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The clinical manifestations and treatment of male breast cancer: a report of three cases

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ABSTRACT

Male breast cancer is an extremely rare malignancy. We treated three male breast cancer patients. All three patients showed clinical N0 and received sentinel lymph node biopsy. Because the sentinel lymph node was positive for metastasis in one patient, a total mastectomy with axillary lymph node dissection was performed. The other two patients were negative for sentinel lymph node metastasis, and a simple mastectomy was performed. Two of the patients were postoperatively treated with tamoxifen; another patient was treated with adjuvant chemotherapy using taxotere and cyclophosphamide before tamoxifen. There was no recurrence in any of the three patients during an average follow-up period of 56.7 months (range 11.8–80.3). A sentinel lymph node biopsy is recommended for node staging in both male and female breast cancer patients as it is associated with a lower incidence of complications.

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a A preoperative US scan showing a round mass of 16 mm in diameter in the left subareolar area. b A preoperative chest CT scan showing a round tumor of 16 mm in diameter in the left subareolar area
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Fig2: a A preoperative US scan showing a round mass of 16 mm in diameter in the left subareolar area. b A preoperative chest CT scan showing a round tumor of 16 mm in diameter in the left subareolar area

Mentions: A 64-year-old man visited to our hospital complaining of a tumor in his left breast that had been present for at least 3 months. A US scan showed a well-defined round tumor measuring 16 mm in diameter under the nipple (Fig. 2a). A cytological analysis of a fine needle aspiration biopsy specimen suggested malignancy. A CT scan showed a round tumor of 16 mm in diameter under the nipple without axillary lymph node swelling or distant metastasis (Fig. 2b). MMG were not performed. The clinical diagnosis was cT1cN0M0, stage I. On the day before the operation, sentinel lymphoscintigraphy was performed. Under general anesthesia, SLNB was performed by the radioisotope and dye method. The pathological diagnosis of the resected SLNs was conducted during surgery. No metastasis was found in the intraoperative examination of frozen sections of the two SLNs. After the SLNB, a total mastectomy of the left breast was performed. The tumor was diagnosed as an invasive ductal carcinoma (histological grade 1, ER-positive, PR-positive, HER2 0, Ki67 index 22.3 %). The pathological examination of the SLNs showed no signs of metastasis. The final diagnosis was pT1cN0M0, stage I. Because of the ER and PgR positivity of the tumor, the patient was treated with tamoxifen (20 mg) for 5 years. The patient did not suffer any complications and remains alive without any recurrent disease at 78 months after surgery.Fig. 2


The clinical manifestations and treatment of male breast cancer: a report of three cases
a A preoperative US scan showing a round mass of 16 mm in diameter in the left subareolar area. b A preoperative chest CT scan showing a round tumor of 16 mm in diameter in the left subareolar area
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4593990&req=5

Fig2: a A preoperative US scan showing a round mass of 16 mm in diameter in the left subareolar area. b A preoperative chest CT scan showing a round tumor of 16 mm in diameter in the left subareolar area
Mentions: A 64-year-old man visited to our hospital complaining of a tumor in his left breast that had been present for at least 3 months. A US scan showed a well-defined round tumor measuring 16 mm in diameter under the nipple (Fig. 2a). A cytological analysis of a fine needle aspiration biopsy specimen suggested malignancy. A CT scan showed a round tumor of 16 mm in diameter under the nipple without axillary lymph node swelling or distant metastasis (Fig. 2b). MMG were not performed. The clinical diagnosis was cT1cN0M0, stage I. On the day before the operation, sentinel lymphoscintigraphy was performed. Under general anesthesia, SLNB was performed by the radioisotope and dye method. The pathological diagnosis of the resected SLNs was conducted during surgery. No metastasis was found in the intraoperative examination of frozen sections of the two SLNs. After the SLNB, a total mastectomy of the left breast was performed. The tumor was diagnosed as an invasive ductal carcinoma (histological grade 1, ER-positive, PR-positive, HER2 0, Ki67 index 22.3 %). The pathological examination of the SLNs showed no signs of metastasis. The final diagnosis was pT1cN0M0, stage I. Because of the ER and PgR positivity of the tumor, the patient was treated with tamoxifen (20 mg) for 5 years. The patient did not suffer any complications and remains alive without any recurrent disease at 78 months after surgery.Fig. 2

View Article: PubMed Central

ABSTRACT

Male breast cancer is an extremely rare malignancy. We treated three male breast cancer patients. All three patients showed clinical N0 and received sentinel lymph node biopsy. Because the sentinel lymph node was positive for metastasis in one patient, a total mastectomy with axillary lymph node dissection was performed. The other two patients were negative for sentinel lymph node metastasis, and a simple mastectomy was performed. Two of the patients were postoperatively treated with tamoxifen; another patient was treated with adjuvant chemotherapy using taxotere and cyclophosphamide before tamoxifen. There was no recurrence in any of the three patients during an average follow-up period of 56.7 months (range 11.8–80.3). A sentinel lymph node biopsy is recommended for node staging in both male and female breast cancer patients as it is associated with a lower incidence of complications.

No MeSH data available.


Related in: MedlinePlus