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The clinical manifestations and treatment of male breast cancer: a report of three cases

View Article: PubMed Central

ABSTRACT

Male breast cancer is an extremely rare malignancy. We treated three male breast cancer patients. All three patients showed clinical N0 and received sentinel lymph node biopsy. Because the sentinel lymph node was positive for metastasis in one patient, a total mastectomy with axillary lymph node dissection was performed. The other two patients were negative for sentinel lymph node metastasis, and a simple mastectomy was performed. Two of the patients were postoperatively treated with tamoxifen; another patient was treated with adjuvant chemotherapy using taxotere and cyclophosphamide before tamoxifen. There was no recurrence in any of the three patients during an average follow-up period of 56.7 months (range 11.8–80.3). A sentinel lymph node biopsy is recommended for node staging in both male and female breast cancer patients as it is associated with a lower incidence of complications.

No MeSH data available.


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a A preoperative US scan showing a round mass of 24 mm in diameter in the right subareolar area. b A preoperative chest CT scan showing a round tumor of 24 mm in diameter in the right subareolar area
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Fig3: a A preoperative US scan showing a round mass of 24 mm in diameter in the right subareolar area. b A preoperative chest CT scan showing a round tumor of 24 mm in diameter in the right subareolar area

Mentions: A 69-year-old man presented to his family doctor complaining of a tumor in his right breast that he noticed a few days before his presentation. A US scan showed a well-defined round tumor of 25 mm in diameter under the nipple (Fig. 3a). A core needle biopsy suggested invasive ductal carcinoma. A CT scan showed a tumor of 24 mm in diameter under the nipple without axillary lymph node swelling or distant metastasis (Fig. 3b). He was referred to our hospital for surgery. The clinical diagnosis was cT2N0M0, stage IIA. On the day before operation, sentinel lymphoscintigraphy was performed. SLNB was performed by the radioisotope and dye method. A pathological examination of the three removed SLNs was conducted pathological during surgery, which showed metastasis in one SLN. After SLNB, a total mastectomy of the left breast was performed with level II axillary lymph node dissection. The tumor was diagnosed as an invasive ductal carcinoma (histological grade 3, ER-positive, PR-positive HER2 score 0, Ki67 index 21 %). A pathological examination showed metastasis in 2 of 15 axillary lymph nodes. The final diagnosis was pT2N1M0, stage IIB. Adjuvant chemotherapy, consisting of taxotere (75 mg/m2, 120 mg/body), and cyclophosphamide (600 mg/m2, 1000 mg/body) was administered in four courses following the standard treatment guidelines for FBC. Adjuvant chemotherapy without anthracycline was administered because of the patient’s hypertension. After chemotherapy, he was treated with tamoxifen (20 mg) due to the ER and PgR positivity of the tumor. The patient experienced axillary paresthesia, a decreased range of motion of the shoulder and arm, but has experienced no recurrence in the 10 months since surgery.Fig. 3


The clinical manifestations and treatment of male breast cancer: a report of three cases
a A preoperative US scan showing a round mass of 24 mm in diameter in the right subareolar area. b A preoperative chest CT scan showing a round tumor of 24 mm in diameter in the right subareolar area
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4593990&req=5

Fig3: a A preoperative US scan showing a round mass of 24 mm in diameter in the right subareolar area. b A preoperative chest CT scan showing a round tumor of 24 mm in diameter in the right subareolar area
Mentions: A 69-year-old man presented to his family doctor complaining of a tumor in his right breast that he noticed a few days before his presentation. A US scan showed a well-defined round tumor of 25 mm in diameter under the nipple (Fig. 3a). A core needle biopsy suggested invasive ductal carcinoma. A CT scan showed a tumor of 24 mm in diameter under the nipple without axillary lymph node swelling or distant metastasis (Fig. 3b). He was referred to our hospital for surgery. The clinical diagnosis was cT2N0M0, stage IIA. On the day before operation, sentinel lymphoscintigraphy was performed. SLNB was performed by the radioisotope and dye method. A pathological examination of the three removed SLNs was conducted pathological during surgery, which showed metastasis in one SLN. After SLNB, a total mastectomy of the left breast was performed with level II axillary lymph node dissection. The tumor was diagnosed as an invasive ductal carcinoma (histological grade 3, ER-positive, PR-positive HER2 score 0, Ki67 index 21 %). A pathological examination showed metastasis in 2 of 15 axillary lymph nodes. The final diagnosis was pT2N1M0, stage IIB. Adjuvant chemotherapy, consisting of taxotere (75 mg/m2, 120 mg/body), and cyclophosphamide (600 mg/m2, 1000 mg/body) was administered in four courses following the standard treatment guidelines for FBC. Adjuvant chemotherapy without anthracycline was administered because of the patient’s hypertension. After chemotherapy, he was treated with tamoxifen (20 mg) due to the ER and PgR positivity of the tumor. The patient experienced axillary paresthesia, a decreased range of motion of the shoulder and arm, but has experienced no recurrence in the 10 months since surgery.Fig. 3

View Article: PubMed Central

ABSTRACT

Male breast cancer is an extremely rare malignancy. We treated three male breast cancer patients. All three patients showed clinical N0 and received sentinel lymph node biopsy. Because the sentinel lymph node was positive for metastasis in one patient, a total mastectomy with axillary lymph node dissection was performed. The other two patients were negative for sentinel lymph node metastasis, and a simple mastectomy was performed. Two of the patients were postoperatively treated with tamoxifen; another patient was treated with adjuvant chemotherapy using taxotere and cyclophosphamide before tamoxifen. There was no recurrence in any of the three patients during an average follow-up period of 56.7 months (range 11.8–80.3). A sentinel lymph node biopsy is recommended for node staging in both male and female breast cancer patients as it is associated with a lower incidence of complications.

No MeSH data available.


Related in: MedlinePlus