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Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014.

Lindblade KA, Kateh F, Nagbe TK, Neatherlin JC, Pillai SK, Attfield KR, Dweh E, Barradas DT, Williams SG, Blackley DJ, Kirking HL, Patel MR, Dea M, Massoudi MS, Wannemuehler K, Barskey AE, Zarecki SL, Fomba M, Grube S, Belcher L, Broyles LN, Maxwell TN, Hagan JE, Yeoman K, Westercamp M, Forrester J, Mott J, Mahoney F, Slutsker L, DeCock KM, Nyenswah T - Emerging Infect. Dis. (2015)

Bottom Line: The reproduction number declined 94% from 1.7 (95% CI 1.1-2.6) to 0.1 (95% CI 0.02-0.6) after interventions began.The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04-0.3) than for those who died in the community.The case-fatality rate was 68% (95% CI 60-74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4-0.8).

View Article: PubMed Central - PubMed

ABSTRACT
We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1-2.6) to 0.1 (95% CI 0.02-0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04-0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60-74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4-0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.

No MeSH data available.


Related in: MedlinePlus

Communities in remote rural areas where Ebola virus disease outbreaks occurred, Liberia, August–December 2014. Size of red dot indicates number of cases.
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Figure 1: Communities in remote rural areas where Ebola virus disease outbreaks occurred, Liberia, August–December 2014. Size of red dot indicates number of cases.

Mentions: Fifteen outbreaks of Ebola occurred in remote areas of Liberia during July–December 2014 (6); 9 had transmission chains linking most cases to a source-patient and are included in this report (Figure 1; Table 1). The time when MOHSW was notified of an outbreak to the first day of public health intervention in the community was a median of 32 days (range 9–58 days) (Technical Appendix Figures 1, 2).


Decreased Ebola Transmission after Rapid Response to Outbreaks in Remote Areas, Liberia, 2014.

Lindblade KA, Kateh F, Nagbe TK, Neatherlin JC, Pillai SK, Attfield KR, Dweh E, Barradas DT, Williams SG, Blackley DJ, Kirking HL, Patel MR, Dea M, Massoudi MS, Wannemuehler K, Barskey AE, Zarecki SL, Fomba M, Grube S, Belcher L, Broyles LN, Maxwell TN, Hagan JE, Yeoman K, Westercamp M, Forrester J, Mott J, Mahoney F, Slutsker L, DeCock KM, Nyenswah T - Emerging Infect. Dis. (2015)

Communities in remote rural areas where Ebola virus disease outbreaks occurred, Liberia, August–December 2014. Size of red dot indicates number of cases.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4593457&req=5

Figure 1: Communities in remote rural areas where Ebola virus disease outbreaks occurred, Liberia, August–December 2014. Size of red dot indicates number of cases.
Mentions: Fifteen outbreaks of Ebola occurred in remote areas of Liberia during July–December 2014 (6); 9 had transmission chains linking most cases to a source-patient and are included in this report (Figure 1; Table 1). The time when MOHSW was notified of an outbreak to the first day of public health intervention in the community was a median of 32 days (range 9–58 days) (Technical Appendix Figures 1, 2).

Bottom Line: The reproduction number declined 94% from 1.7 (95% CI 1.1-2.6) to 0.1 (95% CI 0.02-0.6) after interventions began.The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04-0.3) than for those who died in the community.The case-fatality rate was 68% (95% CI 60-74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4-0.8).

View Article: PubMed Central - PubMed

ABSTRACT
We measured the reproduction number before and after interventions were implemented to reduce Ebola transmission in 9 outbreaks in Liberia during 2014. We evaluated risk factors for secondary cases and the association between patient admission to an Ebola treatment unit (ETU) and survival. The reproduction number declined 94% from 1.7 (95% CI 1.1-2.6) to 0.1 (95% CI 0.02-0.6) after interventions began. The risk for secondary infections was 90% lower for patients admitted to an ETU (risk ratio 0.1, 95% CI 0.04-0.3) than for those who died in the community. The case-fatality rate was 68% (95% CI 60-74), and ETU admission was associated with a 50% reduction in death (hazard ratio 0.5, 95% CI 0.4-0.8). Isolation and treatment of Ebola patients had the dual benefit of interrupting community transmission and improving survival.

No MeSH data available.


Related in: MedlinePlus