, 1 mg/mL and 5 mg/mL, slight disturbances of the RBC sedimentation were observed (Fig. 8a, b). According to present data, the sedimentation disturbance could be induced by two factors: the colloidal nature of the nanoparticle solutions or by the nanoparticles, especially their aggregates, attached to the RBC membrane. Although the first factor seems to be more probable, the synergic action of both could not be excluded.Fig. 8

Bottom Line: The highest luminescence was observed for BaGdF5-based materials.The particles' magnetic characteristics were also preserved for samples in the form of a suspension in distilled water.The cytotoxicity studies against the human erythrocytes indicated that the synthesized nanoparticles are non-toxic because they did not cause the red blood cells shape changes nor did they alter their membrane structure and permeabilization.

View Article: PubMed Central - PubMed

Affiliation: Department of Rare Earths, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznan, Poland.

ABSTRACT

Multifunctional nanoparticles exhibiting red or green luminescence properties and magnetism were synthesized and thoroughly analyzed. The hydrothermal method was used for the synthesis of Eu(3+)- or Tb(3+)-doped GdF3-, NaGdF4-, and BaGdF5-based nanocrystalline materials. The X-ray diffraction patterns of the samples confirmed the desired compositions of the materials. Transmission electron microscope images revealed the different morphologies of the products, including the nanocrystal sizes, which varied from 12 nm in the case of BaGdF5-based nanoparticles to larger structures with dimensions exceeding 300 nm. All of the samples presented luminescence under ultraviolet irradiation, as well as when the samples were in the form of water colloids. The highest luminescence was observed for BaGdF5-based materials. The obtained nanoparticles exhibited paramagnetism along with probable evidence of superparamagnetic behavior at low temperatures. The particles' magnetic characteristics were also preserved for samples in the form of a suspension in distilled water. The cytotoxicity studies against the human erythrocytes indicated that the synthesized nanoparticles are non-toxic because they did not cause the red blood cells shape changes nor did they alter their membrane structure and permeabilization.

No MeSH data available.


Related in: MedlinePlus